HIV/AIDS
Conditions
Keywords
Exercise, Cognition, Body composition, Inflammatory biomarkers, CD4
Brief summary
The aim of this study will be to verify effects of resistance training in people living with HIV/AIDS.
Detailed description
The aim of this study was verify effects of resistance training in cognitive function, body composition and biochemical parameters of inflammation and oxidative stress in people living with HIV/AIDS. The sample was composed by patients with HIV/AIDS of both sexes. The patients were randomized in two groups, a exercise group (EG), which was receive intervention with eight weeks of resistance training, and a control group (CG), that was not to do exercise. The cognitive function was analyzed with Stroop Test and Trail Test; body composition was evaluated by bioimpedance; blood tests was use to analyze biochemical parameters of inflammation and oxidative stress. For statistical analysis was used ANOVA of two factors for repeated measurements, having the (EG and PG) group and the time (pre and post exercise). Level of significance adopted was P \< 0,05.
Interventions
OTHERExercise group
Resistance training 3 times per week (45-60 minutes of resistance training)
Sponsors
State University of Maringá
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Blood collections and subsequent analyzes were done blindly.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnostic for HIV/AIDS. * Clinical condition and viral count stabilized. * Have been using (HAART) for 6 months or more. * Not have participated in physical exercise programs in six months before beginning of study. * Not have muscle or joint injuries that make it impossible to practice physical activity. * Not be pregnant.
Exclusion criteria
* Not attending more than 15% of the intervention sessions or visits to the laboratory. * Aggravation of the disease. * Stick to a physical activity program in addition to that offered by the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Cognitive Function | Baseline and eight weeks | Victoria Stroop, Castro Cunha & Martins Stroop and Trail Test were performed at baseline and after eight weeks of intervention in both groups (EG and CG). Blood will be collected and brain-derived neurotrophic factor (BDNF) will be measured by Enzyme-Linked Immunosorbent Assay Method (Human - ELISA Kit) at baseline and after eight weeks of intervention in both groups (EG and CG). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| CD4 / CD8 | Baseline and eight weeks | Blood was collected and cluster of differentiation 4 (T CD4+) and cluster of differentiation 8 (T CD8+) cells was measured by flow cytometry (BD TrucountTM Tubes) with FACSCalibur (Dickinson, New Jersey, USA) at baseline and after eight weeks of intervention in both groups (EG and CG). |
| Concentration of Inflammatory markers | Baseline and eight weeks | Blood was collected and interferon (INF-y), interleukin 4 (IL-4), interleukin 6 (IL-6) and interleukin 10 (IL-10) was be measured by Enzyme-Linked Immunosorbent Assay Method (Human - ELISA Kit) at baseline and after eight weeks of intervention in both groups (EG and CG). |
| Health cellular | Baseline and eight weeks | Cellular health was evaluated through phase angle value using the bio-electrical bioimpedance method (Biodynamics 450 analyzer, Biodynamics Corporation, Seattle, USA) at baseline and after eight weeks of intervention in both groups (EG and CG). |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in handgrip strength | Baseline and eight weeks | Handgrip strength was evaluated by handgrip dynamometer at baseline and after eight weeks of intervention in both groups (EG and CG). |
| Change in body composition | Baseline and eight weeks | Body composition was evaluated at baseline and after eight weeks of intervention in both groups (EG and CG) using thickness of skin folds (Lange Adipometer). The skin folds of the triceps, subscapular, supra iliac, abdominal, thigh and leg were collected. The data were inserted into formulas appropriate to the population studied for calculating body composition. |
| Training load control | Baseline and eight weeks | Training load control was done by weekly monitoring and adjustment of the weights (kg) used in each exercise. |
| Change in flexibility | Baseline and eight weeks | Flexibility was evaluated by sit and reach test at baseline and after eight weeks of intervention in both groups (EG and CG). |
| Change in body circumferences | Baseline and eight weeks | Perimeters of arms, chest, abdomen, waist, hip, thigh and leg were measured at baseline and after eight weeks of intervention in both groups (EG and CG). |
| Change brachial blood pressure | Baseline and eight weeks | Brachial blood pressure (systolic and diastolic pressures) was assessed through an automatic monitor (HEM-742, Omron Healthcare, Japan) at baseline and after eight weeks of intervention in both groups (EG and CG). |
| Change autonomic cardiac modulation | Baseline and eight weeks | The autonomic cardiac modulation was evaluated through a heart rate monitor (Polar, model RS-800, USA) at baseline and after eight weeks of intervention in both groups (EG and CG). |
Countries
Brazil
Outcome results
None listed