Neoplasms Malignant
Conditions
Brief summary
The aims of this study examine the immune system, muscle metabolism, and autonomic nervous system response to an acute bout of exercise. Cancer survivors will participate in an acute bout of exercise. Blood samples will be collected before the exercise bout and at two time points after the exercise bout to assess the proposed variables.
Interventions
OTHERExercise
Single session of treadmill walking and resistance exercise
Sponsors
University of Houston
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Between the ages of 40-70 years * At least two years past detectible cancer (two years disease-free survival) * Have received chemotherapy and/or radiation as part of their cancer treatment * All cancers were of the organs/non-blood producing tissues (not blood/hematologic cancers) and while they were an adult (no history of pediatric cancer) * Meeting ACSM-AHA guidelines for exercise (150 minutes per week of cardiorespiratory fitness type exercises and \ two days per week of resistance training), as confirmed by a combination of a physical activity questionnaire and a cardiorespiratory fitness classification of good or higher (age and sex matched) * A BMI between 20-33 kg·m-2 * Able to speak and read English
Exclusion criteria
Participants may not: * Have any contraindications to moderate to vigorous exercise * Have any recent illness or have been instructed not to exercise by a healthcare provider * Participants may not have range of motion restrictions that would prevent them from participating in aerobic or resistance training with proper form (they must be ambulatory) * Be taking medications (prescription or over the counter) known to influence immune function (including daily NSAID's and beta blockers), cholesterol-lowering medications (statins), drugs that increase bone mass (bisphosphonates), or steroids. * Have known cardiovascular, respiratory, metabolic, or renal disease, with the exception of controlled hypertension (as defined by resting BP below 140/90) and/or controlled asthma (self-reported). * Be pregnant * Be unable to complete all visits (i.e. must not be planning to leave the Houston area long-term before concluding their participation in the study) * Fall outside of a BMI range of (20 - 33) * Consume alcohol or recreational drugs for 24h prior to visits * Participants must not have scheduling conflicts that would prevent them from reporting to the laboratory of integrated physiology 2-3 times over the course of the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise-induced response of circulating monocytes | Pre-exercise, change from pre-exercise to immediately post-exercise, change from pre-exercise to 1hr post-exercise, change from immediately post-exercise to 1hr post-exercise | Circulating serum monocyte phenotype before and after one exercise session |
| Exercise-induced response of circulating T cells | Pre-exercise, change from pre-exercise to immediately post-exercise, change from pre-exercise to 1hr post-exercise, change from immediately post-exercise to 1hr post-exercise | Circulating serum T cells phenotype before and after one exercise session |
| Exercise-induced response of circulating Follistatin | Pre-exercise, change from pre-exercise to immediately post-exercise, change from pre-exercise to 1hr post-exercise, change from immediately post-exercise to 1hr post-exercise | Circulating serum follistatin before and after one exercise session |
| Exercise-induced response of circulating GDF-15 | Pre-exercise, change from pre-exercise to immediately post-exercise, change from pre-exercise to 1hr post-exercise, change from immediately post-exercise to 1hr post-exercise | Circulating serum growth differentiation factor 15 before and after one exercise session |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body composition | before exercise | Relative body composition, as calculated from a DEXA scan. Measurement will be used as a descriptive variable and potential covariant |
| Body weight | before exercise | Absolute body weight as measured with an eye level beam. Measurement will be used as a descriptive variable and potential covariant |
Contacts
Primary ContactMelissa Markofski, PhD
Outcome results
None listed