Incidence and Risk of Influenza in Myasthenic Patients

Incidence and Risk of Influenza in Myasthenic Patients Hospitalized in Intensive Care

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03884777

Enrollment

400

Registered

2019-03-21

Start date

2009-01-01

Completion date

2017-12-31

Last updated

2019-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myasthenic Crisis, Upper Respiratory Infection

Keywords

Influenza A virus, myasthenia gravis, neurocritical care clinical, neuromuscular disease

Brief summary

Upper respiratory infection , including influenza, may exacerbate the symptoms of myasthenia gravis (MG), which is an autoimmune disease that causes muscle weakness and, in some cases, can precipitate a myasthenic crisis In the present study, we investigated the incidence and risk factors of influenza infection on in myasthenia gravis patients.

Detailed description

This is a descriptive study. The data will be analyzed retrospectively . Inclusion of 416 cases of influenza in myasthenic patients treated in the intensive care unit of Garches Hospital between January 1, 2009 and December 31, 2017. Patients who meet the inclusion and non inclusion criteria and do not object to participate in the study will be collected in a database for analysis.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Men or women over the age of 18. * Myasthenic patients hospitalized in intensive care. * Patients with confirmed influenza infection

Exclusion criteria

* Age \<18 years, * Other neuromuscular diseases, * Patient opposing the use of his data

Design outcomes

Primary

Measure	Time frame	Description
Incidence of influenza in myasthenic patient in crisis	between January 1, 2009 and December 31, 2017.	Number of influenza cases in myasthenic patients

Secondary

Measure	Time frame	Description
Risk factors for poor outcomes	between January 1, 2009 and December 31, 2017.	To identify risk factors for severe influenza in myasthenic patients

Outcome results