Uveitis
Conditions
Brief summary
Optical Coherence Tomography (OCT) machines are non-contact instruments that can provide micrometer scale imaging of biological tissue. Applying the image processing allows us to automatically measure the choroidal thickness with good interclass correlation coefficient to the manual measurements.
Interventions
None listed
Sponsors
Wrocław University of Science and Technology
Wroclaw Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* To the control group - ability to perform OCT examination * To the uveitis group - with one or more of the following clinical features (as indicators for active state of the disease): 1. \>1+ anterior chamber cells; 2. \>1+ vitreous haze; 3. presence of vitreous cells; 4. presence of blood in anterior chamber; 5. presence of blood in vitreous; 6. presence of aqueous or vitreous pigment.
Exclusion criteria
* To the control group - diagnosed uveitis * In case of all groups: 1. inability to give informed consent; 2. inability to maintain stable fixation for OCT imaging.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Submacular choroidal thickness in different stages of the disease | 5 years | OCT EDI recordings processed with developed by researchers methodology for image processing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The SUN working group grading system for anterior chamber cells | 1 year | At each visit anterior chamber will be examined to assess anterior chamber cells (1mm x 1mm slit beam in height and width, when thrown at an angle of 45-60°). The recorded number of cells will be used to determine the grade according to the SUN criteria. |
| The SUN working group grading system for anterior chamber flare | 1 year | At each visit anterior chamber will be examined to assess anterior chamber flare (1mm x 1mm slit beam in height and width, when thrown at an angle of 45-60°). The observed changes will be used to determine the grade according to the SUN criteria. |
| ETDRS Visual Acuity | 1 year | Visual Acuity will be performed with ETDRS charts different for right and left eye |
| NIH grading system for vitreous cells | 1 year | At each visit vitreous will be examined to assess vitreous cells (1mm x 3mm slit beam in anterior vitreous). The recorded number of cells will be used to determine the grade according to the NIH criteria. |
| NIH grading system for vitreous haze | 1 year | At each visit vitreous will be examined to assess vitreous haze. The recorded of clarity of posterior pole funduscopy will be used to determine the grade according to the NIH criteria. |
| AREDS 2008 Clinical Lens Opacity Grading Procedure | 1 year | Using AREDS system for classifying cataracts from photographs: AREDS Report No. 4 the lens opacity will be graded |
Countries
Poland
Outcome results
None listed