Diabetes, Ovarian Failure
Conditions
Keywords
Antral follicle count, Anti müllerian hormone, Ovarian reserve, HbA1c, type 1 diabetes mellitus
Brief summary
The human ovary is the target of an autoimmune attack, usually in organ or non-specific autoimmune disorders. Serum anti-Müllerian hormone (AMH) levels decrease early in menopause and menopause is seen in women with type 1 diabetes mellitus (DM1) at a young age. DM1 is aimed to show DM1 relationship with ovarian reserve based on the assumption that it will have lower AMH levels than controls, secondary to bad glycemic control and autoimmune attack in women.
Detailed description
The study was designed prospectively. Ovarian functions in healthy volunteer women and patients who use DM1 diagnosed between 18-40 years old will be examined. Gonadotropin and AMH levels will be measured in follicular phase. To calculate the number of antral follicles (AFC) and ovarian volume, ultrasound will be looked at. Fasting and satiety blood glucose, HbA1c and C-peptide levels will be evaluated.
Interventions
DIAGNOSTIC_TESTovarian reserve
To assess ovarian reserve in patients with Type 1 Diabetes Mellitus aged 18-40 years; ultrasonographic and laboratory parameters will be looked at.
Sponsors
Kanuni Sultan Suleyman Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* female patients between 18 and 40 years of age who had consent and had gynecological examination in our polyclinic; * study group for patients with type 1 diabetes mellitus healthy volunteers control group
Exclusion criteria
* Other endocrine and / or autoimmune disorders, polycystic ovary syndrome (PCOS) and * previous surgery, which may reduce ovarian reserves; * medical and / or radiotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Antral follicle count (AFC) | On the 3rd day of the menstrual cycle | AFC was calculated by counting 2-10 mm diameter follicles in both ovaries with a standard systematic approach.Recorded as a number. |
| Anti müllerian hormone (AMH) | On the 3rd day of the menstrual cycle | AMH concentrations were measured by an enzymatically enhanced bilaterally immunoassay. AMH (pmol / l) saved as. |
| HbA1c | On the 3rd day of the menstrual cycle | HBA1C concentrations were measured by taking venous blood samples in the early morning hours. HBA1C (mmol / mol) saved as. |
Countries
Turkey (Türkiye)
Outcome results
None listed