Infertility, Infertility, Female, Vitamin D3 Deficiency, Vitamin D Deficiency
Conditions
Keywords
vitamin D, vitamin D supplementation, infertility, D vitamin deficiency, infertile women, embryo transfer, pregnancy rate
Brief summary
Objective: To examine the effect of vitamin D supplements on the pregnancy and clinical pregnancy rate in embryo transfer cycles. Design: Experimental study with a pre- and post-test. Setting: In Vitro Fertilization Center Patients: Its sample consisted of 118 women, 58 in the experimental group and 60 in the control group. Intervention(s): At the beginning of the infertility treatment, the experimental group took vitamin D supplements, and the control group did not. Vitamin D supplementation for infertile women includes regulation of a diet rich in vitamin D, educational and motivational interviews about insolation, and taking vitamin D orally. Main Outcome Measure(s): 25(OH)D and beta HCG levels
Interventions
DRUGDEVIT-3
The physicians gave the women in the experimental group vitamin D oral drops in an ampoule of 300,000 IU and a vial of 50,000 IU to take during the IVF treatment. Written and verbal information about how to take vitamin D was provided to the participants by the nurses. The women took 300,000 IU vitamin D orally for the first week. In the second week of the treatment, 50,000 IU vitamin D (15 drops/day) was used as maintenance dose until the pregnancy test day.
Sponsors
Akdeniz University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-45 years old * literate in Turkish * voluntary participation * primarily infertile * had undergone controlled ovarian hyperstimulation and had a fresh ET * vitamin D levels lower than 30ng/mL before infertility treatment
Exclusion criteria
* patients with uncorrected congenital or acquired uterine anomalies * bone, parathyroid gland, kidney and liver disorders * use of anticonvulsants/antacid drugs * taking dietary supplements contain vitamin D * secondary infertility
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Vitamin D level | The 25 (OH)D levels of the experimental group women were tested on the second or third day of their menstrual cycle. (Pretest) | The vitamin D blood test was measured by the level of 25(OH)D. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Biochemical pregnancy | HCG levels of the women were evaluated on the two weeks after embryo transfer (Post test) | The pregnancy test was measured level of HCG in the blood. |
Countries
Turkey (Türkiye)
Outcome results
None listed