Bronchoscopy, Conscious Sedation, Fentanyl, Narcotrend, Remifentanil, Sufentanil
Conditions
Brief summary
The best opioid for bronchoscopy is still unclear.This randomized double-blind prospective study was conducted on a total of 60 patients who were randomly allocated into 3 groups: Group S received sufentanil 0.1 mcg/kg, Group F received fentanyl 1 mcg/kg and Group R received remifentanil target-controlled infusion with effect-site target concentration of 1ng/ml. Patients in all groups received midazolam to achieve moderate levels of sedation as assessed by the Narcotrend (NT; between B1 and C2). Adverse events, patient tolerance and physician satisfaction were analized.
Interventions
DRUGSufentanil
Patients in Group S received sufentanil 0.1 mcg/kg.
DRUGFentanyl
Patients in Group F received fentanyl 1 mcg/kg.
DRUGRemifentanil
Patients in Group R received remifentanil target-controlled infusion with effect-site target concentration of 1ng/ml.
DRUGMidazolam
Patients in all groups received midazolam to achieve moderate levels of sedation as assessed by the Narcotrend (NT; between B1 and C2).
Sponsors
Guangzhou Institute of Respiratory Disease
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* ASA grade I-II
Exclusion criteria
1. psychological disorders 2. SpO2\<90% in ambient air 3. hypersensitivity or allergy to anaesthetic drugs or benzodiazepine 4. severe chronic obstructive pulmonary disease (forced expiratory volume in 1 s ,50% of predicted value, requirement for oxygen therapy) 5. unstable haemodynamic status 6. habitual alcohol consumption 7. asthmatic patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dosage of midazolam | during the procedure | Dosage of midazolam applied |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| severity of cough | during the procedure | total times of cough |
| patient's subjective tolerance | 30minutes after bronchoscopy | the intensity of four key symptoms during bronchoscopy (pain, nausea, breathlessness and cough) and memory using a visual analogic scale (VAS: 1 mm: excellent tolerance, 100 mm very low tolerance) |
| patient's global tolerance assessed by operator | 30minutes after bronchoscopy | the global tolerance of patient to the procedure using a visual analogic scale (VAS: 1 mm: excellent tolerance, 100 mm very low tolerance) |
| rate of oxygen desaturation | during the procedure | oxygen desaturation (SaO2 decrease\<90% for \>30 s) |
Countries
China
Outcome results
None listed