Dilated Cardiomyopathy, Heart Failure
Conditions
Keywords
heart Failure, ventricular elastance, dilated cardiomyopathy, right heart systolic function, right ventriculo-arterial coupling
Brief summary
We examined the feasibility and reliability of a combined echocardiographic and right heart catheterization (RHC) approach for right ventriculo/arterial (R-V/A) coupling assessment in HF patients with dilated cardiomyopathy (D-CMP).
Detailed description
This is a single center, retrospective cross-sectional study. In 2016-17, for 6 months, we evaluated for eligibility 81 consecutive D-CMP patients afferent to Niguarda Great Metropolitan Hospital for RHC and echocardiography. All participants underwent the exams in the context of heart-transplant or advanced HF evaluation. Inclusion criteria were: 18 years old, given informed consent, D-CMP, New York Heart Association (NYHA) functional class II or III and reduced EF (≤ 35%). On the contrary, exclusion criteria were: missing the inclusion criteria and refused informed consent. The final sample consisted of 68 study participants (mean age 64±7 years, 82 % male).
Interventions
DIAGNOSTIC_TESTVentriculo-arterial coupling assessment (R-V/A)
R-V/A was achieved by computing the R-Elv/P-Ea ratio (Right ventricular elastance/Pulmonary arterial elastance). R-Elv was computed as PAPm / end-systolic area (ESA) of the right ventricle. P-Ea was obtained as (PAPm-PCWP)/ right ventricle stroke volume (R-SV).
Sponsors
ITAB - Institute for Advanced Biomedical Technologies
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years old * Given informed consent * D-CMP * New York Heart Association (NYHA) functional class II or III * Reduced EF (≤ 35%)
Exclusion criteria
* Missing the inclusion criteria * Refused informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with altered Right ventriculo/arterial (R-V/A) coupling over PAPm and Pulmonary Hypertension types | up to 24 weeks | Significant correlations and augmentation over PAPm and Pulmonay Hypertension |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of agreement in Right ventriculo/arterial (R-V/A) coupling assessment | up to 24 weeks | Two independent physicians, both experts in echocardiography, independently re-examined 40 studies, randomly selected from all the acquired echocardiographic images. In order to test the R-V/A coupling interobserver agreement |
Countries
Italy
Outcome results
None listed