Detection of Bone Marrow Metastases With Magnetic Resonance Imaging

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03876392

Enrollment

Registered

2019-03-15

Start date

2019-05-10

Completion date

2022-12-31

Last updated

2021-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Marrow Metastases, Magnetic Resonance Imaging

Brief summary

The goal of this clinical trial is to study the value and feasibility of magnetic resonance imaging in detection of bone marrow metastases

Detailed description

The patient was diagnosed as bone metastasis by pathology. CT showed no bone marrow biopsy site metastasis (anterior iliac spine or posterior iliac spine). After functional magnetic resonance examination, bone marrow biopsy was performed. Functional magnetic resonance imaging includes conventional SE sequence, T2W SPAIR, e-THRIVE,DWI,IVIM. With bone marrow biopsy as the gold standard, the sensitivity, specificity and coincidence rate of functional MRI in the diagnosis of bone marrow metastasis were evaluated.

Interventions

DIAGNOSTIC_TESTmagnetic resonance imaging

Compare bone marrow biopsy with magnetic resonance imaging to detect bone marrow metastases

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

1. Patients with malignant tumors (solid tumors or hematological malignancies) were definitely diagnosed by pathology or cytology. 2. patients with bone metastases confirmed by more than two imaging examinations. 3. Age 18-75. 4. ECOG score: 0-2. 5. The expected survival time is more than 3 months. 6. Sign the informed consent.

Exclusion criteria

1. Imaging findings suggest that bone metastases are present at the bone marrow puncture site. 2. The patient refused bone marrow puncture. 3. Puncture site with infection. 4. Severe coagulation dysfunction. 5. There are implanted instruments in the body, so magnetic resonance imaging can not be performed.

Design outcomes

Primary

Measure	Time frame	Description
sensitivity	through study completion, an average of 1 year	With bone marrow biopsy as the gold standard, the sensitivity of functional MRI in the diagnosis of bone marrow metastasis
specificity	through study completion, an average of 1 year	With bone marrow biopsy as the gold standard, the specificity of functional MRI in the diagnosis of bone marrow metastasis

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026