Diabetes Complications, Diabetes Mellitus, Type 1, Ischemia, Retinal Ischemia
Conditions
Brief summary
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury. It remains unknown whether this can be used in retinal ischemic diseases. The purpose of the present study is to examine if the autoregulation of retinal vessel diameters in diabetic patients change after remote ischemic conditioning and if the observations are different from what have been observed in normal persons.
Interventions
OTHERRemote Ischemic Conditioning
Brief reversible restriction of blood flow to upper limb in four cycles of 5 minutes of inflation at 200mm Hg followed by 5 minutes of deflation.
Sponsors
University of Aarhus
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 31 Years
Healthy volunteers
No
Inclusion criteria
* Diabetes type 1 * Diabetic retinopathy
Exclusion criteria
* Previous treatment for diabetic retinopathy * Other ocular and systemic diseases requiring treatment * Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diameter change of retinal vessels | Immediately after and one hour after | Diameter change from baseline in percent. |
Countries
Denmark
Outcome results
None listed