Neurocysticercosis, Taeniosis
Conditions
Keywords
Neurocysticercosis
Brief summary
This study aims to determine the prevalence of taeniosis and (neuro)cysticercosis in two districts in the southern (Gwembe) and eastern province (Chipata) of Zambia.
Detailed description
The true prevalence of Neurocyticercosis in Zambia is not well known. Only one study which was a pilot study done in Katete district of eastern province demonstrated the prevalence of NCC among people with epilepsy. There is need to provide an accurate estimate of the prevalence of NCC among people with cysticercosis in Zambia as well as understand the clinical manifestations of the disease in humans. Data on the full range of clinical characteristics of NCC is essential to accurately estimate the burden of the disease in the community. The epidemiology work package within the human health sector will create awareness of the size of the problem by delivering scientifically generated prevalence data on TSCT and NCC in various population groups (adults, children, and those living with epilepsy) in two provinces of Zambia. This will form an essential prerequisite for the development of public health policy guidelines for the control/elimination of TSCT/NCC in the country. Further, environmental factors that could play a role in the transmission and maintenance of T. solium eggs will be studied. This will provide essential data in understanding the epidemiology of the parasite in endemic regions.
Interventions
None listed
Sponsors
Technical University of Munich
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
10 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Willing and able to participate in all aspects of the study, including providing blood and stool samples, participating in a questionnaire survey and group discussions, and taking oral anthelmintic tablets * Willing and able to provide informed consent (signature or thumbprint with impartial witness; assent for minors with parental consent). * Living in, attending school in, or regularly visiting the bore holes present in, the study communities. * Aged 10 years or older
Exclusion criteria
* Unwilling or unable to participate in some or all aspects of the study, including providing blood and stool samples, participating in a questionnaire survey and group discussions, or taking oral anthelmintic tablets. * Unwilling or unable to provide written (signature or thumbprint with impartial witness) informed consent (or assent for minors). * Living outside of, and not regularly visiting, or attending school in, the study communities. * Children aged less than 10 years. * Seriously ill individuals (people unable to engage in the normal activities of daily living without assistance because of their illnesses).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of T. solium cysticercosis | Assessment through blood sampling at baseline | Prevalence of human T. solium cysticercosis |
| Prevalence of neurocysticercosis | Assessment at CT scanning at baseline | Prevalence of human neurocysticercosis among people with positive serology for T. solium cysticercosis |
| Prevalence of taeniosis | Assessment through stool sampling at baseline | Prevalence of human T. solium taeniosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of intestinal helminth infection | Assessment through stool sampling at baseline | Prevalence of intestinal helminth infection |
Countries
Zambia
Outcome results
None listed