Effectiveness of Transcranial Direct Current Stimulation for TKR

Effectiveness of Transcranial Direct Current Stimulation for Postoperative Pain in Total Knee Replacement Surgery

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03898245

Enrollment

Registered

2019-04-01

Start date

2019-05-01

Completion date

2020-05-10

Last updated

2019-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Pain, Transcranial Direct Current Stimulation

Brief summary

Transcranial direct current stimulation (tDCS) is a technique of noninvasive cortical stimulation allowing significant modification of brain function used. Clinical application of this technique could be helpful for pain, Parkinson's disease, dystonia, cerebral palsy and dementia etc. And tDCS is safe with only mild, transient adverse effects. But there is few studies focused to postoperative states. The aim of this project is to reveal the effect of tDCS for postoperative pain after total knee replacement surgery,

Interventions

DEVICEapply tDCS

Intensity 2mA, 20minues, 4 times (post operation in 30min, in 4hrs, next day morning and next day afternoon) anodal tDCS applied over the left DLPFC cathodal tDCS applied over the right DLPFC

DEVICESham tDCS

Intensity 0mA, 40 seconds, 4 times (post operation in 30min, in 4hrs, next day morning and next day afternoon) anodal tDCS applied over the left DLPFC cathodal tDCS applied over the right DLPFC

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Subjects who have scheduled elective spine surgery.

Exclusion criteria

* Who has Cognitive dysfunction before surgery. * Who already has delirium before surgery. * Who has pain disorder ( like CRPS) * Who cannot reveal the one's pain.

Design outcomes

Primary

Measure	Time frame	Description
VAS score	1hour, 6hours, 24 hours, 48 hours	the decrease of pain scale in postop state with Visual Analog Scale.

Secondary

Measure	Time frame	Description
Incidence of Delirium	postop day 1,3,6	Incidence of Delirium
Consumption of PCA	24 hours	The consumption of opioid.

Countries

South Korea

Contacts

Primary ContactJin-Young Hwang, MD, phD

mistyblue15@naver.com+82-10-2746-4750

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026