Uterine Pain
Conditions
Keywords
cesarean section, uterine contraction pain, propacetamol
Brief summary
To evaluate that perioperative regular usage of propacetamol to reduce post cesarean section uterine contraction pain and opioid consumption
Detailed description
The most common method of pain control after cesarean section is intravenous patient-control analgesia (IVPCA) with morphine. Multimodal analgesia could improve the quality of perioperative pain control and reduceside effects of opioids. Previous researches marked that perioperative pain after cesarean section includes somatic wound pain and visceral uterine contraction pain. According to Academy of Breastfeeding Medicine, propacetamol is a safe pain-killer for an expectant mother and almost free from breast milk after intravenous injection. This study is a prospective double-blind randomized-controlled trial to evaluate that propacetamol could reduce visceral uterine contraction pain after cesarean section. Post cesarean section women will divide into three groups: 1. pain control with IVPCA for 2 days 2. pain control with IVPCA and propacetamol 1g every 6 hours for 2 days 3. pain control with IVPCA and propacetamol 2g every 6 hours for 2 days
Interventions
DRUGPropacetamol 1g
pain control with IVPCA and propacetamol 1g every 6 hours for 2 days
DRUGPropacetamol 2g
pain control with IVPCA and propacetamol 2g every 6 hours for 2 days
DRUGIVPCA
pain control with IVPCA
Sponsors
Mackay Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnancy more than 36 weeks which is expected to receive Caesarean section * Post Caesarean section woman, age greater than or equal to 20 years old * ASA physical status class 1 or 2
Exclusion criteria
* ASA physical status class 3 or above * Less than 20 years old * Past caesarean section for longitudinal wounds * Undergone major abdominal surgery * Chronic pain * Allergic to morphine or Propacetamol * Liver dysfunction * Treatment with anticoagulant * Emergency operation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of pain assessed by NRS | Every 8 hours from post-anesthesia care unit to 2 days after the cesarean section | Change of pain assessed by Numerical Rating Scale: respondent selects a whole number (0-10 integers) that best reflects the intensity of the pain |
| Incidence of treatment-relate adverse events | Two days after the cesarean section | the complications or side effects during intervention, such as nausea/vomiting, skin itching, GI discomfort, urinary retention, and respiratory depression |
| Opioid consumption | Two days after the cesarean section | Comparison with the placebo group, the requirement of opoid |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Satisfaction assessed by the NRS | Two days after the cesarean section | Participants' satisfaction about post-operative pain management assessed by Numerical Rating Scale: respondent selects a whole number (0-10 integers , dissatisfied -\> satisfied) that best reflects the satisfaction. |
Countries
Taiwan
Outcome results
None listed