Healthy
Conditions
Brief summary
The scope of the study is to investigate the physiological response to salbutamol and exercise. A particular focus is on the metabolic response and amine metabolism.
Interventions
DRUGsalbutamol
subjects ingest salbutamol
OTHERexercise
subjects undergo 6 weeks of endurance training (3 times weekly)
Sponsors
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * VO2max of \>55 ml/min/kg for men and \>50 ml/min/kg for women * Body mass index (BMI) \< 26
Exclusion criteria
* Chronic use of beta2-agonist or allergy towards beta2-agonist * Serious adverse effects to beta2-agonist * Chronic disease deemed by the study responsible medical doctor to interfere with any part of the study * Smoking * Chronic use of prescription medicine deemed by the study responsible medical doctor to interfere with any part of the study * Pregnancy (for women)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body composition | Baseline, 2 weeks, 4 weeks and 6 weeks | Change in body composition (measured by dual energy x ray absorptiometry) |
| Maximal oxygen consumption (VO2max) | Baseline, 2 weeks, 4 weeks and 6 weeks | Change in VO2max (measured during bike ergometer cycling to exhaustion) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Salbutamol urine concentration | Before (baseline) as well as 0-1 hours, 1-2 hours, 2-4 hours, 4-8 hours, and 8-16 hours after administration | Concentration of salbutamol in urine |
Other
| Measure | Time frame | Description |
|---|---|---|
| Muscle strength | Baseline, 2 weeks, 4 weeks and 6 weeks | Isometric muscle force of the quadriceps |
Countries
Denmark
Outcome results
None listed