Hepatic Surgery
Conditions
Keywords
liver surgery, hepatic resection, inflammation, organ dysfunction, blood loss, IFABP
Brief summary
Monitoring of inflammatory substances (such as interleukins, CRP, albumine), and markers of organ dysfunction (such as creatinine, proenkephaline, amylase, troponine, IFABP and lactate) during elective liver resection. The study also includes monitoring of hemodynamic parameters, blood loss and postoperative complications. Results are to be used för power calculation for future trials.
Detailed description
During hepatic surgery, blood and urine samples will be obtained at 3 times during surgery, at 3 h after resection of liver, at 24 h after resection of liver and at post operative day 2, and subsequntly analyzed for the above mentioned substances. Routine labs will be monitored until patient is discharged from hospital. During surgery, hemodynamic parameters will be monitored by Picco calculations. Urine output and blood loss will be registred.
Interventions
PROCEDUREelective surgery, according to deprtement routine
none, descriptive study
Sponsors
Sahlgrenska University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
ASA I-III Patient has given informed consent to participate in study.
Exclusion criteria
preoperative kidney failure (E-GFR \>30), current infection treatment with corticosteroids coagulopathy surgical or anatomical conditions that makes patient unsuitable for participation (for example reoperation, need of vascular bypass, single tumor)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ischemic Intestinal Damage | from day of surgery until 24-48 hours postoperatively | rise in IFABP in nanograms/ml, |
| Kidney injury | from day of surgery and approximately 1 week onwards | as described by KDIGO (Kidney Disease Improving Global Outcomes) criteria |
| Intestinal Bacterial Transloction | from day of surgery until 24-48 hours postoperatively | Rise in D-lactate in micromol/ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Description of Inflammatory Response | from day of surgery and approximately 1 week onwards | Changes in MCP-1, SDF-1, IL-1beta, TNF-alfa, IL-6, IL-8, IL-10 and HMBG-1, in blood samples obtained during and after heptaic surgery |
Other
| Measure | Time frame | Description |
|---|---|---|
| blood loss | from day of surgery and approximately 1 week onwards | need of transfusion |
Countries
Sweden
Outcome results
None listed