Microvascular Coronary Artery Disease, STEMI
Conditions
Brief summary
The investigators enrolled 217 patients with acute STEMI undergoing primary PCI. The rs2305619 polymorphism was evaluated by real time PCR and plasma PTX3 concentration was assessed by human PTX3 ELISA kit.
Detailed description
The investigators enrolled 217 patients with acute STEMI undergoing primary PCI in a tertiary care academic cardiovascular center. The rs2305619 polymorphism was evaluated by real time PCR and plasma PTX3 concentration was assessed by human PTX3 ELISA kit. The primary outcome of the study was the incidence of coronary microvascular obstruction defined as thrombolysis in myocardial infarction (TIMI) grade \<3 flow after primary PCI or TIMI grade 3 flow with myocardial blush grade 0 or 1. Patients were grouped based on the genotypic variants (AA, AG and GG). The primary outcome was compared among the three variants, as well as the PTX3 concentration and 30-day mortality.
Interventions
OTHERLong pentraxin 3
Primary PCI
Sponsors
Indonesian Cardiovascular Research Center
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with acute STEMI with symptom onset \<12 h and treated by primary PCI
Exclusion criteria
* STEMI patients who received fibrinolytic therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of microvascular obstruction | Immediate after pci | Percentage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of mortality | 30 days | Percentage |
Countries
Indonesia
Outcome results
None listed