Autoimmune Diseases
Conditions
Brief summary
Cardiac involvements in autoimmune diseases (AD) is common but underestimated and an early detection remains a clinical challenge for lacking of efficient imaging methods. The objective of the study was to investigate LV myocardial abnormalities in AD patients by multimodal cardiac imaging, including speckle-tracking echocardiology (STE), cardiac magnetic resonance imaging (CMRI) and positron emission tomography (PET).
Interventions
None listed
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patient is diagnosed with autoimmune diseases, including systemic lupus erythematosus (SLE), vasculitis, dermatomyositis, sjogren's syndrome, scleroderma, rheumatoid arthritis and IgG4 associated disease. * Patient is capable of complying with study procedures
Exclusion criteria
* Patient is pregnant or nursing * Patient is complicated with congenital heart disease * Patient had cardiac surgery before * Patient is complicated with serious infections * Patient is complicated with organ failure * Patient is complicated with tumors * Patient is diagnosed indefinitely * Patient has been involved in other clinical trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in deformational parameters in echocardiography during follow-up period | 6 months - 1 year - 2 years | global longitudinal strain (%), circumferential strain (%) and radial strain (%) measured by STE in autoimmune diseases |
| Progression of myocardial fibrosis and edema during follow-up period | 1 year - 2 years | Late Gadolinium Enhanced, T1 mapping and T2 mapping tested by CMRI |
| Change in myocardial perfusion during follow-up period | 1 year - 2 years | SUVmax examined by PET |
Countries
China
Contacts
Primary ContactWei Chen, MD
Outcome results
None listed