Postprandial Hyperglycemia
Conditions
Brief summary
The amylose-amylopectin ratio influences starch properties. A higher amylose content is associated with slower starch digestion thus reducing the postprandial plasma glucose response and improving the overall postprandial metabolism. So far, limited evidence is available on the metabolic effect of wheat-based foods rich in amylose. This randomised controlled study investigated the acute metabolic effects of amylose-rich wheat-based breads in overweight subjects focusing on potential mechanisms.
Interventions
OTHERTest meal
Participants received in random order the three test meal (700Kcal, 80g available carbohydrates) containing breads prepared with amylose-rich wheat flours (70% or 85%) or conventional flour. Blood samples were collected at fasting and every 30 minutes over 4 hours. Breath hydrogen was evaluated as a marker of intestinal fermentation. Participants underwent Visual Analogue Scale to assess subjective appetite sensations. After 4 hours, all participants consumed a standard lunch (700 kcal, 100 g available carbohydrates) identical on all the three experimental days to evaluate the second meal effect from breakfast to lunch.
Sponsors
Federico II University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Overweight/obese * 18-70 years
Exclusion criteria
* age \<18 and \>70 years; * fasting triglycerides ≥400 mg/dl; * fasting cholesterol \>270 mg/dl; * cardiovascular events (myocardial infarction or stroke) during the 6 months prior to the study * established diabetes mellitus or any chronic disease * renal and liver failure (creatinine \>1.7 mg/dl and transaminases \>2 times than normal values, respectively) * anaemia (Hb \<12 g /dl)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 2-hours blood glucose response | over 2 hours after the test meal | incremental area under the curve |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 2-hours blood insulin response | over 2 hours after the test meal | incremental area under the curve |
| 4-hours blood glucose response | over 4 hours after the test meal | incremental area under the curve |
| 4-hours blood insulin response | over 4 hours after the test meal | incremental area under the curve |
| intestinal fermentation | over 4 hours after the test meal | breath test for the detection of hydrogen production |
| glucose response | over 2 hours after the standard meal | Second meal effect |
Countries
Italy
Outcome results
None listed