Leukemia
Conditions
Keywords
leukemia, chemotherapy, respiratory training
Brief summary
Forty male leukemic patients receiving chemotherapy were selected from National Cancer Institute, They were randomly assigned into two groups. Group (A) included 30 patients who were trained by Inspiratory muscle trainer for 4 weeks ;5 sessions/week and Group (B) included 10 patients as a control group. The following measures were taken before and after the study period : Maximum voluntary ventilation(MVV) , 2 min walk test, FACT-G questionnaire
Detailed description
Forty male leukemic patients receiving chemotherapy for at least one cycle and their mean ages 37.1 ± 4.89 years.The patients were selected from National Cancer Institute, Cairo ( inpatient ward). The study lasted from March 2018 to June 2018. Patients were randomly assigned into two groups.Group A (30 patients) who received inspiratory muscles training for 4 successive weeks, 5 sessions/week; and Group B (10 patients) acted as a control group on chemotherapy only. Data obtained from both groups regarding (MVV), 2 min walk test and Quality of life questionnaire (FACT-G) were statistically analyzed and compared
Interventions
OTHERrespiratory training
Respiratory training was done by using threshold inspiratory muscle trainer(Respironics, New Jersey , USA, No.8373-0730)
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
30 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* male patient with age ranges from 30-50 years * All patients were leukemic receiving chemotherapy for at least one cycle as a treatment of malignant tumor * All patients were hemodynamically stable * All patients were ambulant
Exclusion criteria
* lung cancer * History of any pulmonary disease. * Metastasis of lungs, ribs, mediastinal structure * Pulmonary pathology(e.g acute respiratory distress syndrome or exacerbation of chronic obstructive pulmonary disease) * ruptured ear drum or any other condition of the ear * High peak airway pressure (barotraumas) * patients with marked elevated left ventricular end diastolic volume and pressure * patients with worsening heart failure signs and symptoms
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximum voluntary ventilation | change from baseline maximum voluntary ventilation at 4 weeks | It was performed by breathing deeply and rapidly for 10 to 15 seconds using spirometer |
| 2 min walk test | change from baseline 2 min walk test at 4 weeks | Each patient was asked to cover as much ground as possible over 2 minutes |
| FACT-G questionnaire | change from baseline FACT-G questionnaire at 4 weeks | 27 questions with four domains assessing physical well being,social well being, emotional well being and functional wellbeing |
Countries
Egypt
Outcome results
None listed