Schizophrenia
Conditions
Keywords
Electroencephalography, Cognitive training, Physical training, Resting state networks
Brief summary
Neurophysilogical, neuropsychological evaluation and cognitive and physical training
Detailed description
24 sessions (8 weeks, 3 times per week) of cognitive and physical training via computer. Each session consisted of 45 minutes of cognitive traing (BrainHQ platform https://www.brainhq.com/) and 45 minutes of physical training (FitForAll platform https://www.fitforall.gr/play/app/). Cognitive training included memory, attention, velocity, intelligence etc. Physical training included aerobic, strength flexibility and other excercises. All evaluations were performed 1-14 before the initiation of the interventions and 1-14 after their completion. Neurophysiological evaluation consisted of EEG with the use of 128 electrode-machine and the protocol included 5 minuted of eyes closed and 5 minutes of eyes open. Neuropsychological evaluation included Trail Making Test (A & B), Verbal Fluency, Stroop test, Wechsler Memory - Cubes (visuospatial), MoCA, FAB (Screening for frontal damage) and Eyes Test (Theory of Mind). Also, the physical condition evaluation included 6-Minute Walking Distance (6MWD), ΒΜΙ, HandGrip Strength Test, Short Physical Performance Battery Protocol.
Interventions
OTHERCognitive Training
Cognitive training included memory, attention, velocity, intelligence
OTHERPhysical Training
Physical training included aerobic, strength, flexibility and balance.
Sponsors
Aristotle University Of Thessaloniki
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* a diagnosis of schizophrenia disorder according to ICD10 criteria * clinically stable patients (no recent change in psychotropic medication except benzodiazepines) * sufficient acculturation and fluency in Greek language * assent of the attending physician for participation in the study
Exclusion criteria
* co-morbidity with neurological disorders (e.g.epilepsy) or head injury * a pathological or other somatic disorder that contraindicate physical exercise * alcoholism and substance abuse within the previous 3 months (except caffeine and tobacco) * abstainance from intervention for more than 12 days * cognitive decline * treated with Benzodiazepine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Alterations in functional connectivity properties and on the organization of resting state networks | 3 months | Alterations in functional connectivity properties and on the organization of resting state networks quantified through graph theory tools. These measures would be measured through high-density electroencephalographic (EEG) evaluation and reconstruction of cortical activity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Reaction time | 2 months | Estimated through Stroop test |
| Generic cogntive impairment | 2 months | Estimated through Montreal Cognitive Assessment (MoCA) test |
| Theory of mind | 2 months | Estimated through Eye's test |
| Verbal fluency | 2 months | Estimated through Verbal Fluency test |
| Visual attention and task switching | 2 months | Estimated through Trail Making A & B test |
| Executive function | 2 months | Estimated through FAB (Frontalassesment test) |
| Depressive syndromes | 2 months | Estimated through Had's test |
| Physical fitness | 2 months | Estimated through 6-Minute Walking Distance (6MWD) |
| Memory | 2 months | Estimated through Wechsler Memory - Cubes (visuospatial) test |
Countries
Greece
Outcome results
None listed