Oral Cancer
Conditions
Brief summary
Control of cell death is frequently disrupted in cancer resulting in overgrowth of tumour cells. Caspase-8 is a key enzyme involved in controlling cell death. This study examines the importance of caspase-8 in oral cancer.
Detailed description
Control of cell death is frequently disrupted in cancer resulting in overgrowth of tumour cells. The caspase family of enzymes are the key performers of controlled cell death and caspase-8 is frequently mutated in oral cancer. This study will perform DNA sequencing to determine if the gene is wild-type (not mutated). The abundance of inactive (uncleaved) and active (cleaved) caspase-8 will be determined. The levels of the proteins that caspase-8 interacts with (including caspase-3) will be determined. Results will be correlated with tumour stage, patient outcome and the presence of immune cells and other microscopic features. This will improve the understanding of the importance of caspase-8 in oral cancer.
Interventions
There is no intervention. This is a retrospective study analysing archived tumour samples.
Sponsors
Guy's and St Thomas' NHS Foundation Trust
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Oral cancer * Sufficient follow up data
Exclusion criteria
* Patient has indicated that they do not wish their tissue to be used for research. * . The quantity or quality of tissue is too little or poor to provide adequate material without significant reserve. * The material contains bone.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Caspase-8 activity in oral cancer and its impact on disease progression | Up to 3 years | Molecular analysis of caspase-8 activity will be undertaken and correlated with tumour features and outcome. |
Countries
United Kingdom
Contacts
Primary ContactRobert Kennedy, BSc PhD BDS
Outcome results
None listed