Exercise
Conditions
Brief summary
This study will compare short-term post-exercise muscle glycogen synthesis following combined galactose-glucose, glucose alone or galactose alone ingestion.
Detailed description
Lactose, the sugar contained within milk, consists of glucose and galactose. Post-exercise consumption of a carbohydrate mixture containing glucose with galactose has been shown to accelerate liver glycogen repletion as compared to glucose-only provision. However, the extent to which galactose-glucose combinations influence post-exercise muscle glycogen storage has yet to be determined. Therefore, this study will investigate whether short-term muscle glycogen storage after strenuous endurance exercise is enhanced by combined galactose-glucose or glucose only ingestion as compared to the ingestion of galactose alone.
Interventions
OTHERGlucose and galactose
Young men or women will complete a glycogen depleting bout of exercise followed by the provision of glucose and galactose over 4 hours of recovery before a subsequent bout of exercise.
OTHERGlucose alone
Young men or women will complete a glycogen depleting bout of exercise followed by the provision of glucose-alone over 4 hours of recovery before a subsequent bout of exercise.
OTHERGalactose alone
Young men or women will complete a glycogen depleting bout of exercise followed by the provision of galactose-alone over 4 hours of recovery before a subsequent bout of exercise.
Sponsors
Dairy Management Inc.
University of Birmingham
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
. * Body mass index in the range: 18.5 - 27.5 kg/m2 * Participates in endurance-based exercise (e.g. cycling, running, rowing) at least 3 times per week * Aerobic fitness: VO2max \>45 ml/kg/min (men), \>40 ml/kg/min (women)
Exclusion criteria
* Lidocaine allergy * Current participation in another scientific/clinical study * Bleeding disorder/s * Current or recent smoker to include vaping (last 60 days) * Vegan * Existence of food intolerances * Poor recent health as indicated in the general health questionnaire * Engage in uncommon eating practices (e.g. sustained periods of fasting) * Diagnosed with galactosemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle glycogen synthesis rates (mmol/kg/dm/h) | 4 hours | Muscle glycogen synthesis rates over the post-exercise recovery period |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fat oxidation rates (g/min) | Up to 90 minutes | Fat oxidation during a secondary bout of exercise |
| Plasma glucose (mmol/L) | Up to 6 hours | Plasma glucose during the post-exercise recovery period and during a secondary bout of exercise |
| Serum insulin (mU/L) | Up to 6 hours | Serum insulin during the post-exercise recovery period and during a secondary bout of exercise |
| Plasma galactose (mmol/L) | Up to 6 hours | Plasma galactose during the post-exercise recovery period and during a secondary bout of exercise |
| Carbohydrate oxidation rates (g/min) | Up to 90 minutes | Total, exogenous and endogenous carbohydrate oxidation during a secondary bout of exercise |
| Plasma non-esterified fatty acids (mmol/L) | Up to 6 hours | Plasma non-esterified fatty acids during the post-exercise recovery period and during a secondary bout of exercise |
| Plasma glycerol (umol/L) | Up to 6 hours | Plasma glycerol during the post-exercise recovery period and during a secondary bout of exercise |
| Plasma glucagon (pmol/L) | Up to 6 hours | Plasma glucagon during the post-exercise recovery period and during a secondary bout of exercise |
| Plasma lactate (mmol/L) | Up to 6 hours | Plasma lactate during the post-exercise recovery period and during a secondary bout of exercise |
Countries
United Kingdom
Outcome results
None listed