Perthes Disease in Norway

A Prospective Nationwide Study of Perthes' Disease in Norway: Functional and Radiographic Outcomes at a Mean Follow-up of Twenty Years

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03885960

Enrollment

216

Registered

2019-03-22

Start date

2018-11-01

Completion date

2025-12-31

Last updated

2025-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Legg Calve Perthes Disease

Keywords

Hip, function, quality of life, osteoarthritis, Perthes, LCPD

Brief summary

Calvé-Legg-Perthes disease (CLP) is a hip disease in children whose femoral head becomes completely or partially necrotic. The disease is most common in five-six years of age. The femoral head is gradually deformed during the active stages of the disease (5-7 years). By healing, the hip joint shape will vary from an approximately normal joint to pronounced changes, the hip joint will be irregular. Such a hip joint is available for osteoarthritis. The purpose of this study is to map the function of the hip, the patient's quality of life and especially the risk factors that affect the outcome of the previous CLP. A nationwide prospective study of CLP was conducted between 1996 and 2000. All children with newly diagnosed Perthes disease (425) were registered. The current study will follow up all these patients with an average follow-up of 20 years. Radiological endpoints are evidence of hip osteoarthritis. Patient-reported outcomes (PROMS) should illuminate the function of the hip and quality of life.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 40 Years

Healthy volunteers

Inclusion criteria

\- Subject was diagnosed with Perthes disease between 1996 and 2000 in Norway

Exclusion criteria

* Death upon follow up * Other skeletal dysplasia * Patient not able to give consent,

Design outcomes

Primary

Measure	Time frame	Description
Hip osteoarthritis	an average of 20 years follow-up	radiographic measurement of weight bearing zone
Hip function	an average of 20 years follow-up	PROMS HOOS

Secondary

Measure	Time frame	Description
Hip ROM	an average of 20 years follow-up	functional test of range of motion of the hip
Gluteal muscle strength	an average of 20 years follow-up	Trendelenburg test
Hip strength	an average of 20 years follow-up	single leg hop test - 6 meters

Countries

Norway

Outcome results