Diabetic Cardiomyopathy, Simultaneous Pancreas-kidney Transplantation
Conditions
Keywords
SPK ,DCM,CMR
Brief summary
Diabetic cardiomyopathy( DCM) is a major complication of diabetes and is a common cardiovascular complication independent of coronary artery disease and hypertension．Trial to assess of myocardial injury in recipients of simultaneous pancreas and kidney transplantation by nuclear magnetic T２ mapping technology.
Detailed description
1. Evaluate the changes of myocardial injury before and after SPK by cardiac magnetic resonance imaging (CMR), 2. Evaluate the value of SPK in the repair of myocardial injury by comparing with the single renal transplant in recipients with diabetic nephropathy.
Interventions
RADIATIONcardiac magnetic resonance(CMR) T2 mapping
T2 value before transplant，3 month and 6month after transplant
Sponsors
Tianjin First Central Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. patients with type 2 diabetes were treated with SPK; 2.No definite history of cardiovascular diseases (such as congenital heart disease, coronary heart disease, cardiomyopathy or valvular heart disease, etc.); 3. Preoperative hemodialysis 4. No history of heart failure
Exclusion criteria
1. Contraindications in cardiac magnetic resonance imaging；2.poorly controlled hypertension；3.CMR examination revealed marked hypertrophy of the left ventricular myocardium
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of myocardial injury | 1year | Assessment of myocardial injury between two groups |
Countries
China
Outcome results
None listed