Intrabony Periodontal Defect
Conditions
Keywords
Injectable platelet rich fibrin, I-PRF, Demineralized Freeze-Dried Bone Allograft, DFDBA, Stage 3 periodontitis, 3 wall intraosseous defect, 2 wall intraosseous defect
Brief summary
Clinical and radiographic evaluation of injectable platelet rich fibrin (i-PRF) and demineralized freeze-dried bone allograft (DFDBA) compared to demineralized freeze-dried bone allograft (DFDBA) alone in management of intraosseous defects in stage III periodontitis patients.
Detailed description
Intraosseous defects are defined by the apical location of the periodontal pocket to the alveolar crest. In a recent radiographic study employing cone-beam computed tomography, a high prevalence of intraosseous defects 83% has been reported. Treatment of intraosseous defects is clinically challenging, as they often require complex regenerative periodontal therapy. Current regenerative techniques often employed in treatment of intraosseous defects demonstrate variation in improvement of clinical outcomes and degree of periodontal regeneration achieved.
Interventions
PROCEDUREInjectable platelet rich fibrin combined with DFDBA
The i-PRF will be mixed with bone graft then will be placed into the intraosseous defect
PROCEDUREDemineralized Freeze Dried Bone Allograft
Demineralized Freeze Dried Bone Allograft alone will be placed into the intraosseous defect
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Due to the type of intervention, only the outcome assessor and the statistician will be blinded.
Eligibility
Sex/Gender
ALL
Age
25 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1. Type III periodontitis patient having at least one tooth with 2-wall, 3-wall, or combined 2- to 3-wall intraosseous defect ≥ 3 mm in depth (assessed by bone sounding, radiographic examination) with clinical attachment level ≥ 5 mm and pocket depth ≥ 6 mm. 2. Defect not extending to a root furcation area 3. Vital teeth 4. Non-smokers. 5. No history of intake of antibiotics or other medications affecting the periodontium in the previous 6 months. 6. No periodontal therapy carried out in the past 6 months. 7. Able to sign an informed consent form. 8. Patients age between 25 and 50 years old. 9. Patients who are cooperative, motivated, and hygiene conscious. 10. Systemically free according to Cornell Medical Index
Exclusion criteria
1. Pregnancy or breast feeding 2. The presence of an orthodontic appliance 3. Teeth mobility greater than grade I
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical attachment level gain (CAL) | CAL will be measured at base line, 3, 6, and 9 months postoperative | CAL will be measured from the cemento-enamel junction to the bottom of the gingival sulcus/periodontal pocket using the University of North Carolina periodontal probe at six sites per tooth. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Probing Depth (PD) | PD will be measured at base line, 3, 6, and 9 months postoperative | PD will be measured from the gingival margin to the bottom of the gingival sulcus/ periodontal pocket using the University of North Carolina periodontal probe at six sites per tooth. |
| Radiographic defect fill (IBD) | Radiographic defect fill will be measured at base line, 6, and 9 months postoperative | The depth of intrabony defect will be measured from the alveolar bone crest to the base of the defect at baseline, six months and after nine months to detect the amount of bone fill Individually customized bite blocks and parallel-angle technique will be used to obtain standardized radiograph. Radiographs will be scanned and the radiographic defect fill depth will be measured by a computer-aided software program |
| Gingival Recession Depth (RD) | RD will be measured at base line, 3, 6, and 9 months postoperative | RD will be measured from the cemento-enamel junction to the most apical extension of the gingival margin using the University of North Carolina periodontal probe at six sites per tooth. |
| Post-surgical patient satisfaction | After 9 months postoperative | A 3-item questionnaire will be asked to the patients and shall use a 7-points answer scale. These items will be: Would you experience the same surgery another time? Would you advice others with the surgery? To what extent are you satisfied with the results? 7 points mean the best 1 means the worst |
Countries
Egypt
Outcome results
None listed