Coronary Disease
Conditions
Keywords
trimethylamine-N-oxide
Brief summary
The primary aim of the current research project is to determine whether the TMAO concentration in the blood can serve as a prognostic indicator of myocardial infarction. The hypothesis is that in patients with recent myocardial infarction, TMAO concentration in blood is higher than in patients undergoing scheduled coronarography.
Detailed description
To the study will be included volunteers - patients with stable angina (SA), who were scheduled for conventional coronary angiography, and patients with acute coronary syndrome (ACS) who were admitted to the hospital with chest pain and undergoing coronography surgery. Blood samples will be taken from volunteers once - before the coronography surgery by qualified medical personnel.
Interventions
DIAGNOSTIC_TESTplasma samples collection
Trimethylamine N-oxide (TMAO) concentration will be determined in plasma samples
Sponsors
Gdansk University of Physical Education and Sport
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* diagnosed stable angina (SA) or acute coronary syndrome (ACS) and planned coronography
Exclusion criteria
* unconscious patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Trimethylamine-N-oxidec(TMAO) blood concentration | Immediately before coronography. | TMAO concentration determined by the ultra-performance liquid-chromatography tandem mass spektrometry (UPLC-MS/MS). |
Countries
Poland
Outcome results
None listed