Normal Healthy Volunteers Without Chronic Medical Conditions
Conditions
Brief summary
To establish quantitative values of myocardial blood flow (MBF) in normal, healthy volunteers .
Detailed description
We seek to establish quantitative values of myocardial blood flow in 20 normal, healthy volunteers using our existing 2D PET camera (Positron Attrius) and invasively validated software package (HeartSee) in order to 1) establish institutional values for which clinical patients can be compared to and 2) add to the collective data of the scientific community. Values to be measured will be resting myocardial blood flow (MBF), stress MBF and coronary flow reserve.
Interventions
PROCEDUREcardiac PET stress test
Volunteers will undergo cardiac PET stress testing
Sponsors
Ochsner Health System
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults ≥18 and \<40 years old * Participants must be able to give informed consent. * Ability to abstain from caffeine for 48 hours
Exclusion criteria
* Any chronic cardiac disease or condition (e.g. hypertension, hyperlipidemia) * Any chronic systemic disease or condition (e.g. diabetes, systemic lupus, rheumatoid arthritis) * Tobacco use * Family history in a first degree relative with clinical coronary artery disease (history of myocardial infarctio, percutaneous intervention or coronary artery bypass grafting) in men \<55 years old or women \<65 years old * Severe claustrophobia * Positive urine pregnancy test * Inability to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Absolute myocardial blood flow at rest and stress in cc/min/g | measured at the time of the cardiac PET stress scan | resting and stress MBF are in units of cc/min/g |
Countries
United States
Contacts
Primary ContactRobert M Bober, MD
Backup ContactHunter McDaniel
Outcome results
None listed