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Xylitol Chewable Tablets Versus Xylitol Chewing Gum in Geriatric Bedridden Patients

Effect of Dissolving Xylitol Chewable Tablets Versus Xylitol Chewing Gum on Salivary pH and Bacterial Count in Geriatric Bedridden Patients : Randomized Clinical Trial

Status
UNKNOWN
Phases
Early Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03877705
Enrollment
98
Registered
2019-03-18
Start date
2019-09-01
Completion date
2021-01-01
Last updated
2019-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Plaque, Saliva Altered

Keywords

Dental Plaque , salivary pH

Brief summary

This study will be conducted to evaluate the effectiveness of using dissolving Xylitol chewable tablets versus xylitol chewing gum with bedridden geriatric patients in increasing salivary pH and decreasing bacterial count in both saliva and interdental plaque.

Detailed description

This study will be conducted to evaluate the value of using dissolving Xylitol chewable tablets versus xylitol chewing gum with bedridden geriatric patients ,as an alternative to tooth brushing and mouth rinsing, in increasing salivary pH and decreasing bacterial count in both saliva and interdental plaque.plaque and salivary sampling will be taken in certain time ,at baseline T0, then after 5minutes T1, then at 15 days T3. Salivary pH will be measured by using pH meter and streptococcus mutans bacterial count will be calculated through culture in mitis salivarius bacitracin

Interventions

DRUGListerine ready tabs

Technically, it's a rectangular-shaped, bilayer-compressed tablet that once chewed, creates just enough liquid to swish around your mouth to get a whole-mouth clean feeling.As manufacture claimed the tablet is easy to use just in three simple steps: chew (to activate), swish (to clean), then swallow as unlike mouthwashes which may contain alcohol and other ingredients not intended for ingestion, Listerine Ready Tabs are alcohol-free and safe to swallow which is highly suitable for bedridden patients.

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)

Masking description

The operator will be blinded to material and assessors will be blinded to the material assignment.

Intervention model description

Geriatric bedridden patients

Eligibility

Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

1. Age range above 65 years old 2. Bedridden patients 3. Males or females 4. Concious patients 5. Co-operative patients approving to participate in the trial. 6. Subjects who signed informed consent

Exclusion criteria

1. Individuals had taken antibiotics during the last four weeks or anticipated doing so during the study 2. Subjects who wore removable prosthesis 3. Patients with systemic diseases that have any oral manifestations 4. History of Smoking 5. Allergy to any of chewing gum or tablets ingredients 6. Evidence of tempromandibular joint disorders 7. Presence of intraoral infections 8. Currently using any mouth rinse

Design outcomes

Primary

MeasureTime frameDescription
Salivary bacterial count15 daysStreptococcus mutans count in saliva

Secondary

MeasureTime frameDescription
Interdental plaque Bacterial count15 daysMesial and distal Interdental plaquns streptococcus mutans count

Other

MeasureTime frameDescription
Salivary pH15 daysDegree of acidity or alkalinity of salivary pH

Countries

Egypt

Contacts

Primary ContactManar MA Abd elmageed, Resident
dentalmena90@gmail.com+021287766120
Backup ContactDepartment Of Conservative dentistry, Department
operative@dentistry.cu.edu.eg+0201068685923

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026