Circulatory Function in Laparoscopic Radical Cystectomy for Bladder Cancer

Preliminary Study on the Changes of Perioperative Circulatory Function in Patients Undergoing Laparoscopic Radical Cystectomy for Bladder Cancer

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03892031

Enrollment

186

Registered

2019-03-27

Start date

2018-01-01

Completion date

2019-12-31

Last updated

2022-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory Function, Laparoscopic Radical Cystectomy for Bladder Cancer

Keywords

brain natriuretic peptide, pneumoperitoneum, Trendelenburg, circulatory function, laparoscopic radical cystectomy for bladder cancer, central venous pressure, stroke volume variation, transthoracic echocardiography

Brief summary

To optimize the perioperative management of patients undergoing laparoscopic radical cystectomy(LPC) for bladder cancer through observation of perioperative changes of Brain Natriuretic Peptide(BNP), stroke volume variation(SVV), central venous pressure(CVP) and the use of transthoracic echocardiography(TTE).

Detailed description

Long term pneumoperitoneum and steep trendelenburg in LPC for bladder cancer influence perioperative circulatory function, resulting in a series of pathophysiological changes. BNP is of high sensitivity and specificity in the evaluation of cardiac function. SVV and CVP are dynamic and static indices to predict fluid responsiveness. TTE is a good indicator of volume and cardiac function.Thus, we conducted the trial to assess the perioperative circulatory function in patients undergoing LPC. We hypothesized that long term pneumoperitoneum and steep trendelenburg in LPC for bladder cancer would increase perioperative blood volume and influence cardiac function.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* undergoing laparoscopic radical cystectomy for bladder cancer * ASA I-II

Exclusion criteria

* Cardiac insufficiency * Hepatic insufficiency * Renal insufficiency

Design outcomes

Primary

Measure	Time frame	Description
Brain Natriuretic Peptide(BNP)	before induction (T1), at the end of operation(T2), at 12 hours (T3) and 24 hours (T4) postoperatively	To observe the change of BNP perioperatively.
Central Venous Pressure(CVP)	before induction (T1),at the end of operation (T2), at 12 hours (T3) and 24 hours (T4) postoperatively	To observe the change of CVP perioperatively.
Stroke Volume Variation(SVV)	before induction (T1), at the end of operation (T2)	To observe the change of SVV perioperatively.
Transthoracic Echocardiography	before induction (T1),at the end of operation (T2), at 12 hours (T3) and 24 hours (T4) postoperatively	To observe the change of End-diastolic volume(EDV) perioperatively

Countries

China

Outcome results