Predictive Factors of Autonomy Loss in Real-life Cohort

Predictive Factors Associated With Impairment in Functional Autonomy in a Regional Real-life Cohort of Patients With Alzheimer's Disease or Related Disorders (ADRD)

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03894254

Acronym

MEM-AURA

Enrollment

5400

Registered

2019-03-28

Start date

2020-09-09

Completion date

2032-03-01

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Memory Disorders

Brief summary

The Alzheimer's disease or related disorders (ADRD) are among the most disabling diseases because of their main features such as cognitive impairment, loss of functional autonomy and behavioural disorders. In absence of current curative treatment, the identification of the predictive risk factors of progression of the disease, evaluated through its main symptoms, represents a major stake of public health. The Investigators aim at developing a regional database, which includes the patient medical records on a prospective basis, in collaboration with the medical and administrative staff and with the University hospital computer science departments. The main objective is to study the predictive factors associated with change in functional autonomy level, measured every 6 to 12 months in centres across Region Auvergne Rhone-Alpes in France. The real-life study population will consist in about 5400 patients with ADRD. The inclusion period will be of 3 years, the length of follow-up of each patient will be of 10 years max for a total study length of 13 years.

Interventions

OTHERno intervention

This is study carried out in current practice. Patients are undergoing a medical examination in a memory center, with extensive and systematic evaluations for the study involving the following tests: IADL, DAD6, New AGGIR, NPI, and mini-Zarit) assessing the functions (autonomy, behavior and caregiver burden).

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients aged 18 years and older, undergoing a medical visit in a memory center or neuro-cognition service * Patients living at home or in housing * Patients with memory impairment, at all stage of the disease

Exclusion criteria

* Patients in institution * Patients under legal protection * Patients with a hearing or visual impairment, which prevents carrying out examinations

Design outcomes

Primary

Measure	Time frame	Description
Functional autonomy level	from 6 months to 12 months interval	The Lawton Instrumental Activities of Daily Living (IADL)

Countries

France

Contacts

Primary ContactPierre Krolak-Salmon, PhD

pierre.krolak-salmon@chu-lyon.fr04 72 43 20 50

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026