Dose Ranging Study to Assess Efficacy, Safety, Tolerability and Pharmacokinetics of PF-06700841 Topical Cream in Participants With Mild or Moderate Atopic Dermatitis

A PHASE 2B, RANDOMIZED, DOUBLE BLIND, VEHICLE CONTROLLED, PARALLEL GROUP, DOSE RANGING STUDY TO ASSESS THE EFFICACY, SAFETY, TOLERABILITY AND PHARMACOKINETICS OF PF-06700841 CREAM APPLIED ONCE OR TWICE DAILY FOR 6 WEEKS IN PARTICIPANTS WITH MILD OR MODERATE ATOPIC DERMATITIS

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03903822

Enrollment

292

Registered

2019-04-04

Start date

2019-05-13

Completion date

2020-05-07

Last updated

2021-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic Dermatitis

Keywords

Mild-to-Moderate Atopic Dermatitis, topical

Brief summary

This study is being conducted to provide data on efficacy, safety, tolerability and PK of multiple topical formulation concentrations of PF-06700841 topical cream in the treatment of mild to moderate atopic dermatitis (AD). The study is intended to enable selection of the dose and dosing regimen (once daily \[QD\] vs twice daily \[BID\] application) for the future clinical development of topical PF-06700841.

Interventions

DRUGPF-06700841

PF-06700841 topical cream

DRUGVehicle (Placebo)

Vehicle topical cream

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

12 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of Atopic Dermatitis for at least 3 months * Investigator's Global Assessment (IGA) Score of 2 or 3 * Eczema Area Severity Index (EASI) score of 3-21 * Body Surface Area (BSA) of 2-20% * Peak pruritus-Numerical Rating Scale (PPNRS) of Grade 2 or more

Exclusion criteria

* Other forms of dermatological diseases (other than atopic dermatitis) * Fitzpatrick skin type score greater than 5 * Clinically significant abnormal ECG, vital signs, and laboratory values * Infection with HBV, HCV, herpes zoster or tuberculosis

Design outcomes

Primary

Measure	Time frame	Description
Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	Baseline, Week 6	EASI evaluates severity of participant's AD (excluded scalp, palms, soles) based on severity of AD clinical signs and % of body surface area (BSA) affected. Severity of clinical signs of AD (erythema, induration/papulation, excoriation and lichenification) scored separately for each of 4 body regions(head and neck, upper limbs, trunk \[including axillae and groin\] and lower limbs \[including buttocks\]) on4-point scale: 0= absent; 1= mild; 2= moderate; 3= severe. EASI area score was based upon % BSA with AD in each 4 body region: 0 (0%), 1 (\>0 to \<10%), 2 (10 to \<30%), 3 (30 to \<50%), 4 (50 to \<70%), 5 (70 to \<90%) and 6 (90 to 100%). Total EASI score =0.1\Ah\(Eh+Ih+Exh+Lh) + 0.2\Au\(Eu+Iu+ExU+Lu) + 0.3\At\(Et+It+Ext+Lt) + 0.4\Al\(El+Il+Exl+Ll); A = EASI area score; E = erythema; I = induration/papulation; Ex = excoriation; L = lichenification; h = head and neck; u = upper limbs; t = trunk; l = lower limbs. Total EASI score ranged from 0.0 to 72.0, higher scores = greater severity of AD.

Secondary

Measure	Time frame	Description
Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	Baseline, Week 6	EASI evaluates severity of participant's AD (excluded scalp, palms, soles) based on severity of AD clinical signs and % of body surface area (BSA) affected. Severity of clinical signs of AD (erythema, induration/papulation, excoriation and lichenification) scored separately for each of 4 body regions(head and neck, upper limbs, trunk \[including axillae and groin\] and lower limbs \[including buttocks\]) on4-point scale: 0= absent; 1= mild; 2= moderate; 3= severe. EASI area score was based upon % BSA with AD in each 4 body region: 0 (0%), 1 (\>0 to \<10%), 2 (10 to \<30%), 3 (30 to \<50%), 4 (50 to \<70%), 5 (70 to \<90%) and 6 (90 to 100%). Total EASI score =0.1\Ah\(Eh+Ih+Exh+Lh) + 0.2\Au\(Eu+Iu+ExU+Lu) + 0.3\At\(Et+It+Ext+Lt) + 0.4\Al\(El+Il+Exl+Ll); A = EASI area score; E = erythema; I = induration/papulation; Ex = excoriation; L = lichenification; h = head and neck; u = upper limbs; t = trunk; l = lower limbs. Total EASI score ranged from 0.0 to 72.0, higher scores = greater severity of AD.
Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	Baseline, Weeks 1, 2, 3, 4 and 6	The severity of itch (pruritus) due to AD was assessed using a horizontal NRS. Participants at specified time points were asked the following question: How would you rate your itch due to AD at the worst moment during the previous 24 hours? The scale ranged from 0-10, where 0= no itch and 10= worst itch imaginable. Higher scores indicated worse itch.
Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	Baseline, Weeks 1, 2, 3, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)	The severity of itch (pruritus) due to AD was assessed using a horizontal NRS. Participants at specified time points were asked the following question: How would you rate your itch due to AD at the worst moment during the previous 24 hours? The scale ranged from 0-10, where 0= no itch and 10= worst itch imaginable. Higher scores indicated worse itch.
Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	Baseline, Weeks 1, 2, 3, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)	4 body regions were evaluated: head and neck, upper limbs, trunk (including axillae and groin) and lower limbs (including buttocks). Scalp, palms and soles were excluded. BSA was calculated using handprint method. Number of handprints (size of participant's full palmer hand) fitting in the affected area of a body region was estimated. Maximum number of handprints were 10 for head and neck, 20 for upper limbs, 30 for trunk and 40 for lower limbs. Surface area of body region equivalent to 1 handprint: 1 handprint was equal to 10% for head and neck, 5% for upper limbs, 3.33% for trunk and 2.5% for lower limbs. Percent BSA for a body region was calculated as = total number of handprints in a body region \* % surface area equivalent to 1 handprint. Overall % BSA for an individual: arithmetic mean of % BSA of all 4 body regions, ranged from 0 to 100%, with higher values representing greater severity of AD.
Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	Baseline, Weeks 1, 2, 3, 4 and 6	EASI evaluates severity of participant's AD (excluded scalp, palms, soles) based on severity of AD clinical signs and % of body surface area (BSA) affected. Severity of clinical signs of AD (erythema, induration/papulation, excoriation and lichenification) scored separately for each of 4 body regions(head and neck, upper limbs, trunk \[including axillae and groin\] and lower limbs \[including buttocks\]) on4-point scale: 0= absent; 1= mild; 2= moderate; 3= severe. EASI area score was based upon % BSA with AD in each 4 body region: 0 (0%), 1 (\>0 to \<10%), 2 (10 to \<30%), 3 (30 to \<50%), 4 (50 to \<70%), 5 (70 to \<90%) and 6 (90 to 100%). Total EASI score =0.1\Ah\(Eh+Ih+Exh+Lh) + 0.2\Au\(Eu+Iu+ExU+Lu) + 0.3\At\(Et+It+Ext+Lt) + 0.4\Al\(El+Il+Exl+Ll); A = EASI area score; E = erythema; I = induration/papulation; Ex = excoriation; L = lichenification; h = head and neck; u = upper limbs; t = trunk; l = lower limbs. Total EASI score ranged from 0.0 to 72.0, higher scores = greater severity of AD.
Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	Baseline (Day 1) up to at least 28 days after last dose of study drug (approximately up to Week 11)	An AE was any untoward medical occurrence in a participant who received investigational product without regard to possibility of causal relationship. SAE was an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly; medically important events. Treatment-emergent were events between first dose of investigational product and up to 28 days after the last dose of investigational product that were absent before treatment or that worsened relative to pretreatment state. AEs included both SAEs and all non-SAEs.
Number of Participants With Pre-defined Criteria For Vital Signs	Baseline up to Week 6	Pre-defined criteria included: 1) Diastolic blood pressure (DBP), a) sitting DBP: change of \>= 20 millimeter of mercury (mmHg) increase, b) sitting DBP: change of \>=20mmHg decrease, c) supine DBP: less than (\<) 50 mmHg, d) supine DBP: change of \>= 20mmHg increase, e) supine DBP: change of \>= 20mmHg decrease; 2) Systolic blood pressure (SBP), a) sitting SBP: \<90 mmHg, b) sitting SBP: change of \>=30mmHg increase, c) sitting SBP: change of \>=30mmHg decrease, d) supine SBP: change of \>=30mmHg increase, e) supine SBP: change of \>=30mmHg decrease and f) Supine SBP: value \<90mmHg.
Number of Participants With Laboratory Abnormalities	Baseline (Day 1) up to at least 28 days after last dose of study drug (approximately up to Week 11)	Hemoglobin (HGB),hematocrit,erythrocytes (ery.),HDL cholesterol (chl.)\<0.8\lower limit of normal(LLN);reticulocytes (ret.), ret./ery. (%)\<0.5\LLN,\>1.5\upper limit of normal (ULN);ery. mean corpuscular (EMC) volume,EMC HGB,EMC HGB concentration,potassium,chloride,calcium,bicarbonate\<0.9\LLN,\>1.1\ULN;platelets\<0.5\LLN,\>1.75\ULN;leukocytes (leu.),glucose\<0.6\LLN,\>1.5\ULN;lymphocytes (lym.), lym./leu.(%), neutrophils (neu.), neu./leu. (%), protein,albumin \<0.8\LLN,\>1.2\ULN;basophils (bas.), bas./leu.(%), eosinophils (eos.), eos./leu., monocytes (mon.), mon./leu.(%), urate \>1.2\ULN;bilirubin (total, direct, indirect)\>1.5\ULN;aspartate/alanine aminotransferase, gamma glutamyl transferase, lactate dehydrogenase, alkaline phosphatase\>3.0\ULN;urea nitrogen, creatinine, triglycerides, chl.\>1.3\ULN; sodium \<0.95\LLN,\>1.05\ULN; creatine kinase \>2.0\ULN;Urine: pH\<4.5,\>8;glucose, ketones, protein, HGB, urobilinogen,bilirubin,nitrite,leukocyte esterase\>=1;ery., leu.\>= 20;hyaline casts\>1;bacteria\>20.
Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	Baseline up to Week 6	Clinically significant ECG criteria included PR interval: value greater than (\>) 280 millisecond (msec), percentage change greater than equal to (\>=) 25/50 percentage, QRS interval: value \>120 msec, percentage change \>= 50% and QT interval corrected using the Fridericia's formula (QTCF) value 450 msec and 30\<=change\<60.
Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)	—
Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)	—
Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)	—
Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation	Baseline, Week 6	IGA assesses severity of participant's AD on a 5 point scale. 0= clear, no inflammatory signs of AD; 1= almost clear, AD not fully cleared- light pink residual lesions (except post-inflammatory hyperpigmentation), just perceptible erythema, papulation/induration lichenification, excoriation, and no oozing/crusting; 2= mild AD with light red lesions, slight but definite erythema, papulation/induration, lichenification, excoriation and no oozing/crusting; 3= moderate AD with red lesions, moderate erythema, papulation/induration, lichenification, excoriation and slight oozing/crusting and 4= severe AD with deep dark red lesions, severe erythema, papulation/induration, lichenification, excoriation and moderate to severe oozing/crusting. Higher scores indicating more severity of AD. Assessment excluded soles, palms and scalp.
Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)	—
Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)	—
Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)	—
Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)	—
Change From Baseline in Lipids Profile Values at Week 6	Baseline, Week 6	Lipid parameters that were assessed: high density lipoprotein (HDL) cholesterol, triglycerides, cholesterol, low density lipoprotein (LDL) cholesterol.
Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6	Baseline, Week 6	Mean change in total cholesterol/HDL cholesterol ratio was assessed and reported.
Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Baseline, Weeks 2 and 6	—
Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	Baseline, Weeks 2 and 6	—
Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Baseline, Weeks 2 and 6	Blood pressure included supine and sitting systolic and diastolic BP.
Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Baseline, Weeks 2 and 6	—
Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Baseline, Weeks 2 and 6	—
Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1 and any day on of Week 1, 2, 4, 6: pre dose (before application of IP) and post dose (after application of IP); Follow up visit (28 days after last dose of study drug = maximum up to Day 71) and Early termination (anytime within week 11)	Local tolerability skin assessments were performed by the investigator and graded based on severity from grade 0 to 4 as: grade 0=none (no evidence of local intolerance); grade 1=mild (minimal erythema and/or oedema, slight glazed appearance); grade 2= moderate (definite erythema and/or oedema with peeling and/or cracking but needs no adaptation of posology) grade 3=severe (erythema, oedema glazing with fissures, few vesicles or papules consider removing topical agent \[if still in place\]) and grade 4= very severe (strong reaction spreading beyond the treated area, bullous reaction, erosions: removal of topical agent \[if still in place\]). Higher grades indicated worsening of condition. Only those categories in which at least 1 participant had data were reported.
Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)	—

Countries

Australia, Bulgaria, Canada, Denmark, Germany, Hungary, Japan, Latvia, Poland, United States

Participant flow

Participants by arm

Arm	Count
Vehicle Cream Once Daily (QD) Participants or caregivers of participants, topically applied vehicle cream on all eligible AD areas (of participants) once daily for a maximum of 6 weeks. Eligibility of AD areas to be treated were determined on Day 1 by investigator. Participants were followed up for 4 weeks after last dose.	37
PF-06700841 0.1% Cream QD Participants or caregivers of participants, topically applied PF-06700841 0.1 % cream on all eligible AD areas (of participants) once daily for a maximum of 6 weeks. Eligibility of AD areas to be treated were determined on Day 1 by investigator. Participants were followed up for 4 weeks after last dose.	37
PF-06700841 0.3% Cream QD Participants or caregivers of participants, topically applied PF-06700841 0.3 % cream on all eligible AD areas (of participants) once daily for a maximum of 6 weeks. Eligibility of AD areas to be treated were determined on Day 1 by investigator. Participants were followed up for 4 weeks after last dose.	36
PF-06700841 1.0% Cream QD Participants or caregivers of participants, topically applied PF-06700841 1.0 % cream on all eligible AD areas (of participants) once daily for a maximum of 6 weeks. Eligibility of AD areas to be treated were determined on Day 1 by investigator. Participants were followed up for 4 weeks after last dose.	37
PF-06700841 3.0% Cream QD Participants or caregivers of participants, topically applied PF-06700841 3.0 % cream on all eligible AD areas (of participants) once daily for a maximum of 6 weeks. Eligibility of AD areas to be treated were determined on Day 1 by investigator. Participants were followed up for 4 weeks after last dose.	36
Vehicle Cream Twice Daily (BID) Participants or caregivers of participants, topically applied vehicle cream on all eligible AD areas (of participants) twice daily for a maximum of 6 weeks. Eligibility of AD areas to be treated were determined on Day 1 by investigator. Participants were followed up for 4 weeks after last dose.	36
PF-06700841 0.3% Cream BID Participants or caregivers of participants, topically applied PF-06700841 0.3% cream on all eligible AD areas (of participants) twice daily for a maximum of 6 weeks. Eligibility of AD areas to be treated were determined on Day 1 by investigator. Participants were followed up for 4 weeks after last dose.	36
PF-06700841 1.0% Cream BID Participants or caregivers of participants, topically applied PF-06700841 1.0 % cream on all eligible AD areas (of participants) twice daily for a maximum of 6 weeks. Eligibility of AD areas to be treated were determined on Day 1 by investigator. Participants were followed up for 4 weeks after last dose.	37
Total	292

Withdrawals & dropouts

Period	Reason	FG000	FG001	FG002	FG003	FG004	FG005	FG006	FG007
Follow up Phase (4 Weeks)	Adverse Event	3	2	1	1	0	5	1	0
Follow up Phase (4 Weeks)	Lack of Efficacy	0	0	0	0	1	0	0	0
Follow up Phase (4 Weeks)	Lost to Follow-up	2	0	0	0	0	0	1	3
Follow up Phase (4 Weeks)	Other	1	1	0	0	0	0	0	0
Follow up Phase (4 Weeks)	Pregnancy	0	0	0	1	1	0	0	0
Follow up Phase (4 Weeks)	Refused Further Study Procedures	0	0	0	0	0	1	0	0
Follow up Phase (4 Weeks)	Withdrawal by Subject	2	5	3	2	2	2	3	3
Treatment Phase (6 Weeks)	Adverse Event	3	3	1	1	1	6	1	0
Treatment Phase (6 Weeks)	Lack of Efficacy	0	0	0	0	1	1	0	0
Treatment Phase (6 Weeks)	Lost to Follow-up	0	0	0	0	0	0	1	1
Treatment Phase (6 Weeks)	Other	2	1	0	0	1	1	0	0
Treatment Phase (6 Weeks)	Physician Decision	0	2	0	0	0	0	0	0
Treatment Phase (6 Weeks)	Pregnancy	0	0	0	1	1	0	0	0
Treatment Phase (6 Weeks)	Protocol Violation	0	0	0	1	0	0	0	0
Treatment Phase (6 Weeks)	Refused Further Treatment	2	0	0	0	0	1	0	0
Treatment Phase (6 Weeks)	Withdrawal by Subject	2	4	2	2	1	2	3	3

Baseline characteristics

Characteristic	Vehicle Cream Once Daily (QD)	PF-06700841 0.1% Cream QD	PF-06700841 0.3% Cream QD	PF-06700841 1.0% Cream QD	PF-06700841 3.0% Cream QD	Vehicle Cream Twice Daily (BID)	PF-06700841 0.3% Cream BID	PF-06700841 1.0% Cream BID	Total
Age, Continuous	39.1 Years STANDARD_DEVIATION 16.8	40.8 Years STANDARD_DEVIATION 15.35	43.4 Years STANDARD_DEVIATION 16.43	38.4 Years STANDARD_DEVIATION 12.9	40.5 Years STANDARD_DEVIATION 12.3	42.3 Years STANDARD_DEVIATION 18.18	39.4 Years STANDARD_DEVIATION 17.27	38.1 Years STANDARD_DEVIATION 15.34	40.2 Years STANDARD_DEVIATION 15.59
Ethnicity (NIH/OMB) Hispanic or Latino	0 Participants	0 Participants	3 Participants	2 Participants	1 Participants	3 Participants	0 Participants	4 Participants	13 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	37 Participants	37 Participants	32 Participants	35 Participants	35 Participants	33 Participants	35 Participants	33 Participants	277 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants	0 Participants	1 Participants	0 Participants	0 Participants	0 Participants	1 Participants	0 Participants	2 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Asian	4 Participants	8 Participants	4 Participants	8 Participants	10 Participants	9 Participants	9 Participants	7 Participants	59 Participants
Race (NIH/OMB) Black or African American	8 Participants	7 Participants	9 Participants	6 Participants	4 Participants	6 Participants	5 Participants	6 Participants	51 Participants
Race (NIH/OMB) More than one race	0 Participants	0 Participants	2 Participants	2 Participants	1 Participants	0 Participants	0 Participants	0 Participants	5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants	0 Participants	0 Participants	1 Participants	0 Participants	1 Participants	0 Participants	0 Participants	2 Participants
Race (NIH/OMB) Unknown or Not Reported	1 Participants	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants	0 Participants	1 Participants
Race (NIH/OMB) White	24 Participants	22 Participants	21 Participants	20 Participants	21 Participants	20 Participants	22 Participants	24 Participants	174 Participants
Sex: Female, Male Female	20 Participants	19 Participants	24 Participants	23 Participants	15 Participants	19 Participants	16 Participants	20 Participants	156 Participants
Sex: Female, Male Male	17 Participants	18 Participants	12 Participants	14 Participants	21 Participants	17 Participants	20 Participants	17 Participants	136 Participants

Adverse events

Event type	EG000 affected / at risk	EG001 affected / at risk	EG002 affected / at risk	EG003 affected / at risk	EG004 affected / at risk	EG005 affected / at risk	EG006 affected / at risk	EG007 affected / at risk
deaths Total, all-cause mortality	0 / 37	0 / 37	0 / 36	0 / 37	0 / 36	0 / 36	0 / 36	0 / 37
other Total, other adverse events	18 / 37	17 / 37	11 / 36	12 / 37	10 / 36	17 / 36	9 / 36	14 / 37
serious Total, serious adverse events	0 / 37	0 / 37	0 / 36	0 / 37	0 / 36	0 / 36	0 / 36	0 / 37

Outcome results

Primary

Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation

EASI evaluates severity of participant's AD (excluded scalp, palms, soles) based on severity of AD clinical signs and % of body surface area (BSA) affected. Severity of clinical signs of AD (erythema, induration/papulation, excoriation and lichenification) scored separately for each of 4 body regions(head and neck, upper limbs, trunk \[including axillae and groin\] and lower limbs \[including buttocks\]) on4-point scale: 0= absent; 1= mild; 2= moderate; 3= severe. EASI area score was based upon % BSA with AD in each 4 body region: 0 (0%), 1 (\>0 to \<10%), 2 (10 to \<30%), 3 (30 to \<50%), 4 (50 to \<70%), 5 (70 to \<90%) and 6 (90 to 100%). Total EASI score =0.1\*Ah\*(Eh+Ih+Exh+Lh) + 0.2\*Au\*(Eu+Iu+ExU+Lu) + 0.3\*At\*(Et+It+Ext+Lt) + 0.4\*Al\*(El+Il+Exl+Ll); A = EASI area score; E = erythema; I = induration/papulation; Ex = excoriation; L = lichenification; h = head and neck; u = upper limbs; t = trunk; l = lower limbs. Total EASI score ranged from 0.0 to 72.0, higher scores = greater severity of AD.

