Immune Deficiency, Sepsis
Conditions
Brief summary
This is an observational study to evaluate the diagnostic and prognostic value of presepsin in the critically-ill immunocompromise patients.
Interventions
None listed
Sponsors
Jongmin Lee
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female aged ≥ 19 years * Appropriate clinical data to enable classification into sepsis * Written informed consent by the patient or legally authorized representative * Critical illness consistent with sepsis, to be enrolled within 24 hours of presentation
Exclusion criteria
* No informed consent * A patient who is judged to be unable to make a voluntary decision by understanding information about this research due to cognitive vulnerability
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Area Under the Receiver Operating Characteristic Curve (ROC-AUC) of the Plasma Presepsin Concentration for Discriminating Between immunocompetent and immunocompromised patients. | up to 7 days | For the analysis, plasma presepsin levels on Day 0 will be used. Sepsis was made on Day 7 or day of discharge. ROC-AUC of presepsin for discriminating between immunocompromised and immunocompetent patients is compared to that of procalcitonin. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| survival at ICU discharge or day 28 after enrollment | 28 days | For the analysis, we will evaluate the association between presepsin and survival at ICU discharge or day 28 after enrollment |
Countries
South Korea
Outcome results
None listed