Fibroid Uterus, IVF
Conditions
Brief summary
Women with intramural myoma not reaching the endometrial cavity will be randomized to either open myomectomy or no intervention . The participants will be assessed through full history-taking with special consideration to age and the duration, type, and cause of infertility. The medical examination included general, abdominal, and vaginal examinations. Finally, an ultrasonography examination was performed to check for the presence of three or more preantral follicles and to exclude ovarian cysts. On day 3 of a natural cycle, a baseline levels of FSH, luteinizing hormone (LH), , estradiol and anti-Müllerian hormone (AMH).Ovarian stimulation was performed using a long, antagonist, or short protocol. They were assigned to one of the 2 groups according to having an intramural myoma not indenting the cavity or not. All will be followed up by transvaginal ultrasonography . When two or more follicles had reached a mean diameter of 18 mm, oocyte maturation was triggered by intramuscular administration of hCG. Embryo transfer will be done at day 2, 3 or 5 according to the circumstances.
Detailed description
Women with intramural myoma not reaching the endometrial cavity will be randomized to either open myomectomy or no intervention .The participants will be assessed through full history-taking with special consideration to age and the duration, type, and cause of infertility. The medical examination included general, abdominal, and vaginal examinations. Finally, an ultrasonography examination was performed to check for the presence of three or more preantral follicles and to exclude ovarian cysts. On day 3 of a natural cycle, a baseline levels of FSH, luteinizing hormone (LH), , estradiol and anti-Müllerian hormone (AMH).Ovarian stimulation was performed using a long, antagonist, or short protocol. They were assigned to one of the 2 groups according to having an intramural myoma not indenting the cavity or not. All will be followed up by transvaginal ultrasonography . When two or more follicles had reached a mean diameter of 18 mm, oocyte maturation was triggered by intramuscular administration of hCG. Embryo transfer will be done at day 2, 3 or 5 according to the circumstances.
Interventions
PROCEDUREOpen myomectomy
laparotomy then enucleation of the myoma followed by closure of the myometrial cavity
DRUGGonadotropins
Gonadotropin stimulation of follicular growth
DRUGHuman chorionic gonadotropin
HCG triggering of ovulation
PROCEDUREOvum pick up
34 to 36 hours after HCG triggering
PROCEDUREEmbryo transfer
Transfer of 2 grade 1 embryo on day 2,3 or 5 from oocyte retrieval
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* • age younger than 40 years * FSH) less than 10 IU/L * serum prolactin level normal * uterine cavity abnormality was excluded by hysteroscopy or hysterosalpingography
Exclusion criteria
* abnormal endocrine function (e.g. abnormal thyroid or adrenal function) * ovarian cysts, * hydrosalpinx * endometrial polyps * male partner with azoospermia * ICSI performed for preimplantation genetic diagnosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy rate | 4 weeks after embryo transfer | appearance of one or more intrauterine gestational sac by transvaginal ultrasound |
Countries
Egypt
Contacts
Primary ContactAhmed Maged, MD
Outcome results
None listed