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Plant-based Dietary Protein and Resistance-training Adaptations

Does Exclusive Consumption of Plant-based Dietary Protein Impair Resistance Training-induced Muscle Adaptations?

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03907059
Enrollment
38
Registered
2019-04-08
Start date
2017-03-31
Completion date
2018-10-19
Last updated
2019-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

protein source, hypertrophy, resistance training, plant-based protein, omnivorous

Brief summary

Dietary protein consumption maximizes the anabolic response during resistance training (RT) by triggering muscle protein synthesis and providing the indispensable amino acids for a net positive protein balance. Leucine is considered the key amino acid in this process, suggesting that differences in protein quality may influence RT-induced gains in muscle mass and strength. In general, plant-based protein sources have lower leucine concentrations than animal-based protein sources and human skeletal muscle. In this respect, despite acute evidence on lower anabolic properties of plant- vs. animal-based protein, the effects of an exclusive plant-based dietary protein diet on RT-induced adaptations are currently unknown.

Interventions

DIETARY_SUPPLEMENTwhey protein

supplementation individually adjusted to 1.6g/kg/day

DIETARY_SUPPLEMENTsoy protein

supplementation individually adjusted to 1.6g/kg/day

Sponsors

University of Sao Paulo
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy young men * Vegans ≥ 1 y or omnivorous subjects * Physically active but no resistance-trained subjects * Without any chronic injury that impairs resistance training performance * Protein intake \> 0.8 g/protein/kg body weight

Exclusion criteria

* Use of creatine or beta-alanine supplements for the last 3 months * Use of proteins and/or amino acids supplements for the last 1 month * Engagement in specific dietary restrictions * Previous use of anabolic steroids * Engagement in any training program

Design outcomes

Primary

MeasureTime frameDescription
Muscle cross-sectional area12 weeksassessed by mode-B ultrasound
Muscle strength12 weeksassessed by leg-press one-maximum-repetition

Secondary

MeasureTime frameDescription
Leg lean mass12 weeksassessed by Dual-energy X-ray absorptiometry
fiber cross-sectional area12 weeksassessed by muscle biopsy (vastus lateralis)

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 24, 2026