Time frame: Baseline, Week 6

Population: Full analysis set included all participants who were randomly assigned to study drug and who applied at least 1 dose of study drug. Missing data were imputed with multiple imputation method assuming responses are similar to the corresponding vehicle arm under the MAR assumption

Arm	Measure	Value (LEAST_SQUARES_MEAN)
Vehicle Cream Once Daily (QD)	Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-44.4 Percent change
PF-06700841 0.1% Cream QD	Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-58.3 Percent change
PF-06700841 0.3% Cream QD	Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-64.6 Percent change
PF-06700841 1.0% Cream QD	Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-70.1 Percent change
PF-06700841 3.0% Cream QD	Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-67.9 Percent change
Vehicle Cream Twice Daily (BID)	Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-47.6 Percent change
PF-06700841 0.3% Cream BID	Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-58.6 Percent change
PF-06700841 1.0% Cream BID	Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-75.0 Percent change

Comparison: Analysis of covariance (ANCOVA) contained fixed factors of treatment and baseline value.p-value: 0.10490% CI: [-32.1, 4.3]ANCOVA

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.033490% CI: [-38.3, -2.1]ANCOVA

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.008690% CI: [-43.3, -8]ANCOVA

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.015890% CI: [-41.5, -5.5]ANCOVA

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.087990% CI: [-24.3, 2.4]ANCOVA

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.000490% CI: [-40.7, -14.1]ANCOVA

Secondary

Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Time frame: Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)

Population: Safety analysis set included all participants who were randomly assigned to study drug and who applied at least 1 dose of study drug. Here, Overall Number of Participants Analyzed signifies participants evaluable for this outcome measure and number analyzed signifies participants evaluable for the each specified time point.

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	0.4 Units per liter	Standard Deviation 25.99
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-12.3 Units per liter	Standard Deviation 24.82
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-8.8 Units per liter	Standard Deviation 18.25
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-8.6 Units per liter	Standard Deviation 23.93
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-8.8 Units per liter	Standard Deviation 21.56
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-7.8 Units per liter	Standard Deviation 27.99
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-8.1 Units per liter	Standard Deviation 32.02
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-12.0 Units per liter	Standard Deviation 28.83
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-5.4 Units per liter	Standard Deviation 22.87
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-7.4 Units per liter	Standard Deviation 30.2
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-1.9 Units per liter	Standard Deviation 18.18
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	4.0 Units per liter	Standard Deviation 43.45
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-5.3 Units per liter	Standard Deviation 16.99
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-1.5 Units per liter	Standard Deviation 32.42
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-9.3 Units per liter	Standard Deviation 19.61
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-12.1 Units per liter	Standard Deviation 28.54
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-2.7 Units per liter	Standard Deviation 26.27
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-9.3 Units per liter	Standard Deviation 22.65
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-8.8 Units per liter	Standard Deviation 23.7
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-6.4 Units per liter	Standard Deviation 28.53
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-16.3 Units per liter	Standard Deviation 33.97
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-18.4 Units per liter	Standard Deviation 33.42
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-15.8 Units per liter	Standard Deviation 42.19
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-18.2 Units per liter	Standard Deviation 33.86
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-15.1 Units per liter	Standard Deviation 38.23
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-1.0 Units per liter	Standard Deviation 29.29
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-9.7 Units per liter	Standard Deviation 20.68
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-0.3 Units per liter	Standard Deviation 22.81
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-8.0 Units per liter	Standard Deviation 34.51
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-11.3 Units per liter	Standard Deviation 29.39
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-19.5 Units per liter	Standard Deviation 19.94
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-8.0 Units per liter	Standard Deviation 19.37
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-8.0 Units per liter	Standard Deviation 22.31
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-13.3 Units per liter	Standard Deviation 25.37
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-11.2 Units per liter	Standard Deviation 22.34
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	0.2 Units per liter	Standard Deviation 16.48
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-7.0 Units per liter	Standard Deviation 24.65
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-4.3 Units per liter	Standard Deviation 29.08
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-3.7 Units per liter	Standard Deviation 24.96
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-4.9 Units per liter	Standard Deviation 24.49

Secondary

Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Time frame: Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at follow-up visit	-0.07 Gram per deciliter	Standard Deviation 0.341
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 6	-0.13 Gram per deciliter	Standard Deviation 0.403
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at follow-up visit	-0.06 Gram per deciliter	Standard Deviation 0.247
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 6	-0.08 Gram per deciliter	Standard Deviation 0.259
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein:change at week 2	-0.09 Gram per deciliter	Standard Deviation 0.383
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 1	-0.01 Gram per deciliter	Standard Deviation 0.439
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at week 4	-0.08 Gram per deciliter	Standard Deviation 0.245
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 2	-0.06 Gram per deciliter	Standard Deviation 0.235
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 1	-0.04 Gram per deciliter	Standard Deviation 0.269
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 4	-0.10 Gram per deciliter	Standard Deviation 0.38
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 1	-0.04 Gram per deciliter	Standard Deviation 0.294
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 6	0.13 Gram per deciliter	Standard Deviation 0.379
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at follow-up visit	0.05 Gram per deciliter	Standard Deviation 0.457
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at follow-up visit	0.10 Gram per deciliter	Standard Deviation 0.26
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 2	0.02 Gram per deciliter	Standard Deviation 0.201
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 6	0.08 Gram per deciliter	Standard Deviation 0.245
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 4	0.07 Gram per deciliter	Standard Deviation 0.315
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at week 4	0.07 Gram per deciliter	Standard Deviation 0.172
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 1	-0.05 Gram per deciliter	Standard Deviation 0.205
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein:change at week 2	0.03 Gram per deciliter	Standard Deviation 0.303
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein:change at week 2	-0.18 Gram per deciliter	Standard Deviation 0.402
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 1	-0.14 Gram per deciliter	Standard Deviation 0.433
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 4	-0.08 Gram per deciliter	Standard Deviation 0.429
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 6	-0.19 Gram per deciliter	Standard Deviation 0.452
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at follow-up visit	-0.15 Gram per deciliter	Standard Deviation 0.481
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 1	-0.10 Gram per deciliter	Standard Deviation 0.283
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 2	-0.10 Gram per deciliter	Standard Deviation 0.256
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at week 4	-0.08 Gram per deciliter	Standard Deviation 0.285
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 6	-0.14 Gram per deciliter	Standard Deviation 0.333
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at follow-up visit	-0.09 Gram per deciliter	Standard Deviation 0.277
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at follow-up visit	-0.04 Gram per deciliter	Standard Deviation 0.404
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 6	-0.02 Gram per deciliter	Standard Deviation 0.269
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at follow-up visit	-0.04 Gram per deciliter	Standard Deviation 0.295
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 1	-0.02 Gram per deciliter	Standard Deviation 0.177
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 2	-0.02 Gram per deciliter	Standard Deviation 0.204
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 6	0.01 Gram per deciliter	Standard Deviation 0.368
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 1	-0.04 Gram per deciliter	Standard Deviation 0.264
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at week 4	0.01 Gram per deciliter	Standard Deviation 0.239
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 4	-0.03 Gram per deciliter	Standard Deviation 0.341
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein:change at week 2	-0.01 Gram per deciliter	Standard Deviation 0.275
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein:change at week 2	0.01 Gram per deciliter	Standard Deviation 0.561
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 2	-0.01 Gram per deciliter	Standard Deviation 0.283
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at follow-up visit	0.03 Gram per deciliter	Standard Deviation 0.481
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 6	-0.03 Gram per deciliter	Standard Deviation 0.405
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 1	-0.03 Gram per deciliter	Standard Deviation 0.421
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 6	-0.00 Gram per deciliter	Standard Deviation 0.218
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 1	0.00 Gram per deciliter	Standard Deviation 0.256
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 4	-0.04 Gram per deciliter	Standard Deviation 0.465
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at week 4	0.04 Gram per deciliter	Standard Deviation 0.292
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at follow-up visit	-0.01 Gram per deciliter	Standard Deviation 0.346
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 6	-0.10 Gram per deciliter	Standard Deviation 0.424
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at follow-up visit	-0.18 Gram per deciliter	Standard Deviation 0.471
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 1	-0.05 Gram per deciliter	Standard Deviation 0.218
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein:change at week 2	0.02 Gram per deciliter	Standard Deviation 0.503
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 2	0.02 Gram per deciliter	Standard Deviation 0.266
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at follow-up visit	-0.09 Gram per deciliter	Standard Deviation 0.262
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at week 4	-0.10 Gram per deciliter	Standard Deviation 0.232
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 1	-0.10 Gram per deciliter	Standard Deviation 0.36
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 6	-0.03 Gram per deciliter	Standard Deviation 0.252
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 4	-0.18 Gram per deciliter	Standard Deviation 0.292
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 1	-0.03 Gram per deciliter	Standard Deviation 0.246
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at follow-up visit	-0.09 Gram per deciliter	Standard Deviation 0.398
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at week 4	-0.08 Gram per deciliter	Standard Deviation 0.18
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 1	-0.01 Gram per deciliter	Standard Deviation 0.344
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at follow-up visit	-0.02 Gram per deciliter	Standard Deviation 0.211
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein:change at week 2	-0.04 Gram per deciliter	Standard Deviation 0.286
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 6	-0.07 Gram per deciliter	Standard Deviation 0.244
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 4	-0.15 Gram per deciliter	Standard Deviation 0.242
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 2	-0.03 Gram per deciliter	Standard Deviation 0.174
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 6	-0.09 Gram per deciliter	Standard Deviation 0.368
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 1	0.00 Gram per deciliter	Standard Deviation 0.169
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 6	-0.05 Gram per deciliter	Standard Deviation 0.227
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at follow-up visit	0.02 Gram per deciliter	Standard Deviation 0.299
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at week 4	0.03 Gram per deciliter	Standard Deviation 0.224
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 4	0.03 Gram per deciliter	Standard Deviation 0.28
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin: change at follow-up visit	0.06 Gram per deciliter	Standard Deviation 0.181
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 1	-0.02 Gram per deciliter	Standard Deviation 0.301
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Albumin:change at week 2	-0.06 Gram per deciliter	Standard Deviation 0.202
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein:change at week 2	-0.10 Gram per deciliter	Standard Deviation 0.299
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Protein: change at week 6	-0.09 Gram per deciliter	Standard Deviation 0.31

Secondary

Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Time frame: Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 4	0.01 Milliequivalents per liter	Standard Deviation 0.389
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 1	0.13 Milliequivalents per liter	Standard Deviation 2.548
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 1	-0.00 Milliequivalents per liter	Standard Deviation 0.363
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at follow-up visit	0.6 Milliequivalents per liter	Standard Deviation 2.97
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 6	0.52 Milliequivalents per liter	Standard Deviation 2.56
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 6	-0.8 Milliequivalents per liter	Standard Deviation 2.31
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium:change at week 2	-0.14 Milliequivalents per liter	Standard Deviation 0.367
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at follow-up visit	-0.02 Milliequivalents per liter	Standard Deviation 2.916
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 6	-0.09 Milliequivalents per liter	Standard Deviation 0.373
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 4	0.21 Milliequivalents per liter	Standard Deviation 2.739
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride:change at week 6	-0.6 Milliequivalents per liter	Standard Deviation 1.98
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 1	0.1 Milliequivalents per liter	Standard Deviation 2.34
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 4	0.3 Milliequivalents per liter	Standard Deviation 2.05
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at follow up	-0.4 Milliequivalents per liter	Standard Deviation 3.26
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 2	0.08 Milliequivalents per liter	Standard Deviation 2.229
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 4	-0.3 Milliequivalents per liter	Standard Deviation 2.7
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 2	-0.5 Milliequivalents per liter	Standard Deviation 2.23
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 2	-0.2 Milliequivalents per liter	Standard Deviation 2.52
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at follow-up visit	-0.11 Milliequivalents per liter	Standard Deviation 0.379
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 1	0.1 Milliequivalents per liter	Standard Deviation 2.11
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 1	-0.38 Milliequivalents per liter	Standard Deviation 1.759
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 1	0.08 Milliequivalents per liter	Standard Deviation 0.282
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium:change at week 2	0.04 Milliequivalents per liter	Standard Deviation 0.298
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 2	-0.3 Milliequivalents per liter	Standard Deviation 1.89
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 1	-0.0 Milliequivalents per liter	Standard Deviation 1.77
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 6	-0.44 Milliequivalents per liter	Standard Deviation 2.598
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 4	0.05 Milliequivalents per liter	Standard Deviation 2.128
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 2	-0.40 Milliequivalents per liter	Standard Deviation 2.151
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 4	0.6 Milliequivalents per liter	Standard Deviation 1.83
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at follow-up visit	0.66 Milliequivalents per liter	Standard Deviation 2.209
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 4	-0.06 Milliequivalents per liter	Standard Deviation 0.285
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at follow-up visit	-0.3 Milliequivalents per liter	Standard Deviation 2.16
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 6	0.03 Milliequivalents per liter	Standard Deviation 0.295
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 6	0.0 Milliequivalents per liter	Standard Deviation 2.39
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride:change at week 6	0.1 Milliequivalents per liter	Standard Deviation 2.27
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 4	0.6 Milliequivalents per liter	Standard Deviation 1.89
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at follow up	0.5 Milliequivalents per liter	Standard Deviation 2.5
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at follow-up visit	0.10 Milliequivalents per liter	Standard Deviation 0.375
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 2	-0.2 Milliequivalents per liter	Standard Deviation 2.08
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 1	0.3 Milliequivalents per liter	Standard Deviation 1.86
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 6	0.66 Milliequivalents per liter	Standard Deviation 2.132
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 1	-0.7 Milliequivalents per liter	Standard Deviation 2.04
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 2	-0.1 Milliequivalents per liter	Standard Deviation 2.39
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 4	-0.2 Milliequivalents per liter	Standard Deviation 2.44
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 6	-0.2 Milliequivalents per liter	Standard Deviation 2.23
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at follow up	-0.1 Milliequivalents per liter	Standard Deviation 2.45
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 1	0.03 Milliequivalents per liter	Standard Deviation 0.372
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium:change at week 2	-0.07 Milliequivalents per liter	Standard Deviation 0.338
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 1	0.3 Milliequivalents per liter	Standard Deviation 1.57
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 2	0.7 Milliequivalents per liter	Standard Deviation 2.03
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 4	0.2 Milliequivalents per liter	Standard Deviation 2.68
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 4	-0.02 Milliequivalents per liter	Standard Deviation 0.35
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride:change at week 6	0.0 Milliequivalents per liter	Standard Deviation 2.34
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 1	-0.20 Milliequivalents per liter	Standard Deviation 1.965
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 6	-0.06 Milliequivalents per liter	Standard Deviation 0.332
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at follow-up visit	0.8 Milliequivalents per liter	Standard Deviation 2.64
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 2	-0.51 Milliequivalents per liter	Standard Deviation 1.956
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 4	-0.24 Milliequivalents per liter	Standard Deviation 2.484
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at follow-up visit	0.03 Milliequivalents per liter	Standard Deviation 0.394
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at follow-up visit	0.41 Milliequivalents per liter	Standard Deviation 2.056
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at follow-up visit	0.1 Milliequivalents per liter	Standard Deviation 2.41
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 2	-0.2 Milliequivalents per liter	Standard Deviation 2.18
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 2	0.2 Milliequivalents per liter	Standard Deviation 2.5
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 1	0.02 Milliequivalents per liter	Standard Deviation 0.347
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 1	-0.18 Milliequivalents per liter	Standard Deviation 1.768
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 4	-0.01 Milliequivalents per liter	Standard Deviation 0.327
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at follow up	-0.3 Milliequivalents per liter	Standard Deviation 2.41
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium:change at week 2	0.04 Milliequivalents per liter	Standard Deviation 0.359
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride:change at week 6	-0.5 Milliequivalents per liter	Standard Deviation 2.44
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 6	0.27 Milliequivalents per liter	Standard Deviation 2.204
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 1	-0.6 Milliequivalents per liter	Standard Deviation 2.17
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 6	0.03 Milliequivalents per liter	Standard Deviation 0.407
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at follow-up visit	0.75 Milliequivalents per liter	Standard Deviation 2.386
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 4	0.34 Milliequivalents per liter	Standard Deviation 1.868
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at follow-up visit	0.04 Milliequivalents per liter	Standard Deviation 0.351
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 6	-0.9 Milliequivalents per liter	Standard Deviation 2.4
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 4	-0.4 Milliequivalents per liter	Standard Deviation 2.23
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 2	0.10 Milliequivalents per liter	Standard Deviation 2.129
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 1	0.0 Milliequivalents per liter	Standard Deviation 2.54
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 4	-0.7 Milliequivalents per liter	Standard Deviation 2.71
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 6	0.12 Milliequivalents per liter	Standard Deviation 2.407
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at follow-up visit	-0.4 Milliequivalents per liter	Standard Deviation 2.9
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 1	0.28 Milliequivalents per liter	Standard Deviation 1.638
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 6	-0.06 Milliequivalents per liter	Standard Deviation 0.262
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 2	-0.2 Milliequivalents per liter	Standard Deviation 2.87
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 1	0.0 Milliequivalents per liter	Standard Deviation 2.66
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 1	0.07 Milliequivalents per liter	Standard Deviation 0.343
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at follow-up visit	0.12 Milliequivalents per liter	Standard Deviation 0.358
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 4	-0.3 Milliequivalents per liter	Standard Deviation 2.16
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 4	-0.4 Milliequivalents per liter	Standard Deviation 3.08
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 2	-0.4 Milliequivalents per liter	Standard Deviation 3.61
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 4	0.02 Milliequivalents per liter	Standard Deviation 2.011
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 6	-0.9 Milliequivalents per liter	Standard Deviation 3.55
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 1	-0.4 Milliequivalents per liter	Standard Deviation 3.5
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride:change at week 6	-0.4 Milliequivalents per liter	Standard Deviation 3.05
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 4	0.05 Milliequivalents per liter	Standard Deviation 0.375
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium:change at week 2	0.07 Milliequivalents per liter	Standard Deviation 0.346
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 2	-0.13 Milliequivalents per liter	Standard Deviation 1.931
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at follow up	-0.8 Milliequivalents per liter	Standard Deviation 3.59
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at follow-up visit	0.43 Milliequivalents per liter	Standard Deviation 2.162
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at follow up	0.7 Milliequivalents per liter	Standard Deviation 1.94
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 1	0.6 Milliequivalents per liter	Standard Deviation 2.11
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 6	0.63 Milliequivalents per liter	Standard Deviation 2.096
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 2	0.4 Milliequivalents per liter	Standard Deviation 2.7
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 4	0.3 Milliequivalents per liter	Standard Deviation 3.28
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 6	0.9 Milliequivalents per liter	Standard Deviation 2.5
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 4	-0.09 Milliequivalents per liter	Standard Deviation 0.3
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride:change at week 6	0.5 Milliequivalents per liter	Standard Deviation 2.93
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 4	-0.4 Milliequivalents per liter	Standard Deviation 2.72
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 1	0.09 Milliequivalents per liter	Standard Deviation 2.209
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 6	-0.06 Milliequivalents per liter	Standard Deviation 0.309
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at follow-up visit	1.3 Milliequivalents per liter	Standard Deviation 2.11
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 1	0.01 Milliequivalents per liter	Standard Deviation 0.337
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 2	-0.15 Milliequivalents per liter	Standard Deviation 2.341
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 2	-0.2 Milliequivalents per liter	Standard Deviation 2.61
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at follow-up visit	0.08 Milliequivalents per liter	Standard Deviation 1.643
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 4	0.14 Milliequivalents per liter	Standard Deviation 1.286
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 1	0.4 Milliequivalents per liter	Standard Deviation 1.97
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at follow-up visit	0.05 Milliequivalents per liter	Standard Deviation 0.293
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium:change at week 2	0.00 Milliequivalents per liter	Standard Deviation 0.245
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 1	0.0 Milliequivalents per liter	Standard Deviation 2.08
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at follow up	-0.1 Milliequivalents per liter	Standard Deviation 2.46
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at follow-up visit	0.18 Milliequivalents per liter	Standard Deviation 2.3
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 6	-0.19 Milliequivalents per liter	Standard Deviation 2.038
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 6	-0.1 Milliequivalents per liter	Standard Deviation 2.23
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 4	-0.03 Milliequivalents per liter	Standard Deviation 0.415
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at follow-up visit	-0.09 Milliequivalents per liter	Standard Deviation 0.475
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 2	-0.60 Milliequivalents per liter	Standard Deviation 2.354
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 1	0.00 Milliequivalents per liter	Standard Deviation 0.429
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 1	0.5 Milliequivalents per liter	Standard Deviation 2.02
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 4	-0.00 Milliequivalents per liter	Standard Deviation 2.695
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 1	-0.21 Milliequivalents per liter	Standard Deviation 2.388
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 6	-0.10 Milliequivalents per liter	Standard Deviation 0.355
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride:change at week 6	0.9 Milliequivalents per liter	Standard Deviation 2.73
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 4	-0.1 Milliequivalents per liter	Standard Deviation 1.77
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 2	-0.5 Milliequivalents per liter	Standard Deviation 2.2
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 2	0.4 Milliequivalents per liter	Standard Deviation 2.15
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at follow-up visit	0.3 Milliequivalents per liter	Standard Deviation 2.35
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 4	1.0 Milliequivalents per liter	Standard Deviation 2.21
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium:change at week 2	-0.16 Milliequivalents per liter	Standard Deviation 0.438
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at follow-up visit	1.09 Milliequivalents per liter	Standard Deviation 2.049
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 2	-0.3 Milliequivalents per liter	Standard Deviation 3.45
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 1	0.5 Milliequivalents per liter	Standard Deviation 2.83
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 4	-0.3 Milliequivalents per liter	Standard Deviation 3.28
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 4	0.26 Milliequivalents per liter	Standard Deviation 0.35
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 2	-0.07 Milliequivalents per liter	Standard Deviation 1.828
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium:change at week 2	-0.02 Milliequivalents per liter	Standard Deviation 0.322
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 6	-0.20 Milliequivalents per liter	Standard Deviation 2.217
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 4	0.02 Milliequivalents per liter	Standard Deviation 1.704
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 4	-0.2 Milliequivalents per liter	Standard Deviation 2.57
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at week 1	-0.1 Milliequivalents per liter	Standard Deviation 3.39
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium: change at follow up	0.1 Milliequivalents per liter	Standard Deviation 3.32
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at follow-up visit	0.26 Milliequivalents per liter	Standard Deviation 0.46
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 1	0.20 Milliequivalents per liter	Standard Deviation 0.464
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Sodium:change at week 6	-0.5 Milliequivalents per liter	Standard Deviation 2.49
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at week 2	0.2 Milliequivalents per liter	Standard Deviation 2.99
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Bicarbonate: change at week 1	-0.02 Milliequivalents per liter	Standard Deviation 1.651
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Potassium: change at week 6	0.09 Milliequivalents per liter	Standard Deviation 0.388
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride: change at follow-up visit	0.4 Milliequivalents per liter	Standard Deviation 3.16
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Chloride:change at week 6	0.0 Milliequivalents per liter	Standard Deviation 2.32

