Eye Diseases, Uvea--Diseases, Uveitis, Uveitis Drug-Induced
Conditions
Keywords
Uvea toxicity, chemotherapies, drugs
Brief summary
Several drugs and chemotherapies seem to induce uveitis. This study investigates reports of uveitis, including the International classification of disease ICD-10 for treatments in the World Health Organization (WHO) global Individual Case Safety Report (ICSR) database (VigiBase).
Detailed description
Several drugs and chemotherapies seem to have an impact on the eyes and are responsible of uveitis. Those are poorly described, due to the modification of the pharmacopeia, and the recent recognition of several of these adverse events. This study investigates the main characteristics of patients affected by uveitis side effect imputed to drugs. A causality assessment according to the WHO-UMC (World Health Organization - Uppsala Monitoring Center) is systematically applied.
Interventions
DRUGDrugs inducing uveitis
Drugs susceptible to induce uveitis
Sponsors
Groupe Hospitalier Pitie-Salpetriere
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Case reported in the WHO's pharmacovigilance database till 01/04/2019
Exclusion criteria
* Chronology not compatible between the drug and the toxicity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Eye toxicities of drugs Identification and report of cases of uevitis associated with drugs | to 01/04/2019 | Case reported in the World Health Organization (WHO) database of individual safety case reports |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All relevants statisticals associations between type of uveitis and the category of drug | to 01/04/2019 | Case reported in the World Health Organization (WHO) database of individual safety case reports |
| All relevants statisticals associations between other concomittants immune related adverse events and uveitis induced by drugs | to 01/04/2019 | Case reported in the World Health Organization (WHO) database of individual safety case reports |
| Duration of treatment when uveitis happen (role of cumulative dose) | to 01/04/2019 | Case reported in the World Health Organization (WHO) database of individual safety case reports |
| Causality assessment of reported uveitis according to the WHO system | to 01/04/2019 | Case reported in the World Health Organization (WHO) database of individual safety case reports |
| All relevants statisticals associations between pathologies (cancer) for which the incriminated drugs have been prescribed, and occurence of uveitis | to 01/04/2019 | Case reported in the World Health Organization (WHO) database of individual safety case reports |
| All relevants statisticals associations between characteristics of the population and occurence of uveitis adverse event | to 01/04/2019 | Case reported in the World Health Organization (WHO) database of individual safety case reports |
| All relevants statisticals associations between drug-drug interactions and adverse events | to 01/04/2019 | Case reported in the World Health Organization (WHO) database of individual safety case reports |
Countries
France
Outcome results
None listed