Normal Pressure Hydrocephalus
Conditions
Keywords
lower urinary tract dysfunction, urinary incontinence, normal pressure hydrocephalus, overactive bladder
Brief summary
Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. Urinary symptoms in normal pressure hydrocephalus are mainly represented by overactive bladder, which is a significant burden for the concerned patients. A harmonization of neuro-urological practices in the pre-therapeutic evaluation of patients suffering from normal pressure hydrocephalus is necessary. The investigators conducted a bicentric prospective study aiming to evaluate the effect of depletive lumbar puncture on urinary symptoms in iNPH. The secondary objective was to evaluate, in the same participants previously diagnosed, the effect of cerebrospinal fluid shunt surgery on urinary symptoms.
Detailed description
Prospective study interventional but non invasive Bicentric in two universitarian hospitals in France On a cohort of patients presenting at least two out of three symptoms of the classic triad (urinary symptoms, cognitive symptoms and gait disturbance) and enlargement of ventricles non explained by cortical atrophy. Participants are offered, as routine care, a diagnostic evaluation of the effect of depletive lumbar puncture on these triad symptoms (this exam is part of routine care). Before the planned lumbar puncture, the participants are requested to participate to the study, with written consent and information given. The participants are requested to fill in a USP (urinary symptoms profile, validated international questionnaire) questionnaire and a micturition calendar. The same urinary evaluation is made 5 days after lumbar puncture. Gait and cognition are evaluated as in routine practice. Of the participants initially evaluated, some will be proposed shunt surgery (routine care). These participants will be proposed to fill in the same questionnaire and micturition calendar around 3 months after shunt surgery (post operative evaluation).
Interventions
DIAGNOSTIC_TESTUrinary symptoms profile questionnaire
Validated questionnaire (international) with validated french translation, before and after lumbar puncture, and after surgery if surgery is realized
DIAGNOSTIC_TESTMicturition calendar
Micturition calendar on 2 consecutive days, before and after lumbar puncture, and after surgery if surgery is realized
Sponsors
EssaiClinique_PL-HPN
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Evaluation of urinary symptoms before and after depletive lumbar puncture and after shunt surgery
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* 2/3 symptoms triad : gait disturbance + cognitive disturbance + urinary symptoms * Ventricular enlargement non explained by cortical atrophy
Exclusion criteria
* analphabetism or not french speaking * Cognitive disability making understanding of study impossible (as informed consent)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of depletive lumbar puncture on overactive bladder symptoms 1 | 5 days after lumbar puncture | evaluation on USP questionnaire, subsection HAV \[0-21\] |
| Effect of depletive lumbar puncture on overactive bladder symptoms 2 | 5 days after lumbar puncture | evaluation on micturition calendar on 2 days \[number of mictions/day\] |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of shunt surgery on overactive bladder symptoms 1 | 3 to 4 months after surgery | evaluation on micturition calendar on 2 days \[number of mictions/day\] |
| Effect of shunt surgery on overactive bladder symptoms 2 | 3 to 4 months after surgery | evaluation on USP questionnaire, subsection HAV \[0-21\] |
Countries
France
Contacts
Primary ContactJean Alexandre LONG, MD PHD
Backup ContactElsa Bey, Resident
Outcome results
None listed