Secondary

Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Time frame: Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 2	-0.08 Microgram per deciliter	Standard Deviation 0.417
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium:change at week 1	0.01 Microgram per deciliter	Standard Deviation 0.419
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate:change at week 1	0.16 Microgram per deciliter	Standard Deviation 0.807
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at follow-up visit	0.0 Microgram per deciliter	Standard Deviation 3.17
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at follow -up visit	4.5 Microgram per deciliter	Standard Deviation 11.58
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 2	0.8 Microgram per deciliter	Standard Deviation 3.89
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at follow-up visit	0.00 Microgram per deciliter	Standard Deviation 0.317
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 6	-0.04 Microgram per deciliter	Standard Deviation 0.355
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 4	0.6 Microgram per deciliter	Standard Deviation 3.39
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 4	7.3 Microgram per deciliter	Standard Deviation 15.6
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 6	0.13 Microgram per deciliter	Standard Deviation 0.728
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 1	0.9 Microgram per deciliter	Standard Deviation 4.57
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 2	9.7 Microgram per deciliter	Standard Deviation 23.71
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 4	-0.04 Microgram per deciliter	Standard Deviation 0.354
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at follow- up visit	-0.11 Microgram per deciliter	Standard Deviation 0.721
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose:change at week 1	4.9 Microgram per deciliter	Standard Deviation 8.73
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 4	0.21 Microgram per deciliter	Standard Deviation 0.497
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 2	0.30 Microgram per deciliter	Standard Deviation 0.99
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 6	0.7 Microgram per deciliter	Standard Deviation 2.84
Vehicle Cream Once Daily (QD)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 6	3.5 Microgram per deciliter	Standard Deviation 9.19
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 4	0.14 Microgram per deciliter	Standard Deviation 0.731
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium:change at week 1	0.01 Microgram per deciliter	Standard Deviation 0.259
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 6	0.07 Microgram per deciliter	Standard Deviation 0.984
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate:change at week 1	0.01 Microgram per deciliter	Standard Deviation 0.606
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at follow- up visit	-0.33 Microgram per deciliter	Standard Deviation 0.753
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 2	1.2 Microgram per deciliter	Standard Deviation 17.34
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at follow-up visit	-0.3 Microgram per deciliter	Standard Deviation 3.13
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 2	-0.11 Microgram per deciliter	Standard Deviation 0.655
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at follow -up visit	2.2 Microgram per deciliter	Standard Deviation 11.45
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 2	0.0 Microgram per deciliter	Standard Deviation 2.71
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 1	0.6 Microgram per deciliter	Standard Deviation 3.04
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at follow-up visit	-0.01 Microgram per deciliter	Standard Deviation 0.345
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose:change at week 1	5.7 Microgram per deciliter	Standard Deviation 13.97
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 6	0.10 Microgram per deciliter	Standard Deviation 0.303
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 6	2.4 Microgram per deciliter	Standard Deviation 17.55
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 4	0.11 Microgram per deciliter	Standard Deviation 0.329
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 4	0.5 Microgram per deciliter	Standard Deviation 12.5
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 2	0.00 Microgram per deciliter	Standard Deviation 0.268
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 4	0.0 Microgram per deciliter	Standard Deviation 3.04
PF-06700841 0.1% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 6	-0.2 Microgram per deciliter	Standard Deviation 3.11
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 6	-1.7 Microgram per deciliter	Standard Deviation 10.62
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 1	0.1 Microgram per deciliter	Standard Deviation 3.12
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 2	0.6 Microgram per deciliter	Standard Deviation 3.54
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 6	-0.02 Microgram per deciliter	Standard Deviation 0.831
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 4	-0.0 Microgram per deciliter	Standard Deviation 2.67
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 6	-0.6 Microgram per deciliter	Standard Deviation 3.61
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at follow- up visit	0.05 Microgram per deciliter	Standard Deviation 0.763
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at follow-up visit	0.4 Microgram per deciliter	Standard Deviation 2.6
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium:change at week 1	-0.06 Microgram per deciliter	Standard Deviation 0.377
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate:change at week 1	0.16 Microgram per deciliter	Standard Deviation 0.678
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 2	-0.10 Microgram per deciliter	Standard Deviation 0.362
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 2	0.12 Microgram per deciliter	Standard Deviation 0.617
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 4	0.06 Microgram per deciliter	Standard Deviation 0.756
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at follow-up visit	-0.08 Microgram per deciliter	Standard Deviation 0.409
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose:change at week 1	3.4 Microgram per deciliter	Standard Deviation 14.62
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 2	0.6 Microgram per deciliter	Standard Deviation 10.97
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 4	-1.2 Microgram per deciliter	Standard Deviation 15.86
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 4	-0.07 Microgram per deciliter	Standard Deviation 0.345
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 6	-0.21 Microgram per deciliter	Standard Deviation 0.393
PF-06700841 0.3% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at follow -up visit	4.8 Microgram per deciliter	Standard Deviation 13.28
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 2	-0.03 Microgram per deciliter	Standard Deviation 0.649
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 6	2.1 Microgram per deciliter	Standard Deviation 13.8
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 4	1.4 Microgram per deciliter	Standard Deviation 3.06
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at follow-up visit	0.00 Microgram per deciliter	Standard Deviation 0.323
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 4	-0.06 Microgram per deciliter	Standard Deviation 0.621
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 2	0.9 Microgram per deciliter	Standard Deviation 3.18
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 1	1.0 Microgram per deciliter	Standard Deviation 3.19
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate:change at week 1	-0.01 Microgram per deciliter	Standard Deviation 0.561
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 6	0.03 Microgram per deciliter	Standard Deviation 0.315
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium:change at week 1	-0.02 Microgram per deciliter	Standard Deviation 0.248
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at follow- up visit	-0.21 Microgram per deciliter	Standard Deviation 0.554
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 4	4.5 Microgram per deciliter	Standard Deviation 13.99
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 6	0.9 Microgram per deciliter	Standard Deviation 3.27
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at follow -up visit	4.6 Microgram per deciliter	Standard Deviation 14.77
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 2	0.05 Microgram per deciliter	Standard Deviation 0.296
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 4	0.05 Microgram per deciliter	Standard Deviation 0.272
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 2	3.2 Microgram per deciliter	Standard Deviation 12.63
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 6	0.06 Microgram per deciliter	Standard Deviation 0.63
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose:change at week 1	4.5 Microgram per deciliter	Standard Deviation 8.6
PF-06700841 1.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at follow-up visit	1.2 Microgram per deciliter	Standard Deviation 4.22
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 6	0.3 Microgram per deciliter	Standard Deviation 3.82
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium:change at week 1	0.07 Microgram per deciliter	Standard Deviation 0.386
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate:change at week 1	0.00 Microgram per deciliter	Standard Deviation 0.739
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at follow -up visit	6.0 Microgram per deciliter	Standard Deviation 13.79
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 2	-0.15 Microgram per deciliter	Standard Deviation 0.842
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 4	0.5 Microgram per deciliter	Standard Deviation 3.84
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 4	-0.14 Microgram per deciliter	Standard Deviation 0.856
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at follow-up visit	0.10 Microgram per deciliter	Standard Deviation 0.441
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose:change at week 1	4.4 Microgram per deciliter	Standard Deviation 16.14
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 2	0.07 Microgram per deciliter	Standard Deviation 0.423
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 2	3.1 Microgram per deciliter	Standard Deviation 10
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 6	-0.02 Microgram per deciliter	Standard Deviation 0.649
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 4	0.00 Microgram per deciliter	Standard Deviation 0.376
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 4	2.8 Microgram per deciliter	Standard Deviation 20.2
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 1	1.0 Microgram per deciliter	Standard Deviation 3.05
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 6	0.00 Microgram per deciliter	Standard Deviation 0.397
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 2	0.5 Microgram per deciliter	Standard Deviation 3.63
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 6	-0.5 Microgram per deciliter	Standard Deviation 9.77
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at follow- up visit	-0.02 Microgram per deciliter	Standard Deviation 0.81
PF-06700841 3.0% Cream QD	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at follow-up visit	0.2 Microgram per deciliter	Standard Deviation 2.87
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at follow-up visit	0.8 Microgram per deciliter	Standard Deviation 3.78
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 4	1.3 Microgram per deciliter	Standard Deviation 24.01
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 2	0.6 Microgram per deciliter	Standard Deviation 4.19
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 1	0.2 Microgram per deciliter	Standard Deviation 2.19
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at follow-up visit	-0.05 Microgram per deciliter	Standard Deviation 0.419
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 2	0.27 Microgram per deciliter	Standard Deviation 1.025
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 4	-0.08 Microgram per deciliter	Standard Deviation 0.309
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 4	0.22 Microgram per deciliter	Standard Deviation 0.806
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at follow- up visit	0.02 Microgram per deciliter	Standard Deviation 0.59
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate:change at week 1	0.05 Microgram per deciliter	Standard Deviation 0.661
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose:change at week 1	4.5 Microgram per deciliter	Standard Deviation 29.9
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 6	0.06 Microgram per deciliter	Standard Deviation 0.534
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at follow -up visit	6.2 Microgram per deciliter	Standard Deviation 16.75
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 4	-0.7 Microgram per deciliter	Standard Deviation 2.96
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 6	-3.4 Microgram per deciliter	Standard Deviation 16.37
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 6	-0.8 Microgram per deciliter	Standard Deviation 3.24
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 2	-1.9 Microgram per deciliter	Standard Deviation 13.51
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 2	0.03 Microgram per deciliter	Standard Deviation 0.389
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium:change at week 1	-0.02 Microgram per deciliter	Standard Deviation 0.303
Vehicle Cream Twice Daily (BID)	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 6	-0.05 Microgram per deciliter	Standard Deviation 0.335
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at follow -up visit	9.1 Microgram per deciliter	Standard Deviation 17.21
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 4	1.3 Microgram per deciliter	Standard Deviation 2.81
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose:change at week 1	5.6 Microgram per deciliter	Standard Deviation 13.14
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 1	0.4 Microgram per deciliter	Standard Deviation 3.38
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 2	-0.10 Microgram per deciliter	Standard Deviation 0.293
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 6	-0.11 Microgram per deciliter	Standard Deviation 0.827
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 2	7.9 Microgram per deciliter	Standard Deviation 16.67
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate:change at week 1	-0.02 Microgram per deciliter	Standard Deviation 0.704
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at follow-up visit	0.5 Microgram per deciliter	Standard Deviation 3.42
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 4	-0.03 Microgram per deciliter	Standard Deviation 0.257
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 2	0.8 Microgram per deciliter	Standard Deviation 2.99
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at follow- up visit	-0.08 Microgram per deciliter	Standard Deviation 0.677
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 6	-0.05 Microgram per deciliter	Standard Deviation 0.464
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium:change at week 1	-0.01 Microgram per deciliter	Standard Deviation 0.295
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 6	0.2 Microgram per deciliter	Standard Deviation 3.52
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 6	4.3 Microgram per deciliter	Standard Deviation 12.23
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 4	-0.21 Microgram per deciliter	Standard Deviation 0.663
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 4	10.7 Microgram per deciliter	Standard Deviation 26.13
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 2	-0.03 Microgram per deciliter	Standard Deviation 0.718
PF-06700841 0.3% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at follow-up visit	0.01 Microgram per deciliter	Standard Deviation 0.378
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 6	-0.4 Microgram per deciliter	Standard Deviation 3.69
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 1	-0.1 Microgram per deciliter	Standard Deviation 2.65
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 2	2.7 Microgram per deciliter	Standard Deviation 18.07
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at follow- up visit	-0.20 Microgram per deciliter	Standard Deviation 0.989
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate:change at week 1	-0.14 Microgram per deciliter	Standard Deviation 0.89
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 4	3.4 Microgram per deciliter	Standard Deviation 18.33
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose:change at week 1	3.3 Microgram per deciliter	Standard Deviation 13.58
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 4	-0.2 Microgram per deciliter	Standard Deviation 3.61
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 2	-0.37 Microgram per deciliter	Standard Deviation 1.059
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at week 6	1.5 Microgram per deciliter	Standard Deviation 12.62
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 2	-0.01 Microgram per deciliter	Standard Deviation 0.244
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 4	0.10 Microgram per deciliter	Standard Deviation 0.341
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Glucose: change at follow -up visit	2.0 Microgram per deciliter	Standard Deviation 22.43
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at week 2	0.4 Microgram per deciliter	Standard Deviation 3.28
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urea nitrogen: change at follow-up visit	0.1 Microgram per deciliter	Standard Deviation 3.78
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium:change at week 1	0.09 Microgram per deciliter	Standard Deviation 0.318
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 6	-0.21 Microgram per deciliter	Standard Deviation 1.084
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Urate: change at week 4	-0.16 Microgram per deciliter	Standard Deviation 0.713
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at follow-up visit	0.05 Microgram per deciliter	Standard Deviation 0.356
PF-06700841 1.0% Cream BID	Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Calcium: change at week 6	-0.04 Microgram per deciliter	Standard Deviation 0.337

Secondary

Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation

Time frame: Baseline, Week 6

Arm	Measure	Value (LEAST_SQUARES_MEAN)
Vehicle Cream Once Daily (QD)	Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-3.2 Units on a scale
PF-06700841 0.1% Cream QD	Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-4.5 Units on a scale
PF-06700841 0.3% Cream QD	Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-4.6 Units on a scale
PF-06700841 1.0% Cream QD	Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-4.8 Units on a scale
PF-06700841 3.0% Cream QD	Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-5.5 Units on a scale
Vehicle Cream Twice Daily (BID)	Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-3.6 Units on a scale
PF-06700841 0.3% Cream BID	Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-4.4 Units on a scale
PF-06700841 1.0% Cream BID	Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation	-5.3 Units on a scale

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.048890% CI: [-2.61, -0.01]ANCOVA

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.041390% CI: [-2.66, -0.07]ANCOVA

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.0290% CI: [-2.86, -0.32]ANCOVA

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.001190% CI: [-3.58, -1.08]ANCOVA

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.072790% CI: [-1.66, 0.1]ANCOVA

Comparison: ANCOVA contained fixed factors of treatment and baseline value.p-value: 0.00190% CI: [-2.52, -0.77]ANCOVA

Secondary

Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6

Time frame: Baseline, Weeks 2 and 6

Population: Safety analysis set included all participants who were randomly assigned to study drug and who applied at least 1 dose of study drug. Here, number analyzed signifies participants evaluable for the each specified time point.

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 6	0.3 Beats per minute	Standard Deviation 6.19
Vehicle Cream Once Daily (QD)	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Baseline	66.8 Beats per minute	Standard Deviation 11.45
Vehicle Cream Once Daily (QD)	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 2	0.7 Beats per minute	Standard Deviation 10.05
PF-06700841 0.1% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 6	-1.1 Beats per minute	Standard Deviation 7.65
PF-06700841 0.1% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Baseline	66.9 Beats per minute	Standard Deviation 9.33
PF-06700841 0.1% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 2	-0.5 Beats per minute	Standard Deviation 8.03
PF-06700841 0.3% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Baseline	68.4 Beats per minute	Standard Deviation 14.66
PF-06700841 0.3% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 6	-1.7 Beats per minute	Standard Deviation 9.06
PF-06700841 0.3% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 2	-1.8 Beats per minute	Standard Deviation 11.53
PF-06700841 1.0% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Baseline	64.9 Beats per minute	Standard Deviation 9.05
PF-06700841 1.0% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 2	-0.6 Beats per minute	Standard Deviation 7.88
PF-06700841 1.0% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 6	0.8 Beats per minute	Standard Deviation 8.53
PF-06700841 3.0% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 2	1.9 Beats per minute	Standard Deviation 8.01
PF-06700841 3.0% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Baseline	64.9 Beats per minute	Standard Deviation 12.26
PF-06700841 3.0% Cream QD	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 6	-0.3 Beats per minute	Standard Deviation 8.46
Vehicle Cream Twice Daily (BID)	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 2	2.2 Beats per minute	Standard Deviation 8.76
Vehicle Cream Twice Daily (BID)	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Baseline	66.9 Beats per minute	Standard Deviation 12.03
Vehicle Cream Twice Daily (BID)	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 6	-0.8 Beats per minute	Standard Deviation 8.23
PF-06700841 0.3% Cream BID	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 2	1.7 Beats per minute	Standard Deviation 9.13
PF-06700841 0.3% Cream BID	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Baseline	68.2 Beats per minute	Standard Deviation 12.11
PF-06700841 0.3% Cream BID	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 6	0.5 Beats per minute	Standard Deviation 8.76
PF-06700841 1.0% Cream BID	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Baseline	68.1 Beats per minute	Standard Deviation 12.48
PF-06700841 1.0% Cream BID	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 2	1.7 Beats per minute	Standard Deviation 12.52
PF-06700841 1.0% Cream BID	Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6	Change at week 6	-0.4 Beats per minute	Standard Deviation 12.06

Secondary

Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Time frame: Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 1	0.0 10^12*cells per liter	Standard Deviation 0.02
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at follow-up visit	0.03 10^12*cells per liter	Standard Deviation 0.22
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 6	-0.04 10^12*cells per liter	Standard Deviation 0.247
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 1	0.03 10^12*cells per liter	Standard Deviation 0.261
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at follow-up visit	-0.0 10^12*cells per liter	Standard Deviation 0.02
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 6	-0.0 10^12*cells per liter	Standard Deviation 0.02
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 2	-0.05 10^12*cells per liter	Standard Deviation 0.234
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 4	0.0 10^12*cells per liter	Standard Deviation 0.03
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 2	-0.0 10^12*cells per liter	Standard Deviation 0.02
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 4	-0.01 10^12*cells per liter	Standard Deviation 0.216
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at follow-up visit	0.02 10^12*cells per liter	Standard Deviation 0.244
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 4	-0.05 10^12*cells per liter	Standard Deviation 0.221
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 6	-0.01 10^12*cells per liter	Standard Deviation 0.18
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 2	-0.03 10^12*cells per liter	Standard Deviation 0.212
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 2	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at follow-up visit	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 1	-0.07 10^12*cells per liter	Standard Deviation 0.232
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 6	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 1	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 4	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 2	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 2	-0.18 10^12*cells per liter	Standard Deviation 0.251
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 1	-0.12 10^12*cells per liter	Standard Deviation 0.264
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 4	-0.16 10^12*cells per liter	Standard Deviation 0.251
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 6	-0.17 10^12*cells per liter	Standard Deviation 0.265
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at follow-up visit	-0.15 10^12*cells per liter	Standard Deviation 0.266
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 1	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 4	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 6	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at follow-up visit	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 4	-0.10 10^12*cells per liter	Standard Deviation 0.233
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 2	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 1	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 6	-0.04 10^12*cells per liter	Standard Deviation 0.238
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at follow-up visit	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at follow-up visit	-0.03 10^12*cells per liter	Standard Deviation 0.254
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 1	-0.04 10^12*cells per liter	Standard Deviation 0.252
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 6	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 4	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 2	-0.10 10^12*cells per liter	Standard Deviation 0.208
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at follow-up visit	-0.0 10^12*cells per liter	Standard Deviation 0.01
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 4	0.01 10^12*cells per liter	Standard Deviation 0.275
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at follow-up visit	0.04 10^12*cells per liter	Standard Deviation 0.3
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 1	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 2	-0.07 10^12*cells per liter	Standard Deviation 0.242
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 2	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 4	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 6	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 1	-0.08 10^12*cells per liter	Standard Deviation 0.254
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 6	-0.02 10^12*cells per liter	Standard Deviation 0.262
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 2	-0.10 10^12*cells per liter	Standard Deviation 0.366
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 2	-0.0 10^12*cells per liter	Standard Deviation 0.02
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at follow-up visit	-0.0 10^12*cells per liter	Standard Deviation 0.02
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 4	-0.0 10^12*cells per liter	Standard Deviation 0.01
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 1	-0.08 10^12*cells per liter	Standard Deviation 0.298
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at follow-up visit	-0.08 10^12*cells per liter	Standard Deviation 0.28
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 6	-0.0 10^12*cells per liter	Standard Deviation 0.01
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 6	-0.10 10^12*cells per liter	Standard Deviation 0.256
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 4	-0.12 10^12*cells per liter	Standard Deviation 0.271
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 1	0.0 10^12*cells per liter	Standard Deviation 0.01
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at follow-up visit	-0.03 10^12*cells per liter	Standard Deviation 0.308
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 6	-0.07 10^12*cells per liter	Standard Deviation 0.303
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 4	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 1	-0.08 10^12*cells per liter	Standard Deviation 0.192
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 2	-0.06 10^12*cells per liter	Standard Deviation 0.229
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at follow-up visit	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 1	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 6	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 4	-0.08 10^12*cells per liter	Standard Deviation 0.248
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 2	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 1	-0.09 10^12*cells per liter	Standard Deviation 0.24
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 2	-0.11 10^12*cells per liter	Standard Deviation 0.232
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 1	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 4	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 6	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at follow-up visit	0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes: change at week 2	-0.0 10^12*cells per liter	Standard Deviation 0.02
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 4	-0.06 10^12*cells per liter	Standard Deviation 0.219
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at week 6	-0.08 10^12*cells per liter	Standard Deviation 0.239
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Erythrocytes: change at follow-up visit	-0.05 10^12*cells per liter	Standard Deviation 0.262

