Cataract, Primary Open-angle Glaucoma
Conditions
Keywords
Retinal nerve fiber layer (RNFL), Ganglion cell complex (GCC), Optical coherence tomography (OCT), Primary open angle glaucoma (POAG), Cataract
Brief summary
Optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) is done before and after cataract extraction in patients with or without primary open angle glaucoma (POAG)
Detailed description
The investigator's study includes two groups of patients, each consists of 25 eyes, group 1 (cataract group)includes patients who are planned for cataract extraction without any other preexisting retinal or optic nerve pathology that may affect the RNFL thickness, while group 2 (combined cataract and glaucoma group) includes patients who are diagnosed with POAG controlled on medical treatment with cataract and planned for cataract extraction only. The OCT scans with complete ophthalmological examination are done before surgery and 6 weeks after uneventful cataract extraction (phacoemulsification with intraocular lens implantation)
Interventions
DIAGNOSTIC_TESTOct scans
Oct scans to assess thickness of RNFL and GCC before and after cataract extraction surgery in both groups
Sponsors
Kasr El Aini Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
• patients with cataract without any other concomitant retinal, optic nerve head pathology other than POAG are included in the study and divided onto two groups
Exclusion criteria
* Patients having any retinal or optic nerve pathology that might have affected nerve fiber layer thickness other than POAG eg: high myopia * POAG patients who are planned for combined surgery * Refractive errors greater than spherical equivalent of 6 diopters (myopia or hypermetropia) * Dense cataract hindering OCT imaging * History of previous ocular surgery or trauma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| RNFL and GCC thickness | Oct scans before and 6 weeks after surgery | Assessment of RNFL and GCC thickness change after cataract extraction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Final best corrected visual acuity (BCVA) | Six weeks after cataract surgery | Assessment of the final BCVA recorded according to the Snellen chart and converted to logMAR for statistical analysis |
Other
| Measure | Time frame | Description |
|---|---|---|
| Intraocular pressure (IOP) change and central foveal thickness (CFT) change | Six weeks after cataract surgery | Assessment of the IOP and CFT change after cataract extraction |
Countries
Egypt
Outcome results
None listed