Atrial Function
Conditions
Brief summary
Transversal retrospective and unicentric study. The investigators sought to determine the normal values for two-dimensional myocardial left atrial strain for the cardiology ultrasound system available in their centre (Philips EPIQ ultrasound machine and 10.8.5 QLAB cardiac analysis software). Studies performed in their department which meet the criteria for an adequate strain analysis will be retrospectively reviewed.
Interventions
DIAGNOSTIC_TESTtwo-dimensional speckle tracking
Analysis of myocardial left atrial strain using two-dimensional speckle tracking echocardiography.
Sponsors
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* No history of cardiopathy / pneumopathy. * No history of hypertension or mellitus diabetes.
Exclusion criteria
* Pregnancy. * Athletes. * Body mass index \< 16 or =\> 30 kg/m2. * Previous treatment with cardiotoxic chemotherapy. * Dilated left ventricle (telediastolic diameter index \> 30 mm/m2). * Interventricular septal thickness =\> 12 mm. * Dilated left atria (volume =\> 31 ml/m2). * Systolic pulmonary pressure =\> 35 mmHg. * Moderate or severe valvulopathy. * Incomplete or suboptimal left atrial visualization. * Frame rate \< 50 fps.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Global peak reservoir strain. | Through study completion, an average of 4 months. | Percentage of peak reservoir strain for 4-, 2- and 3-chambers will be combined to report percentage of global peak reservoir strain. |
| Global pump strain. | Through study completion, an average of 4 months. | Percentage of pump reservoir strain for 4-, 2- and 3-chambers will be combined to report percentage of global pump strain. |
| Global conductance strain. | Through study completion, an average of 4 months. | Measured as the difference between global reservoir strain and gobal pump strain. |
| Global reservoir strain rate. | Through study completion, an average of 4 months. | Reservoir strain rate for 4-, 2- and 3-chambers will be combined to report global reservoir strain rate. |
| Global conductance strain rate. | Through study completion, an average of 4 months. | Conductance strain rate for 4-, 2- and 3-chambers will be combined to report global conductance strain rate. |
| Global pump strain rate. | Through study completion, an average of 4 months. | Pump strain rate for 4-, 2- and 3-chambers will be combined to report global pump strain rate. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Left ventricular telediastolic volume | Through study completion, an average of 4 months. | Measured by Simpson's method |
| Left ventricular dimensions | Through study completion, an average of 4 months. | Assessed by the following parameters: telediastolic diameter, interventricular septal thickness, posterior wall thickness (in mm) |
| Age in years | Through study completion, an average of 4 months. | — |
| E/e' ratio | Through study completion, an average of 4 months. | Tissue doppler derived parameter. |
| E/A ratio | Through study completion, an average of 4 months. | Transmitral flow profile. |
| Sex | Through study completion, an average of 4 months. | male or female |
| Weight in kilograms | Through study completion, an average of 4 months. | — |
| Height in meters | Through study completion, an average of 4 months. | — |
| Left atrial volume | Through study completion, an average of 4 months. | Measured by biplanar volumetric method |
| Left ventricular ejection fraction | Through study completion, an average of 4 months. | Measured by biplanar Simpson's method |
Countries
Spain
Contacts
Primary ContactLidia Bos Real
Outcome results
None listed