Secondary

Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Time frame: Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 2	-0.11 Percentage of cells	Standard Deviation 1.801
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 1	-0.09 Percentage of cells	Standard Deviation 1.39
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at follow-up visit	-0.04 Percentage of cells	Standard Deviation 0.36
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 1	-0.06 Percentage of cells	Standard Deviation 0.431
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 6	-0.07 Percentage of cells	Standard Deviation 0.272
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 4	-0.07 Percentage of cells	Standard Deviation 0.485
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 2	-0.02 Percentage of cells	Standard Deviation 0.304
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 2	-0.03 Percentage of cells	Standard Deviation 0.382
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 2	-0.12 Percentage of cells	Standard Deviation 7.827
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 1	0.57 Percentage of cells	Standard Deviation 7.515
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at follow-up visit	1.53 Percentage of cells	Standard Deviation 6.219
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 1	0.2 Percentage of cells	Standard Deviation 2.51
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 6	-0.92 Percentage of cells	Standard Deviation 6.701
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 4	1.58 Percentage of cells	Standard Deviation 7.591
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 2	-0.5 Percentage of cells	Standard Deviation 2.19
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at follow-up visit	-1.71 Percentage of cells	Standard Deviation 7.046
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 2	0.20 Percentage of cells	Standard Deviation 6.175
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 1	-0.43 Percentage of cells	Standard Deviation 6.772
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes:change at FU visit	-0.11 Percentage of cells	Standard Deviation 0.396
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 4	0.0 Percentage of cells	Standard Deviation 2.45
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 6	-0.06 Percentage of cells	Standard Deviation 0.382
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at follow-up visit	0.06 Percentage of cells	Standard Deviation 2.105
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 6	-0.6 Percentage of cells	Standard Deviation 2.47
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 6	0.95 Percentage of cells	Standard Deviation 8.648
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 6	0.06 Percentage of cells	Standard Deviation 2.488
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 4	-0.51 Percentage of cells	Standard Deviation 2.509
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 2	0.04 Percentage of cells	Standard Deviation 2.055
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at follow-up (FU) visit	0.3 Percentage of cells	Standard Deviation 2.49
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 1	0.02 Percentage of cells	Standard Deviation 1.913
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at follow-up visit	0.16 Percentage of cells	Standard Deviation 1.754
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes change at week 1	0.03 Percentage of cells	Standard Deviation 0.317
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 4	-1.42 Percentage of cells	Standard Deviation 8.812
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 6	-0.03 Percentage of cells	Standard Deviation 1.522
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 4	0.42 Percentage of cells	Standard Deviation 1.982
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 4	0.16 Percentage of cells	Standard Deviation 0.596
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 1	0.12 Percentage of cells	Standard Deviation 1.391
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 4	-0.8 Percentage of cells	Standard Deviation 1.96
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at follow-up visit	-0.15 Percentage of cells	Standard Deviation 0.476
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 6	-0.58 Percentage of cells	Standard Deviation 7.009
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 6	0.02 Percentage of cells	Standard Deviation 0.361
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 6	0.11 Percentage of cells	Standard Deviation 0.809
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 4	-0.12 Percentage of cells	Standard Deviation 1.725
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 4	0.06 Percentage of cells	Standard Deviation 0.651
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at follow-up visit	-0.22 Percentage of cells	Standard Deviation 1.304
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at follow-up visit	-0.24 Percentage of cells	Standard Deviation 1.86
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 2	0.01 Percentage of cells	Standard Deviation 0.493
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 4	-0.08 Percentage of cells	Standard Deviation 0.359
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 6	0.33 Percentage of cells	Standard Deviation 2.257
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 1	0.17 Percentage of cells	Standard Deviation 1.84
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 1	-0.95 Percentage of cells	Standard Deviation 6.957
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 6	-0.9 Percentage of cells	Standard Deviation 1.93
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at follow-up visit	1.25 Percentage of cells	Standard Deviation 4.974
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 6	0.22 Percentage of cells	Standard Deviation 1.57
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at follow-up visit	-0.65 Percentage of cells	Standard Deviation 6.057
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 1	-0.02 Percentage of cells	Standard Deviation 0.69
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 1	-0.8 Percentage of cells	Standard Deviation 2.11
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 2	0.17 Percentage of cells	Standard Deviation 0.325
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 6	-0.06 Percentage of cells	Standard Deviation 5.461
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 4	-0.17 Percentage of cells	Standard Deviation 1.966
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 4	0.51 Percentage of cells	Standard Deviation 7.297
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes change at week 1	0.14 Percentage of cells	Standard Deviation 0.378
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 2	0.84 Percentage of cells	Standard Deviation 7.544
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 2	-0.31 Percentage of cells	Standard Deviation 1.502
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 2	-0.8 Percentage of cells	Standard Deviation 2.12
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 2	-0.34 Percentage of cells	Standard Deviation 8.219
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 2	-0.20 Percentage of cells	Standard Deviation 1.298
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 1	0.68 Percentage of cells	Standard Deviation 5.814
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at follow-up (FU) visit	-0.7 Percentage of cells	Standard Deviation 2.24
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes:change at FU visit	-0.02 Percentage of cells	Standard Deviation 0.384
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 4	-0.30 Percentage of cells	Standard Deviation 7.754
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 1	2.33 Percentage of cells	Standard Deviation 5.616
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 2	0.09 Percentage of cells	Standard Deviation 0.413
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 4	0.01 Percentage of cells	Standard Deviation 0.46
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 1	-1.3 Percentage of cells	Standard Deviation 2.61
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 2	-1.8 Percentage of cells	Standard Deviation 2.42
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 4	-1.8 Percentage of cells	Standard Deviation 2.06
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 6	-1.6 Percentage of cells	Standard Deviation 2.64
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at follow-up (FU) visit	-1.4 Percentage of cells	Standard Deviation 3.05
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes change at week 1	0.02 Percentage of cells	Standard Deviation 0.483
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 1	-0.06 Percentage of cells	Standard Deviation 0.524
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at follow-up visit	-1.86 Percentage of cells	Standard Deviation 6.892
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 2	-0.09 Percentage of cells	Standard Deviation 0.342
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 4	-0.03 Percentage of cells	Standard Deviation 0.42
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 6	-0.12 Percentage of cells	Standard Deviation 0.48
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at follow-up visit	-0.13 Percentage of cells	Standard Deviation 0.443
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 1	0.17 Percentage of cells	Standard Deviation 0.934
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 2	-0.16 Percentage of cells	Standard Deviation 1.284
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 4	0.15 Percentage of cells	Standard Deviation 1.884
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 6	-0.04 Percentage of cells	Standard Deviation 1.213
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at follow-up visit	-0.09 Percentage of cells	Standard Deviation 1.155
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 1	0.50 Percentage of cells	Standard Deviation 1.428
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 2	0.30 Percentage of cells	Standard Deviation 1.522
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 4	-0.02 Percentage of cells	Standard Deviation 2.072
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 6	-0.00 Percentage of cells	Standard Deviation 1.813
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at follow-up visit	0.50 Percentage of cells	Standard Deviation 1.463
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 6	0.02 Percentage of cells	Standard Deviation 0.473
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes:change at FU visit	0.10 Percentage of cells	Standard Deviation 0.435
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 2	1.68 Percentage of cells	Standard Deviation 5.208
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 4	1.43 Percentage of cells	Standard Deviation 5.298
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 6	0.82 Percentage of cells	Standard Deviation 6.685
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at follow-up visit	1.61 Percentage of cells	Standard Deviation 6.597
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 1	-2.93 Percentage of cells	Standard Deviation 6.191
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 2	-1.70 Percentage of cells	Standard Deviation 6.037
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 4	-1.52 Percentage of cells	Standard Deviation 6.661
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 6	-0.64 Percentage of cells	Standard Deviation 6.833
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 6	-0.24 Percentage of cells	Standard Deviation 1.217
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 6	-0.7 Percentage of cells	Standard Deviation 2.23
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 4	-0.10 Percentage of cells	Standard Deviation 1.582
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 2	-0.13 Percentage of cells	Standard Deviation 1.267
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 4	0.06 Percentage of cells	Standard Deviation 8.536
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 1	-0.06 Percentage of cells	Standard Deviation 1.409
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at follow-up visit	-0.41 Percentage of cells	Standard Deviation 2.188
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 4	0.19 Percentage of cells	Standard Deviation 0.429
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at follow-up (FU) visit	-0.7 Percentage of cells	Standard Deviation 2.39
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 1	-0.37 Percentage of cells	Standard Deviation 1.549
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 6	0.08 Percentage of cells	Standard Deviation 0.458
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 1	0.30 Percentage of cells	Standard Deviation 5.755
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at follow-up visit	-0.85 Percentage of cells	Standard Deviation 6.367
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 6	1.28 Percentage of cells	Standard Deviation 5.881
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at follow-up visit	1.32 Percentage of cells	Standard Deviation 7.355
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 1	0.08 Percentage of cells	Standard Deviation 0.319
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 6	-1.14 Percentage of cells	Standard Deviation 6.872
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 2	0.11 Percentage of cells	Standard Deviation 1.46
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 2	-1.50 Percentage of cells	Standard Deviation 6.578
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 1	-0.4 Percentage of cells	Standard Deviation 2.27
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 4	0.43 Percentage of cells	Standard Deviation 7.586
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 2	1.50 Percentage of cells	Standard Deviation 5.639
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 2	-0.02 Percentage of cells	Standard Deviation 0.473
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 4	0.01 Percentage of cells	Standard Deviation 0.402
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 2	-0.9 Percentage of cells	Standard Deviation 2.32
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 4	-0.37 Percentage of cells	Standard Deviation 1.729
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 2	0.02 Percentage of cells	Standard Deviation 0.323
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 1	0.06 Percentage of cells	Standard Deviation 4.765
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes:change at FU visit	-0.10 Percentage of cells	Standard Deviation 0.398
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 6	0.01 Percentage of cells	Standard Deviation 0.486
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes change at week 1	0.06 Percentage of cells	Standard Deviation 0.364
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 4	-0.8 Percentage of cells	Standard Deviation 2.34
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at follow-up visit	-0.07 Percentage of cells	Standard Deviation 1.226
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 6	0.02 Percentage of cells	Standard Deviation 2.126
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at follow-up visit	0.02 Percentage of cells	Standard Deviation 0.512
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 2	-0.24 Percentage of cells	Standard Deviation 6.146
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at follow-up visit	-0.25 Percentage of cells	Standard Deviation 0.541
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at follow-up visit	-1.32 Percentage of cells	Standard Deviation 6.559
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 1	-0.31 Percentage of cells	Standard Deviation 1.607
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 2	-0.27 Percentage of cells	Standard Deviation 1.131
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes change at week 1	0.11 Percentage of cells	Standard Deviation 0.318
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 4	-0.35 Percentage of cells	Standard Deviation 1.431
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 6	-0.15 Percentage of cells	Standard Deviation 1.714
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at follow-up visit	0.12 Percentage of cells	Standard Deviation 1.954
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at follow-up (FU) visit	-0.2 Percentage of cells	Standard Deviation 2.5
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 1	-0.01 Percentage of cells	Standard Deviation 1.593
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 2	0.38 Percentage of cells	Standard Deviation 1.362
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 6	-0.6 Percentage of cells	Standard Deviation 2.51
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 4	-2.25 Percentage of cells	Standard Deviation 7.468
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 4	0.22 Percentage of cells	Standard Deviation 1.323
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 6	-0.12 Percentage of cells	Standard Deviation 1.03
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at follow-up visit	0.13 Percentage of cells	Standard Deviation 1.205
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 4	0.0 Percentage of cells	Standard Deviation 2.73
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 6	0.15 Percentage of cells	Standard Deviation 0.399
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 2	0.19 Percentage of cells	Standard Deviation 0.443
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes:change at FU visit	-0.03 Percentage of cells	Standard Deviation 0.298
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 2	-0.7 Percentage of cells	Standard Deviation 2.58
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 1	1.31 Percentage of cells	Standard Deviation 6.259
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 2	0.23 Percentage of cells	Standard Deviation 6.175
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 4	2.41 Percentage of cells	Standard Deviation 6.577
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 1	-0.8 Percentage of cells	Standard Deviation 2.41
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 6	1.65 Percentage of cells	Standard Deviation 5.818
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 6	-1.15 Percentage of cells	Standard Deviation 6.969
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at follow-up visit	1.34 Percentage of cells	Standard Deviation 6.165
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 4	0.10 Percentage of cells	Standard Deviation 0.409
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 1	-0.96 Percentage of cells	Standard Deviation 7.843
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 2	-0.03 Percentage of cells	Standard Deviation 0.532
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 4	-0.08 Percentage of cells	Standard Deviation 0.712
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 1	0.03 Percentage of cells	Standard Deviation 0.515
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 6	-0.16 Percentage of cells	Standard Deviation 0.557
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 4	-0.34 Percentage of cells	Standard Deviation 1.258
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 4	-0.05 Percentage of cells	Standard Deviation 0.362
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 1	0.59 Percentage of cells	Standard Deviation 5.179
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 4	1.65 Percentage of cells	Standard Deviation 6.622
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 6	-0.56 Percentage of cells	Standard Deviation 5.699
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 4	0.03 Percentage of cells	Standard Deviation 0.29
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at follow-up visit	0.22 Percentage of cells	Standard Deviation 6.315
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes change at week 1	0.01 Percentage of cells	Standard Deviation 0.32
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at follow-up visit	-0.05 Percentage of cells	Standard Deviation 0.449
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 6	-1.1 Percentage of cells	Standard Deviation 1.98
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 2	0.50 Percentage of cells	Standard Deviation 5.405
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 2	0.11 Percentage of cells	Standard Deviation 1.318
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 6	0.50 Percentage of cells	Standard Deviation 4.452
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at follow-up (FU) visit	-0.6 Percentage of cells	Standard Deviation 2.2
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 1	-0.5 Percentage of cells	Standard Deviation 1.97
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 2	-0.14 Percentage of cells	Standard Deviation 1.199
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 1	-0.19 Percentage of cells	Standard Deviation 1.043
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 1	-0.03 Percentage of cells	Standard Deviation 0.291
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 4	-1.38 Percentage of cells	Standard Deviation 5.415
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 2	-0.49 Percentage of cells	Standard Deviation 6.665
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 2	0.03 Percentage of cells	Standard Deviation 0.355
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 6	-0.15 Percentage of cells	Standard Deviation 0.31
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 6	-0.01 Percentage of cells	Standard Deviation 1.767
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 2	-0.10 Percentage of cells	Standard Deviation 0.318
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at follow-up visit	-0.05 Percentage of cells	Standard Deviation 2.805
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 4	-1.0 Percentage of cells	Standard Deviation 2.34
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 4	0.14 Percentage of cells	Standard Deviation 1.323
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 6	0.13 Percentage of cells	Standard Deviation 0.807
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 1	-0.17 Percentage of cells	Standard Deviation 5.769
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes:change at FU visit	-0.09 Percentage of cells	Standard Deviation 0.331
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at follow-up visit	-0.41 Percentage of cells	Standard Deviation 6.961
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 6	-0.05 Percentage of cells	Standard Deviation 0.296
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 2	-0.9 Percentage of cells	Standard Deviation 2.55
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 1	-0.19 Percentage of cells	Standard Deviation 1.41
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at follow-up visit	0.26 Percentage of cells	Standard Deviation 1.543
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 6	0.13 Percentage of cells	Standard Deviation 6.029
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 2	-0.06 Percentage of cells	Standard Deviation 0.624
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 6	-0.02 Percentage of cells	Standard Deviation 1.324
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 4	-0.9 Percentage of cells	Standard Deviation 2.29
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 4	-1.42 Percentage of cells	Standard Deviation 6.498
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 2	0.06 Percentage of cells	Standard Deviation 0.315
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at follow-up visit	0.15 Percentage of cells	Standard Deviation 1.599
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 1	-0.01 Percentage of cells	Standard Deviation 0.411
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 6	-0.01 Percentage of cells	Standard Deviation 0.355
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 2	-0.7 Percentage of cells	Standard Deviation 2.24
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 6	0.05 Percentage of cells	Standard Deviation 1.229
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 4	0.40 Percentage of cells	Standard Deviation 1.468
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes:change at FU visit	-0.19 Percentage of cells	Standard Deviation 0.395
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes change at week 1	0.04 Percentage of cells	Standard Deviation 0.355
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 1	0.49 Percentage of cells	Standard Deviation 5.509
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 4	-0.01 Percentage of cells	Standard Deviation 0.465
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 2	0.72 Percentage of cells	Standard Deviation 6.638
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 1	-0.9 Percentage of cells	Standard Deviation 2.04
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 2	0.16 Percentage of cells	Standard Deviation 1.304
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 4	1.07 Percentage of cells	Standard Deviation 5.739
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 2	-1.04 Percentage of cells	Standard Deviation 7.376
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 6	-0.04 Percentage of cells	Standard Deviation 5.3
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 4	0.04 Percentage of cells	Standard Deviation 0.446
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at follow-up visit	0.01 Percentage of cells	Standard Deviation 0.472
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 1	0.89 Percentage of cells	Standard Deviation 1.85
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at follow-up visit	0.07 Percentage of cells	Standard Deviation 5.103
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at follow-up visit	-0.71 Percentage of cells	Standard Deviation 6.59
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 1	-1.87 Percentage of cells	Standard Deviation 6.873
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at follow-up visit	0.50 Percentage of cells	Standard Deviation 1.986
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 1	0.51 Percentage of cells	Standard Deviation 1.275
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 6	-1.1 Percentage of cells	Standard Deviation 2.84
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at follow-up (FU) visit	-0.6 Percentage of cells	Standard Deviation 2.73
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 2	0.22 Percentage of cells	Standard Deviation 1.414
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 6	-0.12 Percentage of cells	Standard Deviation 0.576
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 4	-0.03 Percentage of cells	Standard Deviation 1.039
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 4	-0.5 Percentage of cells	Standard Deviation 2.56
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at follow-up visit	2.48 Percentage of cells	Standard Deviation 6.914
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 2	-0.56 Percentage of cells	Standard Deviation 8.017
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 2	-0.01 Percentage of cells	Standard Deviation 1.755
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 1	1.79 Percentage of cells	Standard Deviation 6.269
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 6	-0.17 Percentage of cells	Standard Deviation 0.75
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes:change at FU visit	0.11 Percentage of cells	Standard Deviation 0.448
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at follow-up visit	-0.25 Percentage of cells	Standard Deviation 0.572
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at follow-up visit	-0.04 Percentage of cells	Standard Deviation 1.047
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 2	-0.24 Percentage of cells	Standard Deviation 0.709
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at follow-up visit	-0.13 Percentage of cells	Standard Deviation 2.021
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 1	-1.44 Percentage of cells	Standard Deviation 6.58
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 2	-1.0 Percentage of cells	Standard Deviation 2.61
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 6	-1.01 Percentage of cells	Standard Deviation 8.445
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 6	0.01 Percentage of cells	Standard Deviation 0.463
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 4	-0.37 Percentage of cells	Standard Deviation 1.747
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at week 4	-0.45 Percentage of cells	Standard Deviation 7.362
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 4	0.33 Percentage of cells	Standard Deviation 1.695
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes: change at week 1	-0.11 Percentage of cells	Standard Deviation 1.251
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 6	-0.8 Percentage of cells	Standard Deviation 2.6
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 4	0.56 Percentage of cells	Standard Deviation 7.264
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 4	-0.10 Percentage of cells	Standard Deviation 0.464
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes change at week 1	0.01 Percentage of cells	Standard Deviation 0.329
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 6	-0.19 Percentage of cells	Standard Deviation 1.84
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 1	-0.23 Percentage of cells	Standard Deviation 1.339
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils/Leukocytes: change at follow-up visit	-2.04 Percentage of cells	Standard Deviation 7.7
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 2	0.86 Percentage of cells	Standard Deviation 7.264
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at follow-up (FU) visit	-0.3 Percentage of cells	Standard Deviation 2.78
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes/Leukocytes: change at week 6	1.52 Percentage of cells	Standard Deviation 7.266
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 4	0.05 Percentage of cells	Standard Deviation 0.374
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes/Leukocytes : change at week 6	-0.16 Percentage of cells	Standard Deviation 1.516
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Reticulocytes/Erythrocytes: change at week 2	-0.01 Percentage of cells	Standard Deviation 0.389
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils/Leukocytes: change at week 1	-0.01 Percentage of cells	Standard Deviation 0.57
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils/Leukocytes: change at week 2	-0.05 Percentage of cells	Standard Deviation 1.531
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Hematocrit: change at week 1	-0.9 Percentage of cells	Standard Deviation 2.3

