Cancer
Conditions
Keywords
ARCH
Brief summary
The purpose of this study is to see if patients with cancer have a certain amount of genetic mutations in their blood. If certain levels of mutations are found in specific genes, patients may have a condition known as ARCH. The prevalence of ARCH is higher in cancer patients who received prior chemotherapy or radiation. Studying ARCH from your blood samples may also help researchers predict which patients are more likely to be prone to heart disease. Patients who are about to start chemotherapy/radiation, and patients who have completed chemotherapy/radiation will be approached to measure the incidence of ARCH. 5-10mL blood samples will be collected before and after treatment, and if ARCH is detected in a laboratory analysis, another blood sample will be collected. Patients with ARCH will repeat the blood collection yearly, and also be referred to a cardiology clinic for follow up.
Detailed description
This is a non-randomized, single-centre, observational study assessing the incidence of ARCH in cancer survivors. Patients over the age of 60 who had or will receive chemotherapy and/or radiation therapy for solid or hematologic malignancies at the Princess Margaret Cancer Centre will be considered. Based on the time point of treatment, patients will either fall into a post or prior chemotherapy/radiation cohort. Peripheral blood will be taken and will be sequenced for ARCH DNA mutations. Patients who have ARCH-related mutations at a variable allele frequency (VAF) of at least 0.5% we will repeat the genetic sequencing yearly to assess changes in mutational spectrum and VAF over time.
Interventions
OTHERMonitoring of ARCH variants
Blood samples will be tested for mutations, before patients are given Standard of Care chemotherapy/radiation or after given Standard of Care chemotherapy/radiation. Another testing is done after 3 months and after 1 year if positive for ARCH.
Sponsors
University Health Network, Toronto
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Inclusion criteria
* Age ≥ 60 * Completed chemotherapy and/or radiation therapy and are being followed at Princess Margaret Cancer Centre i) Patient must be in remission for \> 3 months after completing chemotherapy or radiation ii) Predicted 5 year survival of \>75% iii) Peripheral blood counts must have returned to normal as defined by: 1. Platelets ≥ 100 x 109/L 2. PMN ≥ 1 x 109/L Or * Prior to chemotherapy and/or radiation therapy at the Princess Margaret Cancer Centre. * All histologically/cytologically proven tumour types (solid tumours and hematologic malignancies) will be eligible. * Received or will receive regimens of chemotherapy or radiation with doses expected to produce transient myelosuppression (PMN\<0.5x109/L) in at least 80% of treated patients (The identification and definition of appropriate myelosuppressive chemotherapy and radiation regimens will be at the discretion of the treating physician and will vary among disease sites). * Patients must have the ability to understand the requirements of the study and provide written informed consent, which includes authorization for release of protected health information * Patient must be willing to provide a peripheral blood sample.
Exclusion criteria
* Any other condition that would, in the Investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns or compliance with clinical study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Referral to cardiology clinic | 6-12 months |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of ARCH stratified by tumor type. | 6-12 months |
Other
| Measure | Time frame |
|---|---|
| The spectrum of mutations stratified by tumor type. | 6-12 months |
| The number of patients referred to the ARCH clinic | 6-12 months |
| The change in VAF over time post chemotherapy/radiation | 6-12 months |
| The change in VAF pre and post chemotherapy/radiation | 6-12 months |
Countries
Canada
Outcome results
None listed