Acute Kidney Injury, Chemotherapy
Conditions
Brief summary
Patients undergoing cytoreductive surgery with hyperthermic intraoperative chemotherapy (CRS with HIPEC) are prone to postoperative kidney dysfunction. Previous models predicting kidney injury after CRS with HIPEC did not include intraoperative physiologic data. This study is designed to include not only mean arterial pressure but other parameters such as systolic, diastolic arterial pressure, heart rate, oxygen saturation, body temperature, cardiac index, stroke volume variation and many other physical parameters using a data collection system that can record them every 1-7 seconds. The data will be analyzed using machine learning algorithms.
Interventions
OTHERData collection
This study is an observational study collecting perioperative data. There is no intervention regarding this study.
Sponsors
Gangnam Severance Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing cytoreductive surgery with hyperthermic intraoperative chemotherapy
Exclusion criteria
* patients under 19
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of patients with postoperative acute kidney injury staged by Kidney Disease: Improving Global Outcomes (KDIGO) | during postoperative day 7 | Stage 1: Increased sCr × 1.5 to 1.9 baseline or ≥ 0.3 mg/dl from baseline or urine output \< 0.5 ml/kg/h for 6 to 12 h, Stage 2: Increased sCr × 2.0 to 2.9 baseline or urine output \< 0.5 ml/kg/h for 12 h, Stage 3: Increased sCr × 3 baseline or ≥ 4 mg/dl or initiation of RRT, or GFR decrease \< 35 ml/min/1.73 m2 for patients \< 18 years of age or urine output \< 0.3 ml/kg/h for 24 h or anuria for 12 h |
Countries
South Korea
Outcome results
None listed