Preeclampsia
Conditions
Brief summary
100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index \[RI\], pulsatility index \[PI\] and systolic/diastolic \[S/D\] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes
Detailed description
100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index \[RI\], pulsatility index \[PI\] and systolic/diastolic \[S/D\] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes
Interventions
DRUGMgSO4
The magnesium sulfate will be given according to the regimen of 6 grams intravenous over 20 minutes as a loading dose.
Sponsors
Cairo University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Singleton pregnancy. * Primigravida or Multigravida. * Pregnant females ≥ 37 weeks of gestation. * Diagnosed as severe preeclampsia by the following criteria: * Sustained systolic blood pressure of ≥160 mmHg or a sustained diastolic blood pressure of ≥ 110 mmHg. * Proteinuria measured as +1 or more by dipstick or 24 hours urine collection with proteinuria ≥ 0.3 grams. * Oliguria or creatinine \> 1.1 mg%. * Laboratory findings characteristic of HELLP syndrome. * Symptoms suggestive of severe preeclampsia ; severe headache, blurring of vision, epigastric pain.
Exclusion criteria
* Multifetal pregnancy. * History of epilepsy. * Patients with diabetes. * Patients with renal disease. * Fetuses with congenital anomalies. * Patients receiving anticoagulants e.g. heparin (unfractionated or low molecular weight). * Patients with severe IUGR. * Patients with accidental hemorrhage.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in uterine artery resistance index | 15 minutes after the loading dose of MgSO4 | Doppler assessment of uterine artey RI |
Countries
Egypt
Contacts
Primary ContactAhmed Maged, MD
Backup ContactMohamed Elmahy, MD
Outcome results
None listed