Oligospermia
Conditions
Brief summary
In this study we aim to investigate whether a 3-month life-style intervention would reduce oxidative stress (OS) in semen in men of infertile couples attending IVF-treatment. Men with a DFI above 15% (SCSA method) are recruited for intervention with a 3-month follow-up. It is hypothesized that men who also have a OS above 1.34 using a novel OS diagnostic method (MiOXSYS) respond better to antioxidant treatment with a change in OS and DFI. The primary outcome is the change in OS following the intervention. Secondary outcomes are morphological semen parameters and DNA fragmentation index.
Interventions
DIETARY_SUPPLEMENTOmega 3
Omega 3: 1g daily for 3 months CoQ10: 100 mg daily for 3 months Multivitamin: 1 normal multivitamin tablet daily for 3 months
Sponsors
Peter Humaidan
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
All men with DFI \>15 (SCSA method) are assigned to life-style intervention.
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* DFI\>15 * Attending IVF treatment for unknown or male factor infertility.
Exclusion criteria
* Genetic diseases * Azospermia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxidative stress | 3 months | Oxidative stress as measured with MiOxysis (Ayto Bioscience inc). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Semen quality | 3 months | Morphological semen parameters using WHO recommendation for semen analysis. |
| DNA fragmentation index | 3 months | DNA fragmentation index as measured by the method by SPZlab A/S (SCSA method) |
Countries
Denmark
Outcome results
None listed