The Role of the Upper Colliculus in the Idiopathic Blepharospasm

The Role of the Upper Colliculus in the Idiopathic Blepharospasm : a Pilot Study in Functional MRI

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03903341

Acronym

COLL-BSP

Enrollment

Registered

2019-04-04

Start date

2019-11-20

Completion date

2021-11-19

Last updated

2022-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blepharospasm, Benign Essential

Keywords

Superior colliculus, fMRI

Brief summary

This pilot study aims at investigating the role of superior colliculus in patients with idiopathic blepharospasm (BSP) de novo, compared to healthy subjects.

Detailed description

The objective of the study is to investigate the function of the superior colliculus (SC) related to visual stimulation by means of fMRI (functional magnetic resonance imaging) in patients with idiopathic BSP compared to healthy subjects. The hypothesis is that SC function is impaired in BSP (role of biomarker of SC).

Interventions

OTHERfMRI

bold signal in visual pathway

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

30 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Non treated idiopathic blepharospasm * Age: 30- 70 years

Exclusion criteria

* Under the following treatments: Botulin toxin, anticholinergic, benzodiazepines, baclofen, beta- and alpha-blockers collyrium * No MRI Contraindication

Design outcomes

Primary

Measure	Time frame	Description
Visual pathways fMRI	In a five months period after inclusion	To measure the bold signal in superior colliculus and lateral geniculate corpus

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026