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Acute Myocardial Infarction: Prognostic and Therapeutic Evaluation

Acute Myocardial Infarction From Clinical Presentation to Strategy Treatment

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03883711
Acronym
AMIPE
Enrollment
11000
Registered
2019-03-21
Start date
2017-01-01
Completion date
2028-12-31
Last updated
2026-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Coronary Syndrome, Myocardium; Injury

Keywords

Acute coronary syndrome, Myocardial injury, ACS, MINOCA

Brief summary

AMIPE is both a retrospective and prospective study which was designed in order to collect data of patients with acute coronary syndromes and myocardial injury and to improve the knowledge about these conditions.

Detailed description

AMIPE is an observational, multicenter and both retrospective and prospective study enrolling a cohort of consecutive incident patients admitted to participating hospitals with a diagnosis of acute coronary syndrome or myocardial injury from 01/01/2016 to 31/12/2023. The aim of this study is to create a database including a comprehensive characterization of these patients in order to obtain new scientific evidence about these conditions. Informations about the patients will be gathered from in-hospital medical records. A written informed consent is needed for every prospective patients enrolled in the study, In particular, the main objectives of the study are: * document the characteristics of all patients presenting with acute coronary syndrome and myocardial injury; * document the long term outcome rates; * document the therapeutic regimens and investigation conformity of treatment with already established guidelines. Every diagnostic or therapeutic intervention will be in accordance with established guidelines and good clinical practice. Statistics will be conducted utilizing univariate and multivariate analysis for outcomes. In particular for what concerns univariate analysis, ordinal variables will be analysed with t-test and Mann-Whitney Test, whereas categorical responses with Fischer Exact Test and with Pearson Chi-square test. Multivariate analysis will be conducted with logistic regression for dichotomous variables, with mixed generalized linear model for ordinal or nominal variables and with ANOVA or MANOVA for continuous variables.

Interventions

Create a database containing clinical characteristic, clinical presentation, flow indexes and treatment of consecutive incident patients with ACS or myocardial injury.

Sponsors

IRCCS Azienda Ospedaliero-Universitaria di Bologna
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patient aged \> 18 years old * Acute coronary syndrome or myocardial injury * Written informed consent

Exclusion criteria

* under age or not able to give informed consent

Design outcomes

Primary

MeasureTime frameDescription
All cause mortality1 yearDeath rate
Major Adverse Cardiac Events (MACEs)1 yearMACEs rate

Secondary

MeasureTime frameDescription
Cardiovascular risk factors prevalence1 yearDifferences in percentage of patients with STEMI or NSTEMI, or type 1 or type 2 myocardial infarction with any risk factors
Differences in clinical presentation3 yearPrevalence of patients presenting with ST elevation, angina, dyspnea, atypical chest pain, cardiogenic shock, arrhytmias)
Difference diagnosis between myocardial infarction subtypes and between myocardial infarction and myocardial injury5 yearDifferences in clinical presentation (ST elevation, angina, dyspnea, atypical chest pain, cardiogenic shock, arrhytmias)
Differences in flow characteristics1 yearTIMI, TIMI frame count
Differences and impact of periprocedural ischemic complications5 yearType 4a myocardial infarction, periprocedural myocardial injury

Countries

Italy

Contacts

CONTACTCarmine Pizzi, Prof
carmine.pizzi@unibo.it0039 (0)512144933
PRINCIPAL_INVESTIGATORCarmine Pizzi, Dr

University of Bologna, Cardiology Department

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026