Recurrent Miscarriage
Conditions
Keywords
recurrent miscarriage, prednisolone treatment
Brief summary
This study aims to investigate the role of uNK cells and the association with prednisolone.
Detailed description
Glucocorticoids prednisolone is considered as a potential therapy in women with recurrent miscarriage. However, the evidence for treatment with prednisolone is still inconclusive and the relevant mechanism merits further investigations. The participants will be invited to take prednisolone oral 10 mg/day and attend our outpaitent clinic to be performed endometrial biopsy.
Interventions
DRUGPrednisolone
prednisolone oral 10 mg/day from day one of the subsequent menstrual cycle to day LH 7 of that cycle. Then, the participants will be given a tailing off dose of 5 mg/day for 3 days followed by 2 mg/day for 3 days and then 1 mg/day for 3 days.
Sponsors
Chinese University of Hong Kong
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
The participants will be invited to take prednisolone oral 10 mg/day and attend our outpaitent clinic to be performed endometrial biopsy.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Women with a history of 3 or more consecutive miscarriages 2. Women younger than 40 years old
Exclusion criteria
1. Allergy to prednisolone 2. Women who have any uterine anomaly 3. Antiphospholipid syndrome 4. Hydrosalpinx 5. Thrombophilia 6. Abnormal thyroid function tests 7. women with diabetes,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the number of uNK cells | at the 1 day of endometrial biopsy | to investigate the association between uNK cells and prednisolone |
Countries
Hong Kong
Contacts
Primary ContactStacey Wong, BSc
Backup ContactPui Wah Jacqueline Chung, MBBS
Outcome results
None listed