Occupational Exposure
Conditions
Brief summary
Sevoflurane is a widely used volatile agent for induction and maintenance of anaesthesia. The administration of sevoflurane involves the risk of occupational exposure. Possible negative implications of chronic occupational exposure to sevoflurane are not completely refuted. In Germany no maximum workplace concentration for sevoflurane is defined. This study aims to find out if working conditions of physicians and different anaesthesia techniques effect the extent of occupational exposure to sevoflurane.
Detailed description
In this prospective observational trial 7 cohorts of 4 participants each are investigated. The cohorts consist of physicians working at different places in the operating theatre with different occupational exposure to sevoflurane, and one cohort not working in the operating theatre at all. In order to determine the extent of occupational exposure to sevoflurane a human biomonitoring is conducted. Urinary Sevoflurane and its metabolite hexafluoroisopropanol (HFIP) are measured after 3 consecutive working days. UPDATE: After detecting traces of HFIP in all cohorts even in physicians not working in the operating theatre measurements were repeated, more cohorts were added including a negative control and measurements before the study period of 3 consecutive working days were added. UPDATE: For comparison one cohort of patients having undergone sevoflurane anaesthesia was added.
Interventions
DIAGNOSTIC_TESTHFIP and Sevoflurane are measured after 3 consecutive days of work.
Concentration of hexafluoroisopropanol and Sevoflurane are measured in urine by gas chromatography
Sponsors
Universitätsklinikum Hamburg-Eppendorf
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Occupational exposure to sevoflurane while conducting sevoflurane anaesthesia/being present during sevoflurane anaesthesia * Possible occupational exposure to sevoflurane while working in the operating room/perioperative anaesthesia care unit * No occupational exposure to sevoflurane (working outside the operating theatre)
Exclusion criteria
* Presence during a mask induction with sevoflurane
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urinary HFIP concentration (µg/l) | After 3 consecutive days of work | After 3 consecutive days of work a urine sample is collected and urinary HFIP is measured by gas chromatography |
| Urinary sevoflurane concentration (µg/l) | After 3 consecutive days of work | After 3 consecutive days of work a urine sample is collected and urinary sevoflurane is measured by gas chromatography |
Countries
Germany
Outcome results
None listed