The Difference in Estimation of Split Renal Function Using the Two Radiopharmaceuticals:Tc-99m DTPA & Tc-99m DMSA in Kidney Patients
Conditions
Brief summary
To evaluate split renal function using Tc-99m DTPA versus Tc-99m DMSA.
Detailed description
Split renal function (SPR) is a determination of the relative contribution of each of the two kidneys . It gives a useful information in several conditions such as evaluating unilateral renal disorders, assessing individual kidney function before and after intervention, and before live donor nephrectomy. Different radiopharmaceuticals such as technetium-99m dimercaptosuccinic acid (99mTc-DMSA), technetium-99m diethylenetriaminepentaaceticacid (99mTc-DTPA), technetium-99m mercaptoacetyltriglycine (99mTc-MAG3), Iodine 131 orthoiodohippurate and more recently technetium-99 m ethylenedicysteine (99mTc-EC) were used, However, 99mTc-DMSA as a static renal agent is considered the most reliable method to measure relative renal function and the most appropriate tracer for renal cortical imaging . In some papers, it is emphasized that relative renal function calculated with 99mTc-DTPA is as reliable as 99mTc-DMSA . The investigators design the study to evaluate the difference in estimation of split renal function using the available two radiopharmaceuticals: Tc-99m DTPA and Tc-99m DMSA.
Interventions
OTHERrenal scintigraphy
99mTc-DTPA Scintigraphy Five mci of 99mTc-DTPA will be injected by IV route together with diuretic. Dose will be adjusted according to the age and weight of the patients. A total of 20 min dynamic imaging followed by calculation of GFR and SRF according to the built-in processing protocol Gate's method. 99mTc-DMSA scintigraphy Five mci of 99mTc- DMSA will be injected by IV route with adjustment according to age and weight. Static images will be acquired in the posterior, anterior, andposterior oblique projections for 60 s each.
Sponsors
Assiut University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Months to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Kidney patients of wide age ranges. 2. Patients with renal disorders who referred for DMSA and DTPA split renal function. 3. Patients able to sleep in a fixed position for 20 minutes.
Exclusion criteria
1. Children unable to sit calm without movement during imaging. 2. Severely ill patients. 3. Patients with allergy to one or more of material method.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Split renal function using 99mTc-DTPA versus 99mTc-DMSA in kidney patients of wide age ranges. | one year | To emphasize that split renal function calculated with Tc-99m DTPA is as reliable as Tc-99m DMSA |
Contacts
Primary ContactMarwa F Abd El Hay
Backup ContactWaleed A Diab, MD
Outcome results
None listed