Secondary

Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Time frame: Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-0.01 Gram per deciliter	Standard Deviation 0.79
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	0.05 Gram per deciliter	Standard Deviation 0.613
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-0.13 Gram per deciliter	Standard Deviation 0.832
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-0.16 Gram per deciliter	Standard Deviation 0.636
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	0.03 Gram per deciliter	Standard Deviation 0.725
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-0.04 Gram per deciliter	Standard Deviation 0.717
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-0.17 Gram per deciliter	Standard Deviation 0.63
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-0.22 Gram per deciliter	Standard Deviation 0.62
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-0.06 Gram per deciliter	Standard Deviation 0.614
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-0.09 Gram per deciliter	Standard Deviation 0.566
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-0.64 Gram per deciliter	Standard Deviation 0.715
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-0.48 Gram per deciliter	Standard Deviation 0.767
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-0.36 Gram per deciliter	Standard Deviation 0.775
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-0.49 Gram per deciliter	Standard Deviation 0.777
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-0.48 Gram per deciliter	Standard Deviation 0.659
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-0.25 Gram per deciliter	Standard Deviation 0.628
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-0.09 Gram per deciliter	Standard Deviation 0.784
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-0.24 Gram per deciliter	Standard Deviation 0.657
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-0.03 Gram per deciliter	Standard Deviation 0.617
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-0.12 Gram per deciliter	Standard Deviation 0.678
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-0.06 Gram per deciliter	Standard Deviation 0.821
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-0.26 Gram per deciliter	Standard Deviation 0.726
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-0.22 Gram per deciliter	Standard Deviation 0.798
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-0.11 Gram per deciliter	Standard Deviation 0.775
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	0.00 Gram per deciliter	Standard Deviation 0.773
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-0.27 Gram per deciliter	Standard Deviation 0.789
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-0.22 Gram per deciliter	Standard Deviation 0.724
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-0.16 Gram per deciliter	Standard Deviation 0.83
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-0.19 Gram per deciliter	Standard Deviation 0.698
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-0.27 Gram per deciliter	Standard Deviation 0.756
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-0.32 Gram per deciliter	Standard Deviation 0.701
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-0.21 Gram per deciliter	Standard Deviation 0.584
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-0.25 Gram per deciliter	Standard Deviation 0.625
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-0.12 Gram per deciliter	Standard Deviation 0.826
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-0.21 Gram per deciliter	Standard Deviation 0.833
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at follow-up visit	-0.18 Gram per deciliter	Standard Deviation 0.74
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 6	-0.28 Gram per deciliter	Standard Deviation 0.683
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 1	-0.27 Gram per deciliter	Standard Deviation 0.679
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 4	-0.20 Gram per deciliter	Standard Deviation 0.658
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Change at week 2	-0.32 Gram per deciliter	Standard Deviation 0.793

Secondary

Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Time frame: Baseline, Weeks 1, 2, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 6	0.033 10^9 *cells per liter	Standard Deviation 0.3375
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at follow-up visit	-0.066 10^9 *cells per liter	Standard Deviation 1.5744
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 2	-0.119 10^9 *cells per liter	Standard Deviation 1.5672
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 2	-0.019 10^9 *cells per liter	Standard Deviation 0.1087
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 6	0.112 10^9 *cells per liter	Standard Deviation 1.6282
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 6	0.002 10^9 *cells per liter	Standard Deviation 0.0935
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at follow-up visit	0.011 10^9 *cells per liter	Standard Deviation 0.1806
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 1	-0.008 10^9 *cells per liter	Standard Deviation 0.5539
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 4	0.107 10^9 *cells per liter	Standard Deviation 0.4302
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 1	-0.006 10^9 *cells per liter	Standard Deviation 0.0319
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 4	0.032 10^9 *cells per liter	Standard Deviation 0.1813
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 2	-0.061 10^9 *cells per liter	Standard Deviation 0.5558
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 6	0.017 10^9 *cells per liter	Standard Deviation 0.1777
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 6	4.9 10^9 *cells per liter	Standard Deviation 35.17
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 4	10.5 10^9 *cells per liter	Standard Deviation 36.42
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 4	-0.035 10^9 *cells per liter	Standard Deviation 0.1904
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at follow-up visit	1.3 10^9 *cells per liter	Standard Deviation 30.48
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 4	-0.304 10^9 *cells per liter	Standard Deviation 1.6117
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 1	0.027 10^9 *cells per liter	Standard Deviation 1.6137
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at follow-up visit	-0.004 10^9 *cells per liter	Standard Deviation 0.0265
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 6	-0.005 10^9 *cells per liter	Standard Deviation 0.0186
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 1	0.027 10^9 *cells per liter	Standard Deviation 1.874
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 4	-0.006 10^9 *cells per liter	Standard Deviation 0.0328
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 2	-0.006 10^9 *cells per liter	Standard Deviation 0.1509
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 1	0.9 10^9 *cells per liter	Standard Deviation 60.03
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 2	-0.206 10^9 *cells per liter	Standard Deviation 1.8886
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 2	-0.002 10^9 *cells per liter	Standard Deviation 0.0179
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at follow-up visit	0.134 10^9 *cells per liter	Standard Deviation 0.3256
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at follow-up visit	-0.229 10^9 *cells per liter	Standard Deviation 1.3379
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 1	0.006 10^9 *cells per liter	Standard Deviation 0.1796
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 4	-0.203 10^9 *cells per liter	Standard Deviation 1.739
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 1	0.007 10^9 *cells per liter	Standard Deviation 0.0964
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 2	-4.9 10^9 *cells per liter	Standard Deviation 58.16
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 6	0.160 10^9 *cells per liter	Standard Deviation 1.7059
Vehicle Cream Once Daily (QD)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at follow-up visit	0.022 10^9 *cells per liter	Standard Deviation 0.1461
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 1	0.205 10^9 *cells per liter	Standard Deviation 0.9185
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 2	0.293 10^9 *cells per liter	Standard Deviation 1.5459
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at follow-up visit	0.006 10^9 *cells per liter	Standard Deviation 0.0931
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at follow-up visit	0.479 10^9 *cells per liter	Standard Deviation 1.0939
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 1	0.030 10^9 *cells per liter	Standard Deviation 0.0855
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 2	7.1 10^9 *cells per liter	Standard Deviation 43.34
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 2	0.016 10^9 *cells per liter	Standard Deviation 0.1343
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 6	0.029 10^9 *cells per liter	Standard Deviation 0.109
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 6	0.066 10^9 *cells per liter	Standard Deviation 1.0672
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 1	0.395 10^9 *cells per liter	Standard Deviation 1.094
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 4	0.729 10^9 *cells per liter	Standard Deviation 1.3199
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 1	0.124 10^9 *cells per liter	Standard Deviation 0.3659
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 1	0.004 10^9 *cells per liter	Standard Deviation 0.0445
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 4	0.229 10^9 *cells per liter	Standard Deviation 0.3998
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at follow-up visit	-0.003 10^9 *cells per liter	Standard Deviation 0.0259
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 2	0.004 10^9 *cells per liter	Standard Deviation 0.0261
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 4	0.018 10^9 *cells per liter	Standard Deviation 0.112
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at follow-up visit	0.261 10^9 *cells per liter	Standard Deviation 0.8874
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 4	10.1 10^9 *cells per liter	Standard Deviation 37.55
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 2	0.145 10^9 *cells per liter	Standard Deviation 0.3735
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 6	0.017 10^9 *cells per liter	Standard Deviation 0.1069
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 2	-0.000 10^9 *cells per liter	Standard Deviation 0.0734
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at follow-up visit	0.194 10^9 *cells per liter	Standard Deviation 0.3533
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 6	0.009 10^9 *cells per liter	Standard Deviation 0.0489
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 6	0.016 10^9 *cells per liter	Standard Deviation 0.3437
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 6	-3.3 10^9 *cells per liter	Standard Deviation 32.76
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 6	-0.001 10^9 *cells per liter	Standard Deviation 0.8996
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 2	0.459 10^9 *cells per liter	Standard Deviation 1.5567
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 1	6.8 10^9 *cells per liter	Standard Deviation 34.08
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 4	0.011 10^9 *cells per liter	Standard Deviation 0.0404
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 4	0.030 10^9 *cells per liter	Standard Deviation 0.1212
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 1	0.036 10^9 *cells per liter	Standard Deviation 0.0963
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 4	0.441 10^9 *cells per liter	Standard Deviation 1.2814
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at follow-up visit	16.3 10^9 *cells per liter	Standard Deviation 37.13
PF-06700841 0.1% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at follow-up visit	0.021 10^9 *cells per liter	Standard Deviation 0.0824
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 1	-0.177 10^9 *cells per liter	Standard Deviation 1.0805
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 6	-0.362 10^9 *cells per liter	Standard Deviation 1.3154
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 2	-0.009 10^9 *cells per liter	Standard Deviation 0.0276
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at follow-up visit	-0.114 10^9 *cells per liter	Standard Deviation 1.4545
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 1	-0.007 10^9 *cells per liter	Standard Deviation 0.0349
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 6	-6.6 10^9 *cells per liter	Standard Deviation 41.66
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 4	0.013 10^9 *cells per liter	Standard Deviation 0.1234
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at follow-up visit	-8.5 10^9 *cells per liter	Standard Deviation 30.15
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 2	-0.003 10^9 *cells per liter	Standard Deviation 0.0724
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 1	-0.051 10^9 *cells per liter	Standard Deviation 1.2403
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at follow-up visit	0.030 10^9 *cells per liter	Standard Deviation 0.1467
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 2	-0.288 10^9 *cells per liter	Standard Deviation 1.6842
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 1	0.030 10^9 *cells per liter	Standard Deviation 0.0987
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 4	0.189 10^9 *cells per liter	Standard Deviation 1.3534
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at follow-up visit	-0.023 10^9 *cells per liter	Standard Deviation 0.1196
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 6	-0.505 10^9 *cells per liter	Standard Deviation 1.6474
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 6	-0.025 10^9 *cells per liter	Standard Deviation 0.1351
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at follow-up visit	-0.048 10^9 *cells per liter	Standard Deviation 2.0206
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 2	-8.1 10^9 *cells per liter	Standard Deviation 41.92
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 1	0.107 10^9 *cells per liter	Standard Deviation 0.313
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 4	0.008 10^9 *cells per liter	Standard Deviation 0.1325
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 2	0.010 10^9 *cells per liter	Standard Deviation 0.4115
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 1	-3.3 10^9 *cells per liter	Standard Deviation 32.39
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 2	-0.023 10^9 *cells per liter	Standard Deviation 0.0809
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 4	0.135 10^9 *cells per liter	Standard Deviation 0.44
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 1	-0.004 10^9 *cells per liter	Standard Deviation 0.1092
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 6	-0.079 10^9 *cells per liter	Standard Deviation 0.4826
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at follow-up visit	0.065 10^9 *cells per liter	Standard Deviation 0.6042
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 6	-0.025 10^9 *cells per liter	Standard Deviation 0.1191
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at follow-up visit	-0.007 10^9 *cells per liter	Standard Deviation 0.0321
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 4	-2.4 10^9 *cells per liter	Standard Deviation 37.68
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 6	-0.012 10^9 *cells per liter	Standard Deviation 0.0313
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 2	-0.261 10^9 *cells per liter	Standard Deviation 1.3969
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 4	-0.002 10^9 *cells per liter	Standard Deviation 0.03
PF-06700841 0.3% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 4	0.036 10^9 *cells per liter	Standard Deviation 1.1595
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 6	0.237 10^9 *cells per liter	Standard Deviation 1.4501
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 2	-0.136 10^9 *cells per liter	Standard Deviation 1.0669
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 6	0.104 10^9 *cells per liter	Standard Deviation 0.4337
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 6	-0.005 10^9 *cells per liter	Standard Deviation 0.1021
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at follow-up visit	-0.004 10^9 *cells per liter	Standard Deviation 0.181
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 4	0.085 10^9 *cells per liter	Standard Deviation 1.3541
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at follow-up visit	0.007 10^9 *cells per liter	Standard Deviation 0.0407
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 2	-0.094 10^9 *cells per liter	Standard Deviation 1.2877
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 1	0.009 10^9 *cells per liter	Standard Deviation 0.0879
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at follow-up visit	0.343 10^9 *cells per liter	Standard Deviation 1.3049
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at follow-up visit	-0.022 10^9 *cells per liter	Standard Deviation 0.4419
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 4	-0.3 10^9 *cells per liter	Standard Deviation 36.27
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 4	0.001 10^9 *cells per liter	Standard Deviation 0.0256
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 1	0.407 10^9 *cells per liter	Standard Deviation 1.2225
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 2	-0.014 10^9 *cells per liter	Standard Deviation 0.1055
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at follow-up visit	0.005 10^9 *cells per liter	Standard Deviation 0.0887
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at follow-up visit	0.1 10^9 *cells per liter	Standard Deviation 32.36
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 4	0.096 10^9 *cells per liter	Standard Deviation 1.3199
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 1	0.319 10^9 *cells per liter	Standard Deviation 1.0276
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 6	-2.3 10^9 *cells per liter	Standard Deviation 32.7
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 6	0.008 10^9 *cells per liter	Standard Deviation 0.0344
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 6	0.112 10^9 *cells per liter	Standard Deviation 1.224
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 4	-0.003 10^9 *cells per liter	Standard Deviation 0.1092
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 2	0.009 10^9 *cells per liter	Standard Deviation 0.098
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 1	0.010 10^9 *cells per liter	Standard Deviation 0.0258
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 2	0.044 10^9 *cells per liter	Standard Deviation 0.4225
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 2	-0.1 10^9 *cells per liter	Standard Deviation 32.45
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 1	0.081 10^9 *cells per liter	Standard Deviation 0.3839
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 1	1.0 10^9 *cells per liter	Standard Deviation 25.76
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 4	0.012 10^9 *cells per liter	Standard Deviation 0.4596
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 4	-0.019 10^9 *cells per liter	Standard Deviation 0.1102
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at follow-up visit	0.329 10^9 *cells per liter	Standard Deviation 1.3938
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 1	-0.011 10^9 *cells per liter	Standard Deviation 0.093
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 2	0.001 10^9 *cells per liter	Standard Deviation 0.0197
PF-06700841 1.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 6	0.018 10^9 *cells per liter	Standard Deviation 0.1387
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 1	0.019 10^9 *cells per liter	Standard Deviation 0.1055
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 1	8.5 10^9 *cells per liter	Standard Deviation 41.61
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 2	5.0 10^9 *cells per liter	Standard Deviation 31.39
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 4	-5.9 10^9 *cells per liter	Standard Deviation 37.47
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 6	-5.2 10^9 *cells per liter	Standard Deviation 38.53
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at follow-up visit	10.2 10^9 *cells per liter	Standard Deviation 47.3
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 1	0.259 10^9 *cells per liter	Standard Deviation 1.129
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 2	-0.116 10^9 *cells per liter	Standard Deviation 1.0364
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 4	-0.074 10^9 *cells per liter	Standard Deviation 1.0641
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 6	-0.244 10^9 *cells per liter	Standard Deviation 1.2763
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at follow-up visit	0.123 10^9 *cells per liter	Standard Deviation 0.8496
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 1	0.186 10^9 *cells per liter	Standard Deviation 0.384
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 2	0.012 10^9 *cells per liter	Standard Deviation 0.4251
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 4	0.139 10^9 *cells per liter	Standard Deviation 0.3977
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 6	0.068 10^9 *cells per liter	Standard Deviation 0.3168
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at follow-up visit	0.130 10^9 *cells per liter	Standard Deviation 0.4277
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 1	0.069 10^9 *cells per liter	Standard Deviation 1.0706
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 2	-0.109 10^9 *cells per liter	Standard Deviation 0.9653
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 4	-0.190 10^9 *cells per liter	Standard Deviation 1.0404
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 6	-0.250 10^9 *cells per liter	Standard Deviation 1.172
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at follow-up visit	-0.020 10^9 *cells per liter	Standard Deviation 0.7731
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 1	0.003 10^9 *cells per liter	Standard Deviation 0.0361
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 2	-0.005 10^9 *cells per liter	Standard Deviation 0.0394
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 4	-0.007 10^9 *cells per liter	Standard Deviation 0.0495
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 6	-0.015 10^9 *cells per liter	Standard Deviation 0.0415
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at follow-up visit	-0.015 10^9 *cells per liter	Standard Deviation 0.0426
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 1	-0.014 10^9 *cells per liter	Standard Deviation 0.1216
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 2	-0.029 10^9 *cells per liter	Standard Deviation 0.0915
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 4	-0.032 10^9 *cells per liter	Standard Deviation 0.104
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 6	-0.027 10^9 *cells per liter	Standard Deviation 0.1125
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at follow-up visit	0.008 10^9 *cells per liter	Standard Deviation 0.127
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 2	0.017 10^9 *cells per liter	Standard Deviation 0.0865
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 4	0.009 10^9 *cells per liter	Standard Deviation 0.0986
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 6	-0.019 10^9 *cells per liter	Standard Deviation 0.0726
PF-06700841 3.0% Cream QD	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at follow-up visit	0.021 10^9 *cells per liter	Standard Deviation 0.0739
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 6	0.004 10^9 *cells per liter	Standard Deviation 0.0847
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 2	-0.003 10^9 *cells per liter	Standard Deviation 0.3165
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 2	-4.9 10^9 *cells per liter	Standard Deviation 31.84
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 2	-0.006 10^9 *cells per liter	Standard Deviation 0.0621
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 6	-0.004 10^9 *cells per liter	Standard Deviation 0.0188
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 1	0.006 10^9 *cells per liter	Standard Deviation 0.0877
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 2	-0.007 10^9 *cells per liter	Standard Deviation 1.2637
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 4	-0.001 10^9 *cells per liter	Standard Deviation 0.0255
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 1	0.051 10^9 *cells per liter	Standard Deviation 0.3557
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at follow-up visit	-0.008 10^9 *cells per liter	Standard Deviation 0.2483
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 1	6.6 10^9 *cells per liter	Standard Deviation 33.4
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 4	-0.012 10^9 *cells per liter	Standard Deviation 0.0832
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at follow-up visit	-0.093 10^9 *cells per liter	Standard Deviation 1.234
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 4	0.398 10^9 *cells per liter	Standard Deviation 1.5999
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 4	4.4 10^9 *cells per liter	Standard Deviation 37.79
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at follow-up visit	-0.117 10^9 *cells per liter	Standard Deviation 1.4856
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 6	-0.269 10^9 *cells per liter	Standard Deviation 1.0761
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 4	0.338 10^9 *cells per liter	Standard Deviation 1.3577
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at follow-up visit	-0.035 10^9 *cells per liter	Standard Deviation 0.4054
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 6	-0.007 10^9 *cells per liter	Standard Deviation 0.1025
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 4	0.035 10^9 *cells per liter	Standard Deviation 0.0978
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 6	-0.228 10^9 *cells per liter	Standard Deviation 0.9681
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at follow-up visit	-0.005 10^9 *cells per liter	Standard Deviation 0.0269
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 2	-0.015 10^9 *cells per liter	Standard Deviation 1.1305
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at follow-up visit	0.018 10^9 *cells per liter	Standard Deviation 0.1047
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 1	0.001 10^9 *cells per liter	Standard Deviation 0.0191
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 6	-0.033 10^9 *cells per liter	Standard Deviation 0.3092
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 6	0.2 10^9 *cells per liter	Standard Deviation 37.28
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 2	0.003 10^9 *cells per liter	Standard Deviation 0.0244
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 2	0.013 10^9 *cells per liter	Standard Deviation 0.0983
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 1	-0.008 10^9 *cells per liter	Standard Deviation 0.1148
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 1	0.017 10^9 *cells per liter	Standard Deviation 1.1291
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at follow-up visit	-5.2 10^9 *cells per liter	Standard Deviation 40.7
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 4	0.039 10^9 *cells per liter	Standard Deviation 0.4169
Vehicle Cream Twice Daily (BID)	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 1	0.068 10^9 *cells per liter	Standard Deviation 1.2929
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 2	-0.003 10^9 *cells per liter	Standard Deviation 0.0433
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 4	-0.005 10^9 *cells per liter	Standard Deviation 0.9958
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 2	0.288 10^9 *cells per liter	Standard Deviation 1.7822
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at follow-up visit	0.029 10^9 *cells per liter	Standard Deviation 0.1788
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 4	-0.001 10^9 *cells per liter	Standard Deviation 0.0337
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 1	0.030 10^9 *cells per liter	Standard Deviation 1.3015
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 6	-0.009 10^9 *cells per liter	Standard Deviation 0.0373
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at follow-up visit	0.050 10^9 *cells per liter	Standard Deviation 0.4699
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 6	0.003 10^9 *cells per liter	Standard Deviation 0.1097
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at follow-up visit	0.001 10^9 *cells per liter	Standard Deviation 0.0295
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 6	0.027 10^9 *cells per liter	Standard Deviation 0.2455
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 4	0.127 10^9 *cells per liter	Standard Deviation 0.263
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 1	0.068 10^9 *cells per liter	Standard Deviation 0.0959
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 2	0.070 10^9 *cells per liter	Standard Deviation 0.4603
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 2	0.022 10^9 *cells per liter	Standard Deviation 0.0762
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 1	0.089 10^9 *cells per liter	Standard Deviation 0.432
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 4	0.042 10^9 *cells per liter	Standard Deviation 0.1076
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at follow-up visit	0.210 10^9 *cells per liter	Standard Deviation 1.7456
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 6	-0.048 10^9 *cells per liter	Standard Deviation 1.3823
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 1	-2.1 10^9 *cells per liter	Standard Deviation 31.94
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 6	-0.001 10^9 *cells per liter	Standard Deviation 0.0812
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 4	0.168 10^9 *cells per liter	Standard Deviation 1.0902
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at follow-up visit	0.048 10^9 *cells per liter	Standard Deviation 0.152
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 2	0.422 10^9 *cells per liter	Standard Deviation 1.8986
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 1	0.238 10^9 *cells per liter	Standard Deviation 1.4993
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 1	0.051 10^9 *cells per liter	Standard Deviation 0.1244
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at follow-up visit	5.8 10^9 *cells per liter	Standard Deviation 48.55
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 2	0.049 10^9 *cells per liter	Standard Deviation 0.1471
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 6	-1.8 10^9 *cells per liter	Standard Deviation 37.05
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 4	0.007 10^9 *cells per liter	Standard Deviation 0.1008
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 4	0.7 10^9 *cells per liter	Standard Deviation 36.51
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at follow-up visit	0.088 10^9 *cells per liter	Standard Deviation 1.4614
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 1	0.002 10^9 *cells per liter	Standard Deviation 0.0299
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 6	-0.064 10^9 *cells per liter	Standard Deviation 1.2422
PF-06700841 0.3% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 2	7.5 10^9 *cells per liter	Standard Deviation 37.94
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 2	0.005 10^9 *cells per liter	Standard Deviation 0.1256
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 1	-0.251 10^9 *cells per liter	Standard Deviation 2.2421
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 1	0.011 10^9 *cells per liter	Standard Deviation 0.1195
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 2	0.169 10^9 *cells per liter	Standard Deviation 0.5319
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at follow-up visit	2.5 10^9 *cells per liter	Standard Deviation 58.75
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 2	-0.012 10^9 *cells per liter	Standard Deviation 0.0428
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 1	-0.006 10^9 *cells per liter	Standard Deviation 0.1165
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at follow-up visit	-0.006 10^9 *cells per liter	Standard Deviation 0.1282
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 6	-0.012 10^9 *cells per liter	Standard Deviation 0.12
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 1	0.002 10^9 *cells per liter	Standard Deviation 0.0343
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 2	0.025 10^9 *cells per liter	Standard Deviation 0.1496
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 6	8.6 10^9 *cells per liter	Standard Deviation 47.85
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 6	-0.376 10^9 *cells per liter	Standard Deviation 2.1125
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 4	0.176 10^9 *cells per liter	Standard Deviation 0.6274
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 4	11.0 10^9 *cells per liter	Standard Deviation 46.26
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at follow-up visit	-0.019 10^9 *cells per liter	Standard Deviation 0.0361
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 6	0.079 10^9 *cells per liter	Standard Deviation 0.3846
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 2	-0.190 10^9 *cells per liter	Standard Deviation 2.0749
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Monocytes: change at week 4	0.038 10^9 *cells per liter	Standard Deviation 0.1331
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 4	-0.004 10^9 *cells per liter	Standard Deviation 0.0323
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at follow-up visit	0.195 10^9 *cells per liter	Standard Deviation 0.4663
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 6	-0.022 10^9 *cells per liter	Standard Deviation 0.1415
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 6	-0.347 10^9 *cells per liter	Standard Deviation 2.1442
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 4	0.041 10^9 *cells per liter	Standard Deviation 2.1647
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at follow-up visit	-0.562 10^9 *cells per liter	Standard Deviation 2.3227
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at week 4	-0.012 10^9 *cells per liter	Standard Deviation 0.1499
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 1	12.6 10^9 *cells per liter	Standard Deviation 44.08
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at follow-up visit	-0.404 10^9 *cells per liter	Standard Deviation 2.4817
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Neutrophils: change at week 4	-0.158 10^9 *cells per liter	Standard Deviation 2.0005
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Eosinophils: change at follow-up visit	-0.011 10^9 *cells per liter	Standard Deviation 0.1945
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 2	-0.006 10^9 *cells per liter	Standard Deviation 2.3428
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Basophils: change at week 6	-0.015 10^9 *cells per liter	Standard Deviation 0.0383
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Lymphocytes: change at week 1	0.223 10^9 *cells per liter	Standard Deviation 0.3849
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Leukocytes: change at week 1	-0.025 10^9 *cells per liter	Standard Deviation 2.3529
PF-06700841 1.0% Cream BID	Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit	Platelets: change at week 2	14.8 10^9 *cells per liter	Standard Deviation 50.99

