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Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects

Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03897855
Acronym
I-TSPT-R
Enrollment
20
Registered
2019-04-01
Start date
2019-04-01
Completion date
2021-03-26
Last updated
2021-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-Traumatic Stress Disorder in Old Age

Brief summary

In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested. This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment. The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.

Interventions

OTHERPost Traumatic Stress Disorder

The test Think / No-Think

Sponsors

Centre Hospitalier de Niort
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
65 Years to 85 Years
Healthy volunteers
No

Inclusion criteria

\- Regarding the constitution of the group patient (TSPT-R): * Subjects 65 years of age or older * Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years * The traumatic event must have taken place at the latest before 65 years * Affiliated person or beneficiary of a social security scheme. * Written consent before any examination required by research) Regarding the constitution of the control group: * Subjects 65 years of age or older * No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not) * Affiliated person or beneficiary of a social security scheme. * Written consent before any examination required by the research).

Exclusion criteria

* For both groups: * Acute or chronic cognitive impairment known * GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely: * 22 if no diploma * 23 if certificate of study * 25 if patent * 26 if bin or more * Remove one point at each threshold if age\> 80 years * Sensory or motor disorder preventing the passing of different tests * Psychotic disorder * Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11) * Disorder of the use of a moderate or severe substance (except tobacco). * Patients under guardianship or curatorship.

Design outcomes

Primary

MeasureTime frameDescription
Inhibition score measured by the Think / No-Think Test1 monththe average of the inhibition score measured by the Think / No-Think test as defined by Anderson and Green (2001) and then reviewed by Anderson et al. in 2011

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026