HCC, Quality of Life
Conditions
Keywords
HCC, HCC in elderly, recurrent HCC, Liver resection, Quality of Life, intervention radiology, RF, TACE
Brief summary
Aim of this study is to evaluate whether treating HCC recurrences in resected elderly patients is advantageous or not.
Detailed description
Introduction- Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. It usually develops in cirrhotic liver with high recurrence rates. More than 2/3 of patients are elderly, often excluded from surgery and follow-up protocols. Aim of this study is to evaluate whether treating HCC recurrences in resected elderly patients is advantageous or not. Materials and methods- 126 patients, aged between 65 and 90 years, submitted to liver resection for HCC were enrolled. They were divided into three classes. Class 1 included patients submitted to major resections, Class 2 to minor resections and Class 3 to minor resections associated with thermoablation. All of them were clinically and radiologically followed up. Patients who developed recurrences (Group A) were referred to further treatments (surgery, interventional radiology or pharmacological therapy). Mortality, disease-free survival (DFS), overall survival (OS) and quality of life (QoL) were evaluated and compared with non-recurrent patients (Group B). Used interventional radiology means were Radiofrequency ablation (RF), microwaves ablation (MWA) or transcatheter arterial chemoembolization (TACE).
Interventions
PROCEDUREliver resection
resection of one or more HCC nodules within the liver
PROCEDUREThermic ablation
ablation of HCC nodule through a percutaneous needle, by using radiofrequency or microwaves
PROCEDURETranscatheter arterial chemoembolization
embolization of HCC nodule via drug-eluted microbeads.
Sponsors
Azienda Policlinico Umberto I
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* HCC patient * eligible for surgery
Exclusion criteria
* non eligible for surgery at first HCC diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival | follow up time 1-16 years | survival in months |
| Disease free survival | follow up time 1-16 years | survival without recurrences in months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Instrumental Activity of Daily living | follow up time 1-16 years | assess the ability to use common instruments evaluated in dimensionless scale 1-8 |
| Blood Haemoglobin | follow up time 1-16 years | evaluation of mean haemoglobin levels in g/dl |
| Karnofsky performance scale | follow up time 1-16 years | evaluation of performance status in dimensionless scale 0 - 100 |
| Geriatric Depression Scale | follow up time 1-16 years | evaluation of depression in patients in dimensionless scale 0 - 15 |
| serum Albumin | follow up time 1-16 years | evaluation of mean albumin levels in g/dl |
| Activity of Daily living | follow up time 1-16 years | assess the ability to manage common routine activities evaluated in dimensionless scale 1-6 |
Countries
Italy
Outcome results
None listed