Secondary

Change From Baseline in Lipids Profile Values at Week 6

Lipid parameters that were assessed: high density lipoprotein (HDL) cholesterol, triglycerides, cholesterol, low density lipoprotein (LDL) cholesterol.

Time frame: Baseline, Week 6

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Lipids Profile Values at Week 6	Cholesterol	-3.5 Microgram per deciliter	Standard Deviation 16.39
Vehicle Cream Once Daily (QD)	Change From Baseline in Lipids Profile Values at Week 6	LDL Cholesterol	-3.4 Microgram per deciliter	Standard Deviation 14.45
Vehicle Cream Once Daily (QD)	Change From Baseline in Lipids Profile Values at Week 6	Triglycerides	3.3 Microgram per deciliter	Standard Deviation 38.84
Vehicle Cream Once Daily (QD)	Change From Baseline in Lipids Profile Values at Week 6	HDL cholesterol	-2.8 Microgram per deciliter	Standard Deviation 6.65
PF-06700841 0.1% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	Cholesterol	-5.6 Microgram per deciliter	Standard Deviation 27.59
PF-06700841 0.1% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	HDL cholesterol	0.1 Microgram per deciliter	Standard Deviation 5.34
PF-06700841 0.1% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	LDL Cholesterol	-6.3 Microgram per deciliter	Standard Deviation 25.28
PF-06700841 0.1% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	Triglycerides	-4.2 Microgram per deciliter	Standard Deviation 59.3
PF-06700841 0.3% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	Cholesterol	-12.8 Microgram per deciliter	Standard Deviation 20.53
PF-06700841 0.3% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	Triglycerides	-6.5 Microgram per deciliter	Standard Deviation 37.3
PF-06700841 0.3% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	LDL Cholesterol	-12.1 Microgram per deciliter	Standard Deviation 16.44
PF-06700841 0.3% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	HDL cholesterol	-1.3 Microgram per deciliter	Standard Deviation 7.74
PF-06700841 1.0% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	Triglycerides	1.8 Microgram per deciliter	Standard Deviation 60.74
PF-06700841 1.0% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	HDL cholesterol	2.7 Microgram per deciliter	Standard Deviation 8.33
PF-06700841 1.0% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	LDL Cholesterol	2.1 Microgram per deciliter	Standard Deviation 20.13
PF-06700841 1.0% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	Cholesterol	6.8 Microgram per deciliter	Standard Deviation 24.09
PF-06700841 3.0% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	Triglycerides	-18.9 Microgram per deciliter	Standard Deviation 56.78
PF-06700841 3.0% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	HDL cholesterol	1.9 Microgram per deciliter	Standard Deviation 11.18
PF-06700841 3.0% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	LDL Cholesterol	-11.0 Microgram per deciliter	Standard Deviation 29.06
PF-06700841 3.0% Cream QD	Change From Baseline in Lipids Profile Values at Week 6	Cholesterol	-10.4 Microgram per deciliter	Standard Deviation 30.79
Vehicle Cream Twice Daily (BID)	Change From Baseline in Lipids Profile Values at Week 6	LDL Cholesterol	-0.8 Microgram per deciliter	Standard Deviation 14.48
Vehicle Cream Twice Daily (BID)	Change From Baseline in Lipids Profile Values at Week 6	Cholesterol	-0.2 Microgram per deciliter	Standard Deviation 18.7
Vehicle Cream Twice Daily (BID)	Change From Baseline in Lipids Profile Values at Week 6	HDL cholesterol	0.0 Microgram per deciliter	Standard Deviation 6.76
Vehicle Cream Twice Daily (BID)	Change From Baseline in Lipids Profile Values at Week 6	Triglycerides	-8.1 Microgram per deciliter	Standard Deviation 50.41
PF-06700841 0.3% Cream BID	Change From Baseline in Lipids Profile Values at Week 6	Triglycerides	-7.0 Microgram per deciliter	Standard Deviation 58.36
PF-06700841 0.3% Cream BID	Change From Baseline in Lipids Profile Values at Week 6	HDL cholesterol	1.2 Microgram per deciliter	Standard Deviation 4.12
PF-06700841 0.3% Cream BID	Change From Baseline in Lipids Profile Values at Week 6	Cholesterol	5.3 Microgram per deciliter	Standard Deviation 30.58
PF-06700841 0.3% Cream BID	Change From Baseline in Lipids Profile Values at Week 6	LDL Cholesterol	4.4 Microgram per deciliter	Standard Deviation 23.55
PF-06700841 1.0% Cream BID	Change From Baseline in Lipids Profile Values at Week 6	HDL cholesterol	0.3 Microgram per deciliter	Standard Deviation 8.56
PF-06700841 1.0% Cream BID	Change From Baseline in Lipids Profile Values at Week 6	LDL Cholesterol	-1.1 Microgram per deciliter	Standard Deviation 16.29
PF-06700841 1.0% Cream BID	Change From Baseline in Lipids Profile Values at Week 6	Triglycerides	-4.4 Microgram per deciliter	Standard Deviation 55.66
PF-06700841 1.0% Cream BID	Change From Baseline in Lipids Profile Values at Week 6	Cholesterol	-0.9 Microgram per deciliter	Standard Deviation 19.86

Secondary

Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6

Time frame: Baseline, Weeks 2 and 6

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 2	-1.4 Milliseconds	Standard Deviation 8.02
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 6	-4.1 Milliseconds	Standard Deviation 14.61
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: baseline	161.9 Milliseconds	Standard Deviation 23.3
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: baseline	92.5 Milliseconds	Standard Deviation 9.36
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: baseline	407.7 Milliseconds	Standard Deviation 17.78
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 6	-0.9 Milliseconds	Standard Deviation 10.16
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: baseline	395.2 Milliseconds	Standard Deviation 31.53
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 6	-4.9 Milliseconds	Standard Deviation 19.54
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 6	-1.9 Milliseconds	Standard Deviation 6.55
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 2	0.8 Milliseconds	Standard Deviation 14.41
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 2	-5.7 Milliseconds	Standard Deviation 11.86
Vehicle Cream Once Daily (QD)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 2	-5.9 Milliseconds	Standard Deviation 23.16
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: baseline	397.9 Milliseconds	Standard Deviation 15.98
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: baseline	91.5 Milliseconds	Standard Deviation 9.71
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 2	-0.4 Milliseconds	Standard Deviation 5.34
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 6	1.3 Milliseconds	Standard Deviation 18.11
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: baseline	385.3 Milliseconds	Standard Deviation 23.64
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 2	-0.9 Milliseconds	Standard Deviation 15.92
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 6	-0.5 Milliseconds	Standard Deviation 14.93
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 6	1.4 Milliseconds	Standard Deviation 5.62
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 6	-0.1 Milliseconds	Standard Deviation 13.81
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 2	-1.5 Milliseconds	Standard Deviation 13.7
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: baseline	160.2 Milliseconds	Standard Deviation 24.01
PF-06700841 0.1% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 2	-1.3 Milliseconds	Standard Deviation 17.73
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: baseline	388.8 Milliseconds	Standard Deviation 33.66
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: baseline	403.8 Milliseconds	Standard Deviation 22.43
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 6	0.9 Milliseconds	Standard Deviation 16.11
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 2	-3.9 Milliseconds	Standard Deviation 15.6
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 2	0.7 Milliseconds	Standard Deviation 18.54
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 2	-1.1 Milliseconds	Standard Deviation 19.31
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 6	2.8 Milliseconds	Standard Deviation 19.66
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: baseline	91.1 Milliseconds	Standard Deviation 9.29
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: baseline	161.4 Milliseconds	Standard Deviation 27.59
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 2	-1.3 Milliseconds	Standard Deviation 3.46
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 6	-1.9 Milliseconds	Standard Deviation 14.37
PF-06700841 0.3% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 6	-0.5 Milliseconds	Standard Deviation 4.76
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 2	-0.8 Milliseconds	Standard Deviation 5.64
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: baseline	162.5 Milliseconds	Standard Deviation 22.04
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 6	0.3 Milliseconds	Standard Deviation 17.19
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 2	0.3 Milliseconds	Standard Deviation 10.13
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: baseline	401.0 Milliseconds	Standard Deviation 25.23
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 6	2.9 Milliseconds	Standard Deviation 13.63
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 2	3.5 Milliseconds	Standard Deviation 21.06
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: baseline	408.5 Milliseconds	Standard Deviation 18.42
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 6	-0.9 Milliseconds	Standard Deviation 4.04
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 2	2.6 Milliseconds	Standard Deviation 16.2
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: baseline	93.0 Milliseconds	Standard Deviation 11.13
PF-06700841 1.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 6	-4.1 Milliseconds	Standard Deviation 23.42
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 2	-0.6 Milliseconds	Standard Deviation 12.75
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: baseline	160.7 Milliseconds	Standard Deviation 24.2
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 2	1.1 Milliseconds	Standard Deviation 14.42
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 6	3.5 Milliseconds	Standard Deviation 21.88
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: baseline	93.1 Milliseconds	Standard Deviation 8.69
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 2	0.1 Milliseconds	Standard Deviation 4.79
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 6	-1.3 Milliseconds	Standard Deviation 4
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: baseline	401.0 Milliseconds	Standard Deviation 16.29
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 6	-1.4 Milliseconds	Standard Deviation 14.93
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: baseline	392.0 Milliseconds	Standard Deviation 27.36
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 2	-4.5 Milliseconds	Standard Deviation 15.75
PF-06700841 3.0% Cream QD	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 6	-0.9 Milliseconds	Standard Deviation 20.12
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 6	4.0 Milliseconds	Standard Deviation 14.56
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 6	0.9 Milliseconds	Standard Deviation 6.37
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: baseline	92.2 Milliseconds	Standard Deviation 13
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: baseline	390.9 Milliseconds	Standard Deviation 24.87
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 6	7.8 Milliseconds	Standard Deviation 24.11
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 2	6.0 Milliseconds	Standard Deviation 14.79
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 2	1.4 Milliseconds	Standard Deviation 15.56
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 2	1.5 Milliseconds	Standard Deviation 9.29
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: baseline	156.4 Milliseconds	Standard Deviation 22.65
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 6	4.6 Milliseconds	Standard Deviation 14.27
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: baseline	403.0 Milliseconds	Standard Deviation 16.65
Vehicle Cream Twice Daily (BID)	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 2	1.2 Milliseconds	Standard Deviation 24.03
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 6	0.6 Milliseconds	Standard Deviation 5.49
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 2	2.4 Milliseconds	Standard Deviation 10.32
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 2	0.2 Milliseconds	Standard Deviation 8.07
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 6	2.0 Milliseconds	Standard Deviation 11.94
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: baseline	92.4 Milliseconds	Standard Deviation 13.3
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: baseline	383.8 Milliseconds	Standard Deviation 30.79
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 6	6.5 Milliseconds	Standard Deviation 19.15
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 2	1.2 Milliseconds	Standard Deviation 16.06
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 6	-1.4 Milliseconds	Standard Deviation 20.47
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 2	-2.3 Milliseconds	Standard Deviation 18.69
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: baseline	157.9 Milliseconds	Standard Deviation 23.55
PF-06700841 0.3% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: baseline	397.7 Milliseconds	Standard Deviation 17.05
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: baseline	405.0 Milliseconds	Standard Deviation 20.38
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 6	-0.2 Milliseconds	Standard Deviation 9.67
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 6	0.7 Milliseconds	Standard Deviation 5.67
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 2	-4.6 Milliseconds	Standard Deviation 25.76
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: baseline	157.8 Milliseconds	Standard Deviation 23.15
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 6	5.7 Milliseconds	Standard Deviation 16.11
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QTCF interval: change at week 2	-4.6 Milliseconds	Standard Deviation 15.43
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: baseline	390.6 Milliseconds	Standard Deviation 32.43
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QT interval: change at week 6	4.0 Milliseconds	Standard Deviation 27.74
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: baseline	91.5 Milliseconds	Standard Deviation 11.68
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	PR interval: change at week 2	2.1 Milliseconds	Standard Deviation 7.98
PF-06700841 1.0% Cream BID	Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6	QRS interval: change at week 2	1.0 Milliseconds	Standard Deviation 5.63

Secondary

Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6

Mean change in total cholesterol/HDL cholesterol ratio was assessed and reported.

Time frame: Baseline, Week 6

Arm	Measure	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6	0.0 Ratio	Standard Deviation 0.31
PF-06700841 0.1% Cream QD	Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6	-0.1 Ratio	Standard Deviation 0.48
PF-06700841 0.3% Cream QD	Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6	-0.2 Ratio	Standard Deviation 0.4
PF-06700841 1.0% Cream QD	Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6	-0.0 Ratio	Standard Deviation 0.32
PF-06700841 3.0% Cream QD	Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6	-0.3 Ratio	Standard Deviation 0.77
Vehicle Cream Twice Daily (BID)	Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6	-0.0 Ratio	Standard Deviation 0.35
PF-06700841 0.3% Cream BID	Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6	0.0 Ratio	Standard Deviation 0.46
PF-06700841 1.0% Cream BID	Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6	-0.0 Ratio	Standard Deviation 0.42

Secondary

Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6

Blood pressure included supine and sitting systolic and diastolic BP.

Time frame: Baseline, Weeks 2 and 6

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: Baseline	117.7 Millimeters of mercury	Standard Deviation 13.05
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 6	0.8 Millimeters of mercury	Standard Deviation 9.9
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 2	-1.6 Millimeters of mercury	Standard Deviation 8.49
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 6	-0.2 Millimeters of mercury	Standard Deviation 12.98
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: Baseline	123.3 Millimeters of mercury	Standard Deviation 12.01
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 6	0.6 Millimeters of mercury	Standard Deviation 12.24
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: Baseline	77.7 Millimeters of mercury	Standard Deviation 9.28
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 2	0.5 Millimeters of mercury	Standard Deviation 7.51
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 2	0.3 Millimeters of mercury	Standard Deviation 11.55
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 6	-2.5 Millimeters of mercury	Standard Deviation 7.69
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 2	1.3 Millimeters of mercury	Standard Deviation 12.12
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: Baseline	76.5 Millimeters of mercury	Standard Deviation 9.28
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 2	0.6 Millimeters of mercury	Standard Deviation 6.47
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: Baseline	75.2 Millimeters of mercury	Standard Deviation 8.79
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 6	0.0 Millimeters of mercury	Standard Deviation 5.79
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 2	-1.4 Millimeters of mercury	Standard Deviation 9.61
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 6	1.1 Millimeters of mercury	Standard Deviation 10.06
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 2	0.7 Millimeters of mercury	Standard Deviation 7.93
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: Baseline	120.8 Millimeters of mercury	Standard Deviation 10.26
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: Baseline	123.2 Millimeters of mercury	Standard Deviation 12.35
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: Baseline	80.1 Millimeters of mercury	Standard Deviation 6.76
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 2	-1.9 Millimeters of mercury	Standard Deviation 11.86
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 6	1.5 Millimeters of mercury	Standard Deviation 7.61
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 6	-7.5 Millimeters of mercury	Standard Deviation 8.67
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 6	-1.6 Millimeters of mercury	Standard Deviation 11.97
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 6	-9.4 Millimeters of mercury	Standard Deviation 8.95
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 6	-0.7 Millimeters of mercury	Standard Deviation 8.32
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: Baseline	78.8 Millimeters of mercury	Standard Deviation 8.39
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 2	0.0 Millimeters of mercury	Standard Deviation 9.44
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 2	-0.4 Millimeters of mercury	Standard Deviation 8.5
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 6	2.0 Millimeters of mercury	Standard Deviation 14.05
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 2	0.5 Millimeters of mercury	Standard Deviation 14.73
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: Baseline	120.2 Millimeters of mercury	Standard Deviation 12.43
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 2	-3.9 Millimeters of mercury	Standard Deviation 14.54
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: Baseline	77.8 Millimeters of mercury	Standard Deviation 10.02
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: Baseline	123.0 Millimeters of mercury	Standard Deviation 13.89
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: Baseline	69.6 Millimeters of mercury	Standard Deviation 11.48
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: Baseline	116.9 Millimeters of mercury	Standard Deviation 17.76
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 6	1.0 Millimeters of mercury	Standard Deviation 14.63
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 2	2.3 Millimeters of mercury	Standard Deviation 6.99
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: Baseline	74.5 Millimeters of mercury	Standard Deviation 8.26
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 2	1.3 Millimeters of mercury	Standard Deviation 13.59
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 6	1.1 Millimeters of mercury	Standard Deviation 15.61
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 6	0.5 Millimeters of mercury	Standard Deviation 7.96
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 6	0.2 Millimeters of mercury	Standard Deviation 9.13
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: Baseline	119.7 Millimeters of mercury	Standard Deviation 9.08
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 2	1.6 Millimeters of mercury	Standard Deviation 10.33
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 2	1.6 Millimeters of mercury	Standard Deviation 12
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 2	1.2 Millimeters of mercury	Standard Deviation 8.32
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: Baseline	122.6 Millimeters of mercury	Standard Deviation 12.76
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 2	-0.3 Millimeters of mercury	Standard Deviation 10.25
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 6	-3.4 Millimeters of mercury	Standard Deviation 11.02
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: Baseline	124.6 Millimeters of mercury	Standard Deviation 11.25
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 2	-2.4 Millimeters of mercury	Standard Deviation 11.76
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 6	-8.4 Millimeters of mercury	Standard Deviation 10.81
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: Baseline	75.9 Millimeters of mercury	Standard Deviation 8.78
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 6	-0.9 Millimeters of mercury	Standard Deviation 10.65
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: Baseline	80.9 Millimeters of mercury	Standard Deviation 8.21
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 2	-2.9 Millimeters of mercury	Standard Deviation 10.77
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 6	-5.3 Millimeters of mercury	Standard Deviation 9.27
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 6	-1.4 Millimeters of mercury	Standard Deviation 10.49
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 6	-0.6 Millimeters of mercury	Standard Deviation 14.4
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: Baseline	119.4 Millimeters of mercury	Standard Deviation 12.96
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: Baseline	75.1 Millimeters of mercury	Standard Deviation 5.77
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 6	-2.8 Millimeters of mercury	Standard Deviation 12.6
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: Baseline	123.1 Millimeters of mercury	Standard Deviation 12.4
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 2	-2.8 Millimeters of mercury	Standard Deviation 6.69
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 2	-3.1 Millimeters of mercury	Standard Deviation 10.46
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 2	-0.3 Millimeters of mercury	Standard Deviation 8.02
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 6	-1.6 Millimeters of mercury	Standard Deviation 6.22
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: Baseline	77.5 Millimeters of mercury	Standard Deviation 8.71
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 2	1.7 Millimeters of mercury	Standard Deviation 8.2
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 6	-3.6 Millimeters of mercury	Standard Deviation 8.37
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 2	1.6 Millimeters of mercury	Standard Deviation 8.89
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 2	1.1 Millimeters of mercury	Standard Deviation 9.81
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 6	1.9 Millimeters of mercury	Standard Deviation 9.72
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: Baseline	122.9 Millimeters of mercury	Standard Deviation 15.25
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: Baseline	77.1 Millimeters of mercury	Standard Deviation 12
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 6	2.1 Millimeters of mercury	Standard Deviation 12.41
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 2	3.5 Millimeters of mercury	Standard Deviation 13.65
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 6	-0.3 Millimeters of mercury	Standard Deviation 7.89
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 2	4.5 Millimeters of mercury	Standard Deviation 5.8
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: Baseline	117.1 Millimeters of mercury	Standard Deviation 14.07
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: Baseline	74.4 Millimeters of mercury	Standard Deviation 8.2
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: Baseline	73.7 Millimeters of mercury	Standard Deviation 8.59
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 6	0.5 Millimeters of mercury	Standard Deviation 6.32
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 6	-1.5 Millimeters of mercury	Standard Deviation 5.8
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 2	-1.2 Millimeters of mercury	Standard Deviation 6.49
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: change at week 6	0.4 Millimeters of mercury	Standard Deviation 8.41
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 6	0.6 Millimeters of mercury	Standard Deviation 10.31
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: Baseline	118.9 Millimeters of mercury	Standard Deviation 12.43
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting diastolic BP: Baseline	80.3 Millimeters of mercury	Standard Deviation 7.83
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine diastolic BP: change at week 2	1.4 Millimeters of mercury	Standard Deviation 7.74
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: Baseline	125.6 Millimeters of mercury	Standard Deviation 12.21
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Supine systolic BP: change at week 2	2.9 Millimeters of mercury	Standard Deviation 8.48
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6	Sitting systolic BP: change at week 2	4.4 Millimeters of mercury	Standard Deviation 11.68

Secondary

Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6

Time frame: Baseline, Weeks 2 and 6

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Baseline	69.6 Beats per minute	Standard Deviation 12.58
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 6	2.1 Beats per minute	Standard Deviation 10.59
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 2	0.5 Beats per minute	Standard Deviation 10.41
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 6	0.3 Beats per minute	Standard Deviation 8.04
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 2	0.2 Beats per minute	Standard Deviation 8.11
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Baseline	69.5 Beats per minute	Standard Deviation 9.82
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 6	-1.4 Beats per minute	Standard Deviation 11.9
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Baseline	72.9 Beats per minute	Standard Deviation 14.3
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 2	-2.5 Beats per minute	Standard Deviation 9.66
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Baseline	67.9 Beats per minute	Standard Deviation 9.31
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 2	1.1 Beats per minute	Standard Deviation 9.13
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 6	0.9 Beats per minute	Standard Deviation 9.71
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 2	0.5 Beats per minute	Standard Deviation 6.54
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Baseline	68.8 Beats per minute	Standard Deviation 11.76
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 6	1.8 Beats per minute	Standard Deviation 8.73
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 2	3.7 Beats per minute	Standard Deviation 9.47
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Baseline	69.4 Beats per minute	Standard Deviation 11.15
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 6	4.1 Beats per minute	Standard Deviation 6.76
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 2	2.8 Beats per minute	Standard Deviation 8.28
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Baseline	70.1 Beats per minute	Standard Deviation 11.18
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 6	0.5 Beats per minute	Standard Deviation 9.12
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Baseline	68.2 Beats per minute	Standard Deviation 9.59
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 2	4.1 Beats per minute	Standard Deviation 9.16
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6	Change at week 6	1.8 Beats per minute	Standard Deviation 8.64

Secondary

Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6

Time frame: Baseline, Weeks 2 and 6

Arm	Measure	Group	Value (MEAN)	Dispersion
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 2	-0.1 Degree Celsius	Standard Deviation 0.41
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 6	-0.0 Degree Celsius	Standard Deviation 0.4
Vehicle Cream Once Daily (QD)	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Baseline	36.5 Degree Celsius	Standard Deviation 0.33
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 6	-0.0 Degree Celsius	Standard Deviation 0.29
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Baseline	36.5 Degree Celsius	Standard Deviation 0.43
PF-06700841 0.1% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 2	-0.1 Degree Celsius	Standard Deviation 0.3
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Baseline	36.6 Degree Celsius	Standard Deviation 0.44
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 6	0.0 Degree Celsius	Standard Deviation 0.38
PF-06700841 0.3% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 2	0.0 Degree Celsius	Standard Deviation 0.38
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 2	-0.0 Degree Celsius	Standard Deviation 0.43
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Baseline	36.6 Degree Celsius	Standard Deviation 0.33
PF-06700841 1.0% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 6	0.1 Degree Celsius	Standard Deviation 0.32
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 2	0.1 Degree Celsius	Standard Deviation 0.35
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Baseline	36.5 Degree Celsius	Standard Deviation 0.37
PF-06700841 3.0% Cream QD	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 6	0.0 Degree Celsius	Standard Deviation 0.29
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 2	-0.0 Degree Celsius	Standard Deviation 0.38
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Baseline	36.5 Degree Celsius	Standard Deviation 0.29
Vehicle Cream Twice Daily (BID)	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 6	0.1 Degree Celsius	Standard Deviation 0.5
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 2	0.0 Degree Celsius	Standard Deviation 0.34
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Baseline	36.6 Degree Celsius	Standard Deviation 0.41
PF-06700841 0.3% Cream BID	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 6	0.0 Degree Celsius	Standard Deviation 0.37
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Baseline	36.6 Degree Celsius	Standard Deviation 0.29
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 2	0.0 Degree Celsius	Standard Deviation 0.41
PF-06700841 1.0% Cream BID	Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6	Change at week 6	-0.0 Degree Celsius	Standard Deviation 0.46

Secondary

Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings

Clinically significant ECG criteria included PR interval: value greater than (\>) 280 millisecond (msec), percentage change greater than equal to (\>=) 25/50 percentage, QRS interval: value \>120 msec, percentage change \>= 50% and QT interval corrected using the Fridericia's formula (QTCF) value 450 msec and 30\<=change\<60.

Time frame: Baseline up to Week 6

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
Vehicle Cream Once Daily (QD)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 30<=Change<60	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : value >280 msec	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : %change>=25/50%	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: value >120 msec	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 450 msec	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: %Change>=50%	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: value >120 msec	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : value >280 msec	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: %Change>=50%	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 30<=Change<60	1 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : %change>=25/50%	1 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 450 msec	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 450 msec	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: value >120 msec	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : %change>=25/50%	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: %Change>=50%	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 30<=Change<60	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : value >280 msec	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 450 msec	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : value >280 msec	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : %change>=25/50%	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: value >120 msec	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: %Change>=50%	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 30<=Change<60	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 450 msec	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : %change>=25/50%	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 30<=Change<60	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : value >280 msec	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: %Change>=50%	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: value >120 msec	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: value >120 msec	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: %Change>=50%	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : %change>=25/50%	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 450 msec	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : value >280 msec	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 30<=Change<60	2 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: %Change>=50%	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 450 msec	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : value >280 msec	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: value >120 msec	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 30<=Change<60	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : %change>=25/50%	2 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: %Change>=50%	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QRS interval: value >120 msec	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 30<=Change<60	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	QTCF: 450 msec	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : value >280 msec	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings	PR interval : %change>=25/50%	0 Participants

Secondary

Number of Participants With Each Severity Grade in Local Tolerability Assessments

Local tolerability skin assessments were performed by the investigator and graded based on severity from grade 0 to 4 as: grade 0=none (no evidence of local intolerance); grade 1=mild (minimal erythema and/or oedema, slight glazed appearance); grade 2= moderate (definite erythema and/or oedema with peeling and/or cracking but needs no adaptation of posology) grade 3=severe (erythema, oedema glazing with fissures, few vesicles or papules consider removing topical agent \[if still in place\]) and grade 4= very severe (strong reaction spreading beyond the treated area, bullous reaction, erosions: removal of topical agent \[if still in place\]). Higher grades indicated worsening of condition. Only those categories in which at least 1 participant had data were reported.

Time frame: Day 1 and any day on of Week 1, 2, 4, 6: pre dose (before application of IP) and post dose (after application of IP); Follow up visit (28 days after last dose of study drug = maximum up to Day 71) and Early termination (anytime within week 11)

Population: Safety analysis set included all participants who were randomly assigned to study drug and who applied at least 1 dose of study drug.

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: none	26 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: none	31 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: severe	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: none	22 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: moderate	2 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: moderate	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: none	33 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: mild	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: moderate	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: moderate	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: mild	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: mild	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: none	28 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: none	28 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: mild	2 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: none	24 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: none	29 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: mild	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: moderate	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: none	6 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: mild	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: moderate	2 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: severe	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: moderate	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: moderate	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: moderate	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: moderate	2 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: mild	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: mild	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: mild	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: moderate	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: mild	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: none	35 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: mild	3 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: moderate	2 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: none	27 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: none	25 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: mild	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: mild	2 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: moderate	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: none	26 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: severe	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: none	28 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: none	25 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: mild	2 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: moderate	2 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: mild	2 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: none	26 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: none	26 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: mild	2 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: moderate	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: moderate	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: mild	2 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: none	36 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: none	35 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: moderate	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: moderate	1 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: moderate	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: moderate	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: mild	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: severe	1 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: mild	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: moderate	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: mild	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: moderate	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: moderate	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: none	29 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: mild	3 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: mild	1 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: moderate	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: none	5 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: mild	2 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: none	26 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: none	24 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: mild	1 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: none	28 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: moderate	3 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: none	29 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: moderate	2 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: none	26 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: moderate	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: moderate	3 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: mild	2 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: mild	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: moderate	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: none	3 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: none	30 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: moderate	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: mild	2 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: moderate	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: mild	3 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: none	29 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: moderate	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: none	28 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: none	31 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: severe	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: mild	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: moderate	4 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: none	30 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: moderate	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: none	30 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: mild	2 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: mild	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: none	25 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: moderate	3 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: none	28 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: severe	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: mild	3 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: moderate	2 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: mild	2 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: none	29 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: mild	2 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: mild	2 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: mild	2 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: mild	3 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: severe	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: mild	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: none	30 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: none	33 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: mild	3 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: none	29 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: moderate	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: none	30 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: moderate	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: none	30 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: mild	3 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: mild	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: moderate	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: moderate	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: mild	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: mild	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: moderate	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: none	31 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: moderate	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: none	30 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: mild	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: mild	2 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: none	2 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: moderate	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: moderate	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: moderate	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: mild	2 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: none	25 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: none	30 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: mild	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: none	30 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: mild	2 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: moderate	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: none	33 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: moderate	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: moderate	4 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: severe	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: none	29 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: moderate	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: none	30 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: mild	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: moderate	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: none	29 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: mild	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: moderate	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: none	30 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: none	36 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: mild	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: moderate	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: none	35 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: mild	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: moderate	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: none	30 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: mild	3 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: moderate	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: none	28 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: mild	2 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: moderate	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: none	30 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: mild	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: moderate	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: mild	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: mild	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: severe	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: none	28 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: mild	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: moderate	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: severe	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: moderate	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: none	29 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: mild	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: moderate	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: none	2 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: mild	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: moderate	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: moderate	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: moderate	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: none	34 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: moderate	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: mild	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: mild	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: none	22 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: none	21 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: mild	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: moderate	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: none	35 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: moderate	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: moderate	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: none	9 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: moderate	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: moderate	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: mild	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: severe	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: none	23 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: none	24 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: mild	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: none	24 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: none	27 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: none	30 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: moderate	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: mild	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: severe	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: mild	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: moderate	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: mild	2 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: moderate	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: mild	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: moderate	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: none	23 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: none	25 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: mild	3 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: mild	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: mild	2 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: none	30 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: none	32 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: none	32 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: mild	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: moderate	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: mild	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: mild	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: none	33 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: severe	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: moderate	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: mild	4 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: mild	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: none	26 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: none	32 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: mild	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: moderate	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: none	31 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: moderate	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: mild	2 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: none	34 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: severe	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: moderate	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: none	30 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: moderate	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: moderate	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: mild	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: mild	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: none	31 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: moderate	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: moderate	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: moderate	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: none	2 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: mild	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: mild	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: none	31 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: moderate	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: moderate	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: mild	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: mild	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: none	33 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: none	28 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: mild	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: mild	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: none	33 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: mild	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: none	30 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: mild	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: severe	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability after: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: none	33 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability before: mild	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: none	31 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: mild	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 1: tolerability after: none	31 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: none	36 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: none	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: severe	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability before: mild	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: mild	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability before: none	32 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: none	30 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Day 1: tolerability before: moderate	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Follow Up: tolerability: mild	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability after: mild	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 6: tolerability after: none	30 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 4: tolerability after: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Week 2: tolerability before: moderate	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Each Severity Grade in Local Tolerability Assessments	Early termination:tolerability: mild	1 Participants

Secondary

Number of Participants With Laboratory Abnormalities

Hemoglobin (HGB),hematocrit,erythrocytes (ery.),HDL cholesterol (chl.)\<0.8\*lower limit of normal(LLN);reticulocytes (ret.), ret./ery. (%)\<0.5\*LLN,\>1.5\*upper limit of normal (ULN);ery. mean corpuscular (EMC) volume,EMC HGB,EMC HGB concentration,potassium,chloride,calcium,bicarbonate\<0.9\*LLN,\>1.1\*ULN;platelets\<0.5\*LLN,\>1.75\*ULN;leukocytes (leu.),glucose\<0.6\*LLN,\>1.5\*ULN;lymphocytes (lym.), lym./leu.(%), neutrophils (neu.), neu./leu. (%), protein,albumin \<0.8\*LLN,\>1.2\*ULN;basophils (bas.), bas./leu.(%), eosinophils (eos.), eos./leu., monocytes (mon.), mon./leu.(%), urate \>1.2\*ULN;bilirubin (total, direct, indirect)\>1.5\*ULN;aspartate/alanine aminotransferase, gamma glutamyl transferase, lactate dehydrogenase, alkaline phosphatase\>3.0\*ULN;urea nitrogen, creatinine, triglycerides, chl.\>1.3\*ULN; sodium \<0.95\*LLN,\>1.05\*ULN; creatine kinase \>2.0\*ULN;Urine: pH\<4.5,\>8;glucose, ketones, protein, HGB, urobilinogen,bilirubin,nitrite,leukocyte esterase\>=1;ery., leu.\>= 20;hyaline casts\>1;bacteria\>20.

Time frame: Baseline (Day 1) up to at least 28 days after last dose of study drug (approximately up to Week 11)

Arm	Measure	Value (COUNT_OF_PARTICIPANTS)
Vehicle Cream Once Daily (QD)	Number of Participants With Laboratory Abnormalities	26 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Laboratory Abnormalities	22 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Laboratory Abnormalities	23 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Laboratory Abnormalities	22 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Laboratory Abnormalities	16 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Laboratory Abnormalities	21 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Laboratory Abnormalities	24 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Laboratory Abnormalities	24 Participants

Secondary

Number of Participants With Pre-defined Criteria For Vital Signs

Pre-defined criteria included: 1) Diastolic blood pressure (DBP), a) sitting DBP: change of \>= 20 millimeter of mercury (mmHg) increase, b) sitting DBP: change of \>=20mmHg decrease, c) supine DBP: less than (\<) 50 mmHg, d) supine DBP: change of \>= 20mmHg increase, e) supine DBP: change of \>= 20mmHg decrease; 2) Systolic blood pressure (SBP), a) sitting SBP: \<90 mmHg, b) sitting SBP: change of \>=30mmHg increase, c) sitting SBP: change of \>=30mmHg decrease, d) supine SBP: change of \>=30mmHg increase, e) supine SBP: change of \>=30mmHg decrease and f) Supine SBP: value \<90mmHg.

Time frame: Baseline up to Week 6

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: <90mmHg	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg decrease	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Value <90mmHg	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20 mm Hg increase	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg increase	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Value <50 mmHg	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20mmHg decrease	1 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg increase	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg increase	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg decrease	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg decrease	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg increase	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg increase	1 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg decrease	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg increase	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20 mm Hg increase	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Value <90mmHg	1 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20mmHg decrease	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: <90mmHg	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Value <50 mmHg	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg decrease	0 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg decrease	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20mmHg decrease	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg increase	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Value <90mmHg	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20 mm Hg increase	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Value <50 mmHg	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg decrease	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg increase	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg increase	1 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg decrease	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg decrease	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: <90mmHg	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Value <50 mmHg	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg increase	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg decrease	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Value <90mmHg	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg decrease	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg decrease	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: <90mmHg	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg increase	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20mmHg decrease	1 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg increase	2 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20 mm Hg increase	2 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg decrease	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20 mm Hg increase	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20mmHg decrease	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Value <50 mmHg	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg increase	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg decrease	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: <90mmHg	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg increase	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg decrease	1 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg increase	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Value <90mmHg	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20 mm Hg increase	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg increase	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg decrease	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg increase	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: <90mmHg	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg increase	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Value <90mmHg	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20mmHg decrease	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Value <50 mmHg	1 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg decrease	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg decrease	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20mmHg decrease	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg decrease	2 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg decrease	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20 mm Hg increase	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: <90mmHg	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg increase	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg increase	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Value <90mmHg	0 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg increase	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg decrease	1 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Value <50 mmHg	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg increase	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg decrease	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg decrease	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Change >= 20mmHg increase	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: change >= 30mmHg increase	1 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine DBP: Value <50 mmHg	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20mmHg decrease	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Change >= 30mmHg decrease	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting DBP: Change >= 20 mm Hg increase	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Sitting SBP: <90mmHg	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Pre-defined Criteria For Vital Signs	Supine SBP: Value <90mmHg	0 Participants

Secondary

Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)

An AE was any untoward medical occurrence in a participant who received investigational product without regard to possibility of causal relationship. SAE was an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly; medically important events. Treatment-emergent were events between first dose of investigational product and up to 28 days after the last dose of investigational product that were absent before treatment or that worsened relative to pretreatment state. AEs included both SAEs and all non-SAEs.

Time frame: Baseline (Day 1) up to at least 28 days after last dose of study drug (approximately up to Week 11)

Population: Safety analysis set included all participants who were randomly assigned to study drug and who applied at least 1 dose of study drug.

Arm	Measure	Group	Value (COUNT_OF_PARTICIPANTS)
Vehicle Cream Once Daily (QD)	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	SAEs	0 Participants
Vehicle Cream Once Daily (QD)	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	TEAEs	18 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	TEAEs	17 Participants
PF-06700841 0.1% Cream QD	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	SAEs	0 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	TEAEs	11 Participants
PF-06700841 0.3% Cream QD	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	SAEs	0 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	TEAEs	12 Participants
PF-06700841 1.0% Cream QD	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	SAEs	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	SAEs	0 Participants
PF-06700841 3.0% Cream QD	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	TEAEs	10 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	SAEs	0 Participants
Vehicle Cream Twice Daily (BID)	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	TEAEs	17 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	TEAEs	9 Participants
PF-06700841 0.3% Cream BID	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	SAEs	0 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	TEAEs	14 Participants
PF-06700841 1.0% Cream BID	Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)	SAEs	0 Participants

Secondary

Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation

The severity of itch (pruritus) due to AD was assessed using a horizontal NRS. Participants at specified time points were asked the following question: How would you rate your itch due to AD at the worst moment during the previous 24 hours? The scale ranged from 0-10, where 0= no itch and 10= worst itch imaginable. Higher scores indicated worse itch.

Time frame: Baseline, Weeks 1, 2, 3, 4 and 6

Population: Full analysis set included all participants who were randomly assigned to study drug and who applied at least 1 dose of study drug. Here, Overall Number of Participants Analyzed signifies participants evaluable for this outcome measure. NRI method: participants with missing values were considered to be non-responders.

Arm	Measure	Group	Value (NUMBER)
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	16.2 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	40.5 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	35.1 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	21.6 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	24.3 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	30.6 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	38.9 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	41.7 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	38.9 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	16.7 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	42.9 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	51.4 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	20.0 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	51.4 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	48.6 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	59.5 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	56.8 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	29.7 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	48.6 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	62.2 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	58.3 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	44.4 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	61.1 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	58.3 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	61.1 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	33.3 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	30.6 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	25.0 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	13.9 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	30.6 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	51.4 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	28.6 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	45.7 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	60.0 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	60.0 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	60.0 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	60.0 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	25.7 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	57.1 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	37.1 Percentage of participants

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.524690% CI: [-14.7, 16.4]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.390690% CI: [-12.5, 19.9]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.119390% CI: [-3.2, 30.6]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.004890% CI: [8.8, 45.5]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.077790% CI: [-2, 31.1]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.124590% CI: [-4.3, 28]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.332290% CI: [-12.2, 24.4]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.053590% CI: [-0.3, 36.5]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.015990% CI: [4.5, 41.9]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.000890% CI: [15.4, 54]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.038690% CI: [1.5, 38.8]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.148590% CI: [-6.4, 30.3]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.06290% CI: [-0.8, 34.8]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.008990% CI: [6.5, 44.4]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.000590% CI: [17.5, 54.7]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.000790% CI: [15.4, 54]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.071190% CI: [-2, 37.5]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.026690% CI: [2.7, 42.5]Chan and Zhang Exact Method

Comparison: At week 4: Risk difference = difference in percentage of participants.p-value: 0.417390% CI: [-15.3, 23.1]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.109690% CI: [-4.3, 35.6]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.013390% CI: [6.1, 45.7]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.030490% CI: [2.6, 41.7]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.007890% CI: [7.2, 47.6]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.496690% CI: [-18.4, 20.4]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.275390% CI: [-9.3, 30.1]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.103690% CI: [-4.2, 35.7]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.045790% CI: [0.4, 39.6]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.007890% CI: [7.2, 47.6]Chan and Zhang Exact Method

Secondary

Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation

Time frame: Baseline, Weeks 1, 2, 3, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)

Arm	Measure	Group	Value (NUMBER)
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 1	0.0 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 4	18.2 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 6	18.2 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Follow-up visit	9.1 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 3	12.1 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 2	9.1 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 6	30.0 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 2	10.0 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 3	23.3 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Follow-up visit	30.0 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 4	26.7 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 1	3.3 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 6	34.4 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 1	3.1 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 3	15.6 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 4	28.1 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 2	9.4 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Follow-up visit	21.9 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 3	32.3 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 6	45.2 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 4	35.5 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Follow-up visit	19.4 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 1	16.1 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 2	19.4 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 3	32.1 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Follow-up visit	21.4 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 4	50.0 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 6	50.0 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 2	25.0 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 1	10.7 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 2	10.0 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 6	16.7 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Follow-up visit	20.0 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 1	3.3 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 3	10.0 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 4	10.0 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 3	20.0 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Follow-up visit	20.0 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 4	30.0 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 6	33.3 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 1	3.3 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 2	13.3 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Follow-up visit	7.4 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 1	11.1 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 3	37.0 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 4	37.0 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 6	40.7 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation	At Week 2	33.3 Percentage of participants

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.24590% CI: [-5.4, 14.9]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.257590% CI: [-5.3, 14]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.008790% CI: [5.7, 31]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.039290% CI: [0.8, 25.4]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 190% CI: [-11.2, 11.2]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.152890% CI: [-4.9, 22.5]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.498990% CI: [-12.7, 15.2]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.541990% CI: [-13.6, 14.2]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.136290% CI: [-5, 26.2]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.054190% CI: [-0.4, 33.9]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.394590% CI: [-12, 19.5]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.020190% CI: [3.9, 41.8]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.137290% CI: [-5.4, 28.2]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.392490% CI: [-11.6, 19.1]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.031190% CI: [2.4, 38.3]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.039290% CI: [0.8, 38.1]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.154190% CI: [-6.2, 26.4]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.009190% CI: [6.8, 45.4]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.283590% CI: [-9.5, 27]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.2790% CI: [-8.7, 27.8]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.066290% CI: [-1.4, 36.2]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.00590% CI: [9.2, 50.4]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.030290% CI: [2.2, 38.3]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.009190% CI: [6.8, 45.4]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.156190% CI: [-6.5, 30.2]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.075390% CI: [-2.7, 34.8]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.010890% CI: [5.7, 46]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.00590% CI: [9.2, 50.4]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.077590% CI: [-2.9, 35.7]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.024390% CI: [3.4, 43.4]Chan and Zhang Exact Method

Comparison: At follow-up visit: Risk difference = difference in percentage of participants.p-value: 0.023490% CI: [3.5, 38.8]Chan and Zhang Exact Method

Comparison: At follow-up visit: Risk difference = difference in percentage of participants.p-value: 0.113490% CI: [-2.8, 29.3]Chan and Zhang Exact Method

Comparison: At follow-up visit: Risk difference = difference in percentage of participants.p-value: 0.136290% CI: [-5, 26.2]Chan and Zhang Exact Method

Comparison: At follow-up visit: Risk difference = difference in percentage of participants.p-value: 0.102990% CI: [-3.4, 29.8]Chan and Zhang Exact Method

Comparison: At follow-up visit: Risk difference = difference in percentage of participants.p-value: 190% CI: [-17.9, 17.9]Chan and Zhang Exact Method

Comparison: At follow-up visit: Risk difference = difference in percentage of participants.p-value: 0.897290% CI: [-28.8, 3.5]Chan and Zhang Exact Method

Secondary

Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation

Time frame: Baseline, Weeks 1, 2, 3, 4 and 6

Population: Full analysis set included all participants who were randomly assigned to study drug and who applied at least 1 dose of study drug. NRI method: participants with missing values were considered to be non-responders.

Arm	Measure	Group	Value (NUMBER)
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	5.4 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	35.1 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	24.3 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	5.4 Percentage of participants
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	8.1 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	10.8 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	21.6 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	32.4 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	16.2 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	0.0 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	27.8 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	52.8 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	19.4 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	38.9 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	36.1 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	43.2 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	54.1 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	5.4 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	24.3 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	43.2 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	41.7 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	16.7 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	38.9 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	50.0 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	50.0 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	19.4 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	22.2 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	13.9 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	0.0 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	16.7 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	19.4 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	13.9 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	25.0 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	36.1 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	36.1 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 6	51.4 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 4	48.6 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 1	21.6 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 3	43.2 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation	At Week 2	32.4 Percentage of participants

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.070890% CI: [-1.4, 25]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.896490% CI: [-16.1, 2]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.039190% CI: [1, 28.2]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 190% CI: [-10.8, 10.8]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.012290% CI: [4.7, 27]Chan and Zhang Exact Method

Comparison: At Week 1: Risk difference = difference in percentage of participants.p-value: 0.001690% CI: [11, 35.6]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.39590% CI: [-9.8, 16.1]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.017390% CI: [4.2, 35.6]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.032790% CI: [1.4, 31]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.001190% CI: [13.2, 46.6]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.134890% CI: [-5, 27.2]Chan and Zhang Exact Method

Comparison: At Week 2: Risk difference = difference in percentage of participants.p-value: 0.032890% CI: [1.5, 34.8]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.076990% CI: [-1.8, 24.4]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.000590% CI: [13.2, 46]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: <0.000190% CI: [22.1, 53.1]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.000190% CI: [19.7, 51.8]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 190% CI: [-16.5, 16.5]Chan and Zhang Exact Method

Comparison: At Week 3: Risk difference = difference in percentage of participants.p-value: 0.017390% CI: [4.5, 41.5]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.566390% CI: [-19.9, 14.2]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.124390% CI: [-3.8, 32.6]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.04690% CI: [-0.5, 36.6]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.01390% CI: [4.8, 43.3]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.119490% CI: [-4.2, 31.4]Chan and Zhang Exact Method

Comparison: At Week 4: Risk difference = difference in percentage of participants.p-value: 0.009790% CI: [6.5, 44.4]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.555690% CI: [-21, 16.1]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.076190% CI: [-2.5, 36.5]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.058390% CI: [-0.8, 37.6]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.124590% CI: [-5, 33.7]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.038290% CI: [1.5, 36.5]Chan and Zhang Exact Method

Comparison: At Week 6: Risk difference = difference in percentage of participants.p-value: 0.001190% CI: [13.2, 51.4]Chan and Zhang Exact Method

Secondary

Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation

IGA assesses severity of participant's AD on a 5 point scale. 0= clear, no inflammatory signs of AD; 1= almost clear, AD not fully cleared- light pink residual lesions (except post-inflammatory hyperpigmentation), just perceptible erythema, papulation/induration lichenification, excoriation, and no oozing/crusting; 2= mild AD with light red lesions, slight but definite erythema, papulation/induration, lichenification, excoriation and no oozing/crusting; 3= moderate AD with red lesions, moderate erythema, papulation/induration, lichenification, excoriation and slight oozing/crusting and 4= severe AD with deep dark red lesions, severe erythema, papulation/induration, lichenification, excoriation and moderate to severe oozing/crusting. Higher scores indicating more severity of AD. Assessment excluded soles, palms and scalp.

Time frame: Baseline, Week 6

Population: Full analysis set included all participants who were randomly assigned to study drug and who applied at least 1 dose of study drug. Non-Responder Imputation (NRI) method: participants with missing values were considered to be non-responders.

Arm	Measure	Value (NUMBER)
Vehicle Cream Once Daily (QD)	Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation	10.8 Percentage of participants
PF-06700841 0.1% Cream QD	Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation	29.7 Percentage of participants
PF-06700841 0.3% Cream QD	Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation	33.3 Percentage of participants
PF-06700841 1.0% Cream QD	Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation	40.5 Percentage of participants
PF-06700841 3.0% Cream QD	Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation	44.4 Percentage of participants
Vehicle Cream Twice Daily (BID)	Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation	13.9 Percentage of participants
PF-06700841 0.3% Cream BID	Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation	33.3 Percentage of participants
PF-06700841 1.0% Cream BID	Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation	27.0 Percentage of participants

Comparison: Risk difference = difference in percentage of participants.p-value: 0.024490% CI: [2.4, 34.7]Chan and Zhang Exact Method

Comparison: Risk difference = difference in percentage of participants.p-value: 0.011390% CI: [4.8, 38.6]Chan and Zhang Exact Method

Comparison: Risk difference = difference in percentage of participants.p-value: 0.001890% CI: [11, 45.7]Chan and Zhang Exact Method

Comparison: Risk difference = difference in percentage of participants.p-value: 0.000790% CI: [13.7, 49.9]Chan and Zhang Exact Method

Comparison: Risk difference = difference in percentage of participants.p-value: 0.028990% CI: [1.8, 36.5]Chan and Zhang Exact Method

Comparison: Risk difference = difference in percentage of participants.p-value: 0.114590% CI: [-2.9, 29.6]Chan and Zhang Exact Method

Secondary

Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit

4 body regions were evaluated: head and neck, upper limbs, trunk (including axillae and groin) and lower limbs (including buttocks). Scalp, palms and soles were excluded. BSA was calculated using handprint method. Number of handprints (size of participant's full palmer hand) fitting in the affected area of a body region was estimated. Maximum number of handprints were 10 for head and neck, 20 for upper limbs, 30 for trunk and 40 for lower limbs. Surface area of body region equivalent to 1 handprint: 1 handprint was equal to 10% for head and neck, 5% for upper limbs, 3.33% for trunk and 2.5% for lower limbs. Percent BSA for a body region was calculated as = total number of handprints in a body region \* % surface area equivalent to 1 handprint. Overall % BSA for an individual: arithmetic mean of % BSA of all 4 body regions, ranged from 0 to 100%, with higher values representing greater severity of AD.

Time frame: Baseline, Weeks 1, 2, 3, 4, 6 and follow up visit (28 days after last dose of study drug = maximum up to Day 71)

Population: Full analysis set included all participants who were randomly assigned to study drug and who applied at least 1 dose of study drug. Here, Overall Number of Participants Analyzed signifies participants evaluable for this outcome measure and number analyzed signifies participants evaluable for the each specified time point.

Arm	Measure	Group	Value (LEAST_SQUARES_MEAN)
Vehicle Cream Once Daily (QD)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Follow-up visit	-23.6 Percent change
Vehicle Cream Once Daily (QD)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 1	-2.4 Percent change
Vehicle Cream Once Daily (QD)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 2	-15.3 Percent change
Vehicle Cream Once Daily (QD)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 3	-17.1 Percent change
Vehicle Cream Once Daily (QD)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 6	-21.6 Percent change
Vehicle Cream Once Daily (QD)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 4	-25.9 Percent change
PF-06700841 0.1% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 3	-13.1 Percent change
PF-06700841 0.1% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 1	-2.9 Percent change
PF-06700841 0.1% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 4	-20.1 Percent change
PF-06700841 0.1% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Follow-up visit	-24.5 Percent change
PF-06700841 0.1% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 2	-7.2 Percent change
PF-06700841 0.1% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 6	-39.4 Percent change
PF-06700841 0.3% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 6	-59.4 Percent change
PF-06700841 0.3% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 3	-50.6 Percent change
PF-06700841 0.3% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 2	-38.1 Percent change
PF-06700841 0.3% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 4	-55.8 Percent change
PF-06700841 0.3% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Follow-up visit	-42.7 Percent change
PF-06700841 0.3% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 1	-16.2 Percent change
PF-06700841 1.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 6	-63.6 Percent change
PF-06700841 1.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 1	-19.9 Percent change
PF-06700841 1.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 2	-43.6 Percent change
PF-06700841 1.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 3	-55.9 Percent change
PF-06700841 1.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 4	-57.9 Percent change
PF-06700841 1.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Follow-up visit	-37.0 Percent change
PF-06700841 3.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 6	-60.3 Percent change
PF-06700841 3.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 2	-39.0 Percent change
PF-06700841 3.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Follow-up visit	-55.2 Percent change
PF-06700841 3.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 1	-23.0 Percent change
PF-06700841 3.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 4	-56.7 Percent change
PF-06700841 3.0% Cream QD	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 3	-49.2 Percent change
Vehicle Cream Twice Daily (BID)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 3	-25.2 Percent change
Vehicle Cream Twice Daily (BID)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 4	-34.7 Percent change
Vehicle Cream Twice Daily (BID)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 2	-2.5 Percent change
Vehicle Cream Twice Daily (BID)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 6	-31.2 Percent change
Vehicle Cream Twice Daily (BID)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 1	8.5 Percent change
Vehicle Cream Twice Daily (BID)	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Follow-up visit	-26.3 Percent change
PF-06700841 0.3% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 4	-46.4 Percent change
PF-06700841 0.3% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 6	-48.9 Percent change
PF-06700841 0.3% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 1	-16.5 Percent change
PF-06700841 0.3% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 3	-39.8 Percent change
PF-06700841 0.3% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Follow-up visit	-31.6 Percent change
PF-06700841 0.3% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 2	-34.2 Percent change
PF-06700841 1.0% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 4	-57.7 Percent change
PF-06700841 1.0% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 3	-44.0 Percent change
PF-06700841 1.0% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Follow-up visit	-24.6 Percent change
PF-06700841 1.0% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 6	-65.0 Percent change
PF-06700841 1.0% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 1	-17.0 Percent change
PF-06700841 1.0% Cream BID	Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit	At Week 2	-43.1 Percent change

Comparison: At Week 1: Mixed Model Repeated Measure (MMRM) contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.478190% CI: [-14.2, 13.3]Mixed Model Repeated Measure

Comparison: At Week 1: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.052290% CI: [-27.8, 0.2]Mixed Model Repeated Measure

Comparison: At Week 1: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.018790% CI: [-31.4, -3.7]Mixed Model Repeated Measure

Comparison: At Week 1: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.00890% CI: [-34.5, -6.6]Mixed Model Repeated Measure

Comparison: At Week 1: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.040190% CI: [-48.6, -1.5]Mixed Model Repeated Measure

Comparison: At Week 1: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.037990% CI: [-49.2, -1.9]Mixed Model Repeated Measure

Comparison: At Week 2: MMRM contained fixed factors of treatment, visit(Weeks 1, 2, 3, 4, 6 and follow up), treatment-by-visit interaction and baseline value.p-value: 0.767890% CI: [-10.1, 26.3]Mixed Model Repeated Measure

Comparison: At Week 2: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.019390% CI: [-40.9, -4.7]Mixed Model Repeated Measure

Comparison: At Week 2:MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.005290% CI: [-46.5, -10.2]Mixed Model Repeated Measure

Comparison: At Week 2: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.016490% CI: [-42, -5.5]Mixed Model Repeated Measure

Comparison: At Week 2: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.000890% CI: [-47.8, -15.6]Mixed Model Repeated Measure

Comparison: At Week 2: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: <0.000190% CI: [-57, -24.3]Mixed Model Repeated Measure

Comparison: At Week 3: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.626990% CI: [-16.1, 23.9]Mixed Model Repeated Measure

Comparison: At Week 3: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.002790% CI: [-53.1, -13.8]Mixed Model Repeated Measure

Comparison: At Week 3: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.000790% CI: [-58.5, -19.2]Mixed Model Repeated Measure

Comparison: At Week 3: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.004190% CI: [-51.9, -12.3]Mixed Model Repeated Measure

Comparison: At Week 3: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.105490% CI: [-33.9, 4.6]Mixed Model Repeated Measure

Comparison: At Week 3: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.054290% CI: [-38.1, 0.5]Mixed Model Repeated Measure

Comparison: At Week 4: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.684790% CI: [-14.2, 25.9]Mixed Model Repeated Measure

Comparison: At Week 4: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.006290% CI: [-49.4, -10.3]Mixed Model Repeated Measure

Comparison: At Week 4: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.00490% CI: [-51.6, -12.3]Mixed Model Repeated Measure

Comparison: At Week 4: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.005490% CI: [-50.6, -11]Mixed Model Repeated Measure

Comparison: At Week 4: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.107690% CI: [-27.2, 3.9]Mixed Model Repeated Measure

Comparison: At Week 4: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.008290% CI: [-38.6, -7.3]Mixed Model Repeated Measure

Comparison: At Week 6: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.105190% CI: [-41.2, 5.6]Mixed Model Repeated Measure

Comparison: At Week 6: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.003490% CI: [-60.6, -15]Mixed Model Repeated Measure

Comparison: At Week 6: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.001490% CI: [-64.8, -19]Mixed Model Repeated Measure

Comparison: At Week 6: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.00390% CI: [-61.6, -15.6]Mixed Model Repeated Measure

Comparison: At Week 6: MMRM contained fixed factors of treatment, visit(Weeks 1, 2, 3, 4, 6 and follow up), treatment-by-visit interaction and baseline value.p-value: 0.028990% CI: [-33, -2.4]Mixed Model Repeated Measure

Comparison: At Week 6: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.000290% CI: [-49.2, -18.4]Mixed Model Repeated Measure

Comparison: At follow-up visit: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.473990% CI: [-23.9, 22]Mixed Model Repeated Measure

Comparison: At follow-up visit: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.078990% CI: [-41.3, 3.2]Mixed Model Repeated Measure

Comparison: At follow-up visit: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.161190% CI: [-35.7, 8.9]Mixed Model Repeated Measure

Comparison: At follow-up visit: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.012490% CI: [-54.7, -8.5]Mixed Model Repeated Measure

Comparison: At follow-up visit: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.382890% CI: [-34.7, 24.1]Mixed Model Repeated Measure

Comparison: At follow-up visit: MMRM contained fixed factors of treatment, visit, treatment-by-visit interaction and baseline value.p-value: 0.538390% CI: [-27.9, 31.3]Mixed Model Repeated Measure

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026

Dose Ranging Study to Assess Efficacy, Safety, Tolerability and Pharmacokinetics of PF-06700841 Topical Cream in Participants With Mild or Moderate Atopic Dermatitis

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Percent Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation

Change From Baseline in Clinical Chemistry-Lactate Dehydrogenase Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Change From Baseline in Clinical Chemistry- Protein and Albumin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Change From Baseline in Clinical Chemistry- Sodium, Potassium, Chloride and Bicarbonate Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Change From Baseline in Clinical Chemistry- Urea Nitrogen, Urate, Calcium and Glucose Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Change From Baseline in Eczema Area and Severity Index (EASI) Total Score at Week 6: Multiple Imputation

Change From Baseline in Electrocardiogram (ECG) Parameter- Heart Rate at Weeks 2 and 6

Change From Baseline in Hematology- Erythrocytes and Reticulocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Change From Baseline in Hematology - Hematocrit, Reticulocytes/Erythrocytes, Lymphocytes/Leukocytes, Neutrophils/Leukocytes, Basophils/Leukocytes, Eosinophils/Leukocytes and Monocytes/Leukocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Change From Baseline in Hematology- Hemoglobin Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Change From Baseline in Hematology- Platelets, Leukocytes, Lymphocytes, Neutrophils, Basophils, Eosinophils and Monocytes Laboratory Values at Weeks 1, 2, 4, 6 and Follow-up Visit

Change From Baseline in Lipids Profile Values at Week 6

Change From Baseline in PR, QRS, QTCF and QT Interval at Weeks 2 and 6

Change From Baseline in Ratio of LDL Cholesterol to HDL Cholesterol Lipids Profile at Week 6

Change From Baseline in Vital Signs- Blood Pressure (BP) at Weeks 2 and 6

Change From Baseline in Vital Signs- Pulse Rate at Weeks 2 and 6

Change From Baseline in Vital Signs- Temperature at Weeks 2 and 6

Number of Participants With Clinically Significant Change in Electrocardiogram (ECG) Findings

Number of Participants With Each Severity Grade in Local Tolerability Assessments

Number of Participants With Laboratory Abnormalities

Number of Participants With Pre-defined Criteria For Vital Signs

Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)

Percentage of Participants Achieving >=2 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation

Percentage of Participants Achieving >=4 Points Reduction in Peak Pruritus Numerical Rating Scale (PP-NRS) From Baseline at Weeks 1, 2, 3, 4, 6 and Follow-up Visit: Non-responder Imputation

Percentage of Participants Achieving >=75% Improvement in Eczema Area and Severity Index Total Score (EASI-75) From Baseline at Weeks 1, 2, 3, 4 and 6: Non-responder Imputation

Percentage of Participants Achieving Investigator's Global Assessment (IGA) Score Clear (0) or Almost Clear (1) and a Reduction From Baseline of Greater Than or Equal to ( >=2) Points at Week 6: Non-responder Imputation

Percent Change From Baseline in Affected Body Surface Area (BSA) at Weeks 1, 2, 3, 4, 6 and Follow-up Visit