Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease, Sarcoidosis
Conditions
Keywords
Laser Induced Breakdown Spectroscopy, Multi elemental imaging
Brief summary
Evaluate the feasibility of performing a multi-elemental imaging analysis of lung specimens from patients with ILDs, with an technology named LIBS (Laser Induced-Breakdown Spectroscopy)
Detailed description
There is a major health problem due to the environmental and occupational related exposures to mineral particles, metals, and dust. The impact on health is considerable in terms of prevalence, morbidity and healthcare costs. Pathologists rarely report the presence of a possible mineral or metal-related etiology in a specimen by lack of available and convenient technology. Therefore, several respiratory diseases are considered idiopathic. Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD) is a group of lung diseases affecting the interstitium (the tissue and space around the air sacs of the lungs). In France, 15.000 new cases of ILD are diagnosed each year. ILD may be classified according to the cause. Idiopathic ILD are ILD of unknown causes. The most frequent idiopathic ILD are sarcoidosis and idiopathic pulmonary fibrosis (IPF).These two diseases are the core topic of the present study since they may relate to important mineral or metal exposure. The overall goal of this MEDICO-LIBS study is to evaluate the feasibility of using a laser-induced breakdown spectroscopy (LIBS)-based instrument to image(ie, identify, localize and possibly quantify) metals within selected human specimens with ILDs.
Interventions
DIAGNOSTIC_TESTElemental analysis
LIBS multi elemental analysis of the specimen
Sponsors
University Hospital, Grenoble
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with ILD * Patient informed, and agreed to participate
Exclusion criteria
* Patient opposed to participating in the study. * Patient without available specimen. * Patient under legal protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Generation of multi-elemental images in tissues with LIBS | Within a month after reception of the biopsy by the analytical laboratory | Evaluation of the feasibility of collecting and describing LIBS multi-elemental images of lung specimens originating from patients with ILDs |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Description of elemental distribution in the specimens | Within a month after reception of the biopsy by the analytical laboratory | Comprehensive chemical characterization of both endogenous and exogenous elements for each specimen |
| Interpretation of the elemental maps | Within a month after reception of the biopsy by the analytical laboratory | Understanding of the elemental distribution according to the clinical data |
| Comparison of the elemental distributions with results of other mineralogical investigations | Within a month after reception of the biopsy by the analytical laboratory | Only for patients who previously benefited from other mineralogical investigations (eg, SEM-EDX), comparison of mineralogical analysis obtained with the elemental distributions obtained with LIBS |
Countries
France
Outcome